Custom Peptides
Cayman Chemical NorsufentnIl 10mg
A metabolite of sufentanil, produced by oxidative N-dealkylation in the liver by CYP450 isoforms; intended for forensic applications
Cayman Chemical PregntrIol 10mg
A metabolite of 17α-hydroxyprogesterone; urinary levels are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia
Cayman Chemical Blonanserin 10mg
A mixed antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors (Kis = 0.14, 0.49, and 0.81 nM, respectively) that also binds to 5-HT6 (Ki = 11.7 nM); developed as a novel antipsychotic that displays 20- and 94-fold higher affinity for D2 receptors compared to haloperidol and risperidone, respectively
Cayman Chemical Desmethylen ParoxetInhydr 10mg
A major urinary metabolite of the selective serotonin reuptake inhibitor paroxetine; may be used as a control in LC/MS or GC/MS paroxetine testing applications
Cayman Chemical CRT0066101hydrochlorIde 10mg
A pan inhibitor PKD (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively); blocks cell proliferation, induces apoptosis, and reduces the viability of pancreatic cancer cells both in vitro and in vivo
Cayman Chemical C4 CeramIded18 14 0 10mg
A bioactive sphingolipid; inhibits IL-4 production by 16% in PMA-stimulated EL4 T cells at 10 μM; cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively); increases maturation and stability of F508del-CFTR proteins, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis
Cayman Chemical TIpIracIlhydrochlorIde 10mg
A thymidine phosphorylase inhibitor (IC50 = 35 nM); selective for thymidine phosphorylase over UPase, TK, OPRTase, and DPD (IC50s = > 1,000 µM for all); inhibits SARS-CoV-2 endoribonuclease nsp15 (IC50 = 7.5 µM); reduces the levels of SARS-CoV-2 spike glycoprotein in SARS-CoV-2-infected A549 cancer cells at 50 µM; prevents trifluorothymidine metabolism in human liver extracts at 1 µM; increases the plasma levels and potentiates the cytotoxicity of trifluorothymidine in an AZ-521 gastric carcinoma mouse xenograft model at an equimolar dose
Cayman Chemical DIhydromyrIcetIn 10mg
A flavanonol with diverse biological activities; scavenges DPPH radicals (IC50 = 0.235 μg/ml) and decreases AAPH-induced ROS generation in human erythrocytes (6 μg/ml); dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells; decreases tumor volume by 43.5% in a mouse xenograft model of HepG2 cells (500 mg/kg per day); binds to GABAA receptors in rat cortical membrane reparations (IC50 = 4.36 μM); dose-dependently reduces LORR in ethanol-intoxicated rats; improves cognitive deficits in a mouse model of Alzheimer's disease (2 mg/kg for three months)
Cayman Chemical SertralInhydrochlorIde 10mg
A selective serotonin reuptake inhibitor; inhibits monoamine uptake by SERT (IC50 = 70 nM); selective for SERT over the norepinephrine and dopamine transporters (IC50s = 520 and 720 nM, respectively); reduces immobility in the forced swim test in mice at 3.2-56 mg/kg, s.c.; prevents acid sphingomyelinase activation and subsequent ceramide release induced by pp-VSV-SARS-CoV-2 infection in Vero cells at 5 µM
Cayman Chemical IsorhamntIn 10mg
A natural flavonol aglycone that has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM); competitively inhibits MATE1, Ki = 0.32 µM); potentiates the neurological actions of nerve growth factor, diminishes the cardiotoxic impact of doxorubicin, and can have beneficial anti-cancer effects
Cayman Chemical PhIlnthotoxIn 74hydrochLR 10mg
A subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM); inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM
Cayman Chemical AzumolensodIum salt 10mg
A muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum; inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes
Cayman Chemical Carbaprostacycln mthyl St 10mg
A more lipid soluble form of carbaprostacyclin; may more readily enter cells to activate PPARδ; may be more amenable for dietary formulations
Cayman Chemical 4ChLRomethamphetamInhydr 10mg
A halogenated analog of methamphetamine; converted to 4-chloroamphetamine in vivo