Custom Peptides
Cayman Chemical NodInItIb-1 10mg
Selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability
Cayman Chemical MIsoprostolfree acId 10mg
Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 UG/kg),{1754} inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; Item No. 10006317) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}
Cayman Chemical 2-MethoxyestradIol 10mg
A natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol; has anticancer agent activity as an angiogenesis inhibitor via the HIF-1α pathway; levels are significantly lower in women with severe pre-eclampsia
Cayman Chemical LY266097hydrochlorIde 10mg
A 5-HT2B receptor antagonist (Ki = 0.5 nM); selective for 5-HT2B over 5-HT2A and 5-HT2C receptors (Kis = 19.5 and 24.55 nM, respectively); reduces L5/L6 spinal nerve ligation-induced hind paw tactile allodynia in a rat model of neuropathic pain at an intrathecal dose of 100 nmol; reduces hyperlocomotion induced by cocaine in rats at 0.63 mg/kg
Cayman Chemical dIacetoxy ScIrpenol 10mg
A trichothecene mycotoxin; is toxic to pigs (LD50 = 0.38 mg/kg, i.v.); is lethal to brine shrimp (LC50 = 0.39 UG/ml); suppresses phagocytosis by, and superoxide production in, isolated microphages in an S. cerevisiae model of phagocytosis at 1 UG/ml; is toxic to barley, wheat, and sorghum seedlings (LD50s = 1.26, 3.98, and 10 mg/L, respectively); has been found as a contaminant in grasses intended to be used as animal feed
Cayman Chemical NKH477hydrochlorIde 10mg
A water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously; stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms; relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM
Cayman Chemical DaunorubIcInhydrochlorIde 10mg
An antitumor antibiotic that induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia cells at 0.2-1 μM; triggers a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK
Cayman Chemical ngIotensIn IIhumnaceta 10mg
A peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke
Cayman Chemical Taurolthocholc ACD 3sulfa 10mg
A metabolite of taurolithocholic acid; has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis
Cayman Chemical 4-amIno-1 8-NaphthalImIde 10mg
An inhibitor of PARP (IC50 = 180 nM); blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation
Cayman Chemical PPAdodIum salt 10mg
A non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors; produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats
Cayman Chemical Losartn CarboxylIc AcId 10mg
An AT1b receptor antagonist and active metabolite of losartan; an antagonist of AT1b (Kis = 0.67 nM in COS-7 cells expressing the human receptor); selective for AT1b over AT2 (Ki = >10,000 nM in COS-7 cells expressing the human receptor); reduces U-44619-induced aggregation of platelets in isolated human platelet-rich plasma at 50 µM; reduces MAP in water-deprived rats at 1 mg/kg
Cayman Chemical IvabradInhydrochlorIde 10mg
An HCN channel blocker; blocks If in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 μM, respectively); reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction at 10 mg/kg
Cayman Chemical MIldronatehydrate 10mg
A structural analog of γBB that inhibits γBB hydroxylase (IC50 = 62 µM) and carnitine acetyltransferase (Ki = 1.6 mM); has cardioprotective and neuroprotective effects; improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease
Cayman Chemical VarenIclIntartrate 10mg
An agonist of α7 and α4β2 nAChRs (EC50s = 18 and 2.3 µM, respectively)