Custom Peptides
Cayman Chemical 3hydroxy9 10DImethoxypTRo 10mg
A flavonoid; inhibits PDGF-BB-induced proliferation of, and DNA synthesis in, A-10 vascular smooth muscle cells (IC50s = 10 and 1 µM, respectively)
Cayman Chemical ParecoxIbsodIum salt 10mg
A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys; a CB1 agonist (EC50 = 2.4 µM in HEK293 cells); reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg)
Cayman Chemical NIguldIpInhydrochlorIde 10mg
A dihydropyridine that acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM); less potently blocks L- and T-type Ca2+ channels (IC50s = 0.4 and 0.9 µM, respectively)
Cayman Chemical TG11-77hydrochlorIde 10mg
An EP2 receptor antagonist (KB = 9.7 nM); selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively); inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors at 0.3 and 1 μM
Cayman Chemical MethylophIopogonon B 10mg
An isoflavone; increases Rho activity in NHEMs at 1 µM; inhibits LPS-induced NO production in BV-2 microglia (IC50 = 7.8 µM); reduces hydrogen peroxide-induced production of ROS, apoptosis, and decreases in SOD activity in HUVECs at 40 and 50 µM; cytotoxic to SMMC-7721 and HeLa cancer cells (IC50s = 34.6 and 6 UG/ml, respectively)
Cayman Chemical GnIrelIxacetate 10mg
A GNRHR antagonist (IC50 = 3.6 nM; pA2 = 9.3); induces a concentration-dependent increase in histamine release from rat peritoneal mast cells in vitro (EC50 = 11 μg/ml); decreases plasma testosterone in intact male rats for the first 7 days post-administration (2 mg/kg, s.c.); decreases the surface area of endometriotic lesions and serum progesterone levels in female baboons (125 μg per day for 30 days)
Cayman Chemical DIroxImel Fumarate 10mg
A prodrug form of monomethyl fumarate; undergoes esterase cleavage in the gut to release monomethyl fumarate
Cayman Chemical 20 R-GInsenosIde Rh2 10mg
A steroid glycoside with diverse biological activities; inhibits the replication of MHV-68 (IC50 = 2.77 μM) and the lytic replication of human gammaherpes virus in BC3 cells; reduces levels of NO, PGE2, ROS, and pro-MMP-9 in LPS-stimulated RAW 264.7 cells; reduces ROS production and MMP-9 and MMP-2 activity in HaCat human keratinocytes; induces tumor cell apoptosis and reduces tumor growth in an H22 hepatocellular carcinoma mouse xenograft model at 4 mg/kg
Cayman Chemical SynthetIc PrunIn 10mg
A flavonoid glycoside with diverse biological activities; inhibits NA activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 3 and 4.53 µM, respectively); scavenges DPPH radicals in a cell-free assay at 2 µM; inhibits the activity of PTP1B (IC50 = 5.5 µM for the human enzyme); increases insulin-induced glucose uptake in insulin-resistant HepG2 cells; inhibits proliferation of, and induces apoptosis in, HL-60 cells
Cayman Chemical 5-HenIcosylresorcInol 10mg
An alkylresorcinol; reduces hydrogen peroxide-induced DNA damage in HT-29 cells at 100 µmol/L; inhibits migration and invasion, reduces the number of LC3 puncta, a marker of autophagy, and decreases survival in HepG2 cells at 160 UG/ml when used in combination with 5-nonadecanoylresorcinol
Cayman Chemical 1PalmItoyl2Oleoylracglyc 10mg
A diacylglycerol; has been found in crude sunflower lecithin; levels increase in RINm5F rat insulinoma cells treated with oleate, elaidate, or trans-vaccenate
Cayman Chemical BrIvnIb AlnInate 10mg
A prodrug form of brivanib; reduces hepatic angiogenesis and VEGF, TGF-β1, CD31, and phosphorylated VEGFR2 and FGFR levels in a bile duct-ligated rat model of cirrhosis at 3 mg/kg per day; reduces tumor growth in an L2987 non-small cell lung cancer mouse xenograft model, exhibiting 97% tumor growth inhibition at 107 mg/kg
Cayman Chemical ADL5859hydrochlorIde 10mg
A δ-opioid receptor agonist (Ki = 0.84 nM); selective for δ-opioid receptors over μ-opioid and κ-opioid receptors at 10 μM; completely reverses CFA-induced mechanical hyperalgesia in rats at 3 mg/kg; decreases immobility time in the forced swim test in rats
Cayman Chemical 2 3DImethylethcathInonhyd 10mg
A disubstituted analog of ethcathinone; intended for forensic and research purposes
Chem-Impex International, Inc. FMOC GLY THR PSI MEME PRO OH1G
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