Custom Peptides
Cayman Chemical PeImIsInhydrochlorIde 10mg
A steroidal alkaloid; inhibits rat lung AChE by 20.2% at 200 μM
Cayman Chemical EtIcloprIdehydrochlorIde 10mg
A D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively); selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, Histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as 5-HT1 and 5-HT2 receptors (IC50s = 6,200 and 830, respectively) in radioligand binding assays; binds α1-ARs (IC50 = 110 nM); inhibits 7-OH-DPAT-induced stereotyped behavior in rats at 10 μg/kg; inhibits inhibits ketamine- and cocaine-induced hypermotility in rats at 20 and 50 μg/kg, respectively
Cayman Chemical 25I-NBOHhydrochlorIde 10mg
A derivative of 2C-I that acts as a potent agonist for the human serotonin 5-HT2A receptor (Ki = 0.061 nM); intended for research and forensic applications
Cayman Chemical SchIsndrIn C 10mg
A lignan with diverse biological activities; decreases viability of U937 cells induces cell cycle arrest at the G1 phase; decreases hydrogen peroxide-induced cell death and production of ROS in C2C12 skeletal muscle cells from 5-20 μM; decreases levels of MMP-2, MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells; decreases lipoteichoic acid-induced production of NO, PGE2, TNF-α, IL-1β, and IL-6 in mouse primary microglia; decreases serum ALT and AST activity, increases hepatic mitochondrial and total GSH levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury
Cayman Chemical MethoxphenIdInhydrochLRId 10mg
An analog of diphenidine featuring a methoxy group at the two position of a phenyl group
Cayman Chemical Daclatsvr 10mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical sorentn 10mg
A flavonoid with diverse biological activities; induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells; reduces expression of COX-2, IL-6, 5-LO, and TNF-α in RAW 264.7 cells; reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice at 20 mg/kg; increases stomach levels of SOD and GSH and reduces ulcer area in a rat model of indomethacin-induced gastric ulcers
Cayman Chemical ElagolIxsodIum salt 10mg
An antagonist of GnRHR (Ki = 0.9 nM in a radioligand binding assay); selective for GnRHR over CYP3A4 (IC50 = 56 μM) as well as a panel of 100 receptors, ion channels, enzymes, and transporters (IC50s = >10 μM); inhibits GnRH-induced inositol phosphate production in RBL-1 cells expressing human GnRHR (IC50 = 1.5 nM); suppresses production of luteinizing hormone in castrated male cynomolgus macaques at 30 mg/kg
Cayman Chemical SphngosInd14 1 10mg
A bioactive sphingolipid; has been found in B. mori, P. clarkii, and A. aurita extracts; increases the germination rate of N. rileyi (EC50 = 0.0102 ng/ml); inhibits PKC in vitro (IC50 = 7.3 mol %); inhibits PMA-induced superoxide generation in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively)
Cayman Chemical DelphInIdIn3OrutInosIdec 10mg
A glycosylated anthocyanin with antioxidant activity; inhibits TBHP-induced loss of viability in isolated rat aortic SMCs, but not MH1C1 cells, at 100 µM; prevents TBHP-induced DNA damage, as well as inhibits TBHP-induced increases in MDA levels, in SMCs; displays a hydrogen peroxide-induced and pH-dependent chemiluminescence peak at pH 7
Cayman Chemical L-QuIsqualIc AcId 10mg
A natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as (GRIK4 (Ki = 6.43 nM)
Cayman Chemical BenIdIpInhydrochlorIde 10mg
An orally bioavailable inhibitor of L-, T-, and N-type calcium channels; IC50 = 2.7 nM in guinea pig ventricular cells; prevents oxidative stress in vitro and in neural stem cells; has antihypertensive effects; competitive antagonist at mineralocorticoid receptors
Cayman Chemical CID-5157334 10mg
A surrogate agonist of GPR27; induces recruitment of β-arrestin-2 in complementation assays using wild-type GPR27 or a GPR27V2 chimeric receptor (EC50s = 7.943 and 0.417 nM, respectively) but does not induce β-arrestin-1 recruitment in the same assay or activation of the Gq, Gs, or Gi signaling pathways in aequorin-GFP assays; selective for GPR27 over GPR85V2 and GPR173V2 chimeric receptors at 15 µM