Custom Peptides
Cayman Chemical DermorphInacetate 10mg
An opioid peptide; binds to μ-opioid receptors (Ki = 0.54 nM) and is selective for μ- over δ-opioid receptors in radioligand binding assays (Ki = 929 nM); inhibits noxious stimuli-induced neuronal firing in the nucleus lateralis anterior and ventrobasal complex in rats at 1.9 µmol/kg; inhibits the electrical stimulation-induced C fiber response in rat dorsal horn nociceptive neurons; delays gastric emptying, inhibits gastric acid secretion, and slows colonic motility in pylorus-ligated rats from 10-120 pmol/animal
Cayman Chemical IndIMIII thIosemIcarbazon 10mg
An anticancer agent; cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11 µM, and 8.95 µM, respectively); decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells; reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model at 2.5 µmol/kg; liposomes containing it induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model
Cayman Chemical CTOPtrIfluoroacetate salt 10mg
An antagonist of the μ-opioid receptor (IC50 = 2.8 nM); selective for μ-opioid receptors over δ-opioid receptors (IC50 = 13,500 nM) and somatostatin receptors (IC50 = 24,000 nM); inhibits the antinociceptive effect of morphine in the tail flick test in mice (ED50 = 0.018 nmol) and reverses morphine-induced increases in locomotor activity (ED50 = 0.02 nmol); induces withdrawal symptoms in a mouse model of chronic morphine dependence
Cayman Chemical Progesteron 3PEG11bIotIn 10mg
An affinity probe with a hydrophilic spacer that allows progesterone to be detected or immobilized using the biotin ligand
Cayman Chemical PItofenonhydrochlorIde 10mg
An antispasmodic agent; an inhibitor of AChE (Kis = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively); inhibits acetylcholine-induced contractions of isolated guinea pig ileum at 2.5 μM
Cayman Chemical 1 2 3TrIundecnoyl GlycRol 10mg
A triacylglycerol; dietary administration prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats
Cayman Chemical 1Ohexadecyl2EIcosapentaen 10mg
Can be formed by incorporation of EPA into lyso-PAF C-16, as has been demonstrated using neutrophils from monkeys and humans fed a diet enriched in fish oils; serves as a substrate for PAF C-16 formation by the remodeling pathway.
Cayman Chemical N 2Fluorophenthyl5 2me 10mg
An inhibitor of HIF-1 signaling (IC50 = 0.32 μM in a cell-based HRE reporter assay under hypoxic conditions); inhibits hypoxia-induced increases in HIF-1α levels in MDA-MB-231, SKOV3, and HeLa cells in a concentration-dependent manner; inhibits hypoxia-induced VEGF expression and capillary-like tube formation in HUVECs; inhibits migration and invasion of MDA-MB-231 cells in wound healing and transwell assays under hypoxic conditions; reduces lung metastasis in an MDA-MB-231 mouse xenograft model at 15 and 30 mg/kg every other day
Cayman Chemical BeprIdIlhydrochlorIde 10mg
A dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle; recognized as a non-selective channel blocker
Cayman Chemical DalcetrapIb 10mg
An inhibitor of CETP; inhibits plasma CETP with an IC50 value of 9 µM; in rabbits given an atherogenic diet, increases HDL, decreases VLDL, and attenuates induced atherosclerosis; in humans, inhibits CETP activity and increases HDL levels but does not reduce the risk of recurrent cardiovascular events
Cayman Chemical 4EthylethcathInonhydrochl 10mg
A substituted cathinone with potential for abuse; intended for forensic applications
Cayman Chemical SaquInavIrmesylate 10mg
An HIV protease inhibitor (Kis = 0.12 and 50 = 2 nM); inhibits SARS-CoV-2 Mpro activity (IC50 = 9.92 µM)
Cayman Chemical ThIoetheramIde-PC 10mg
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of sPLA2.{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}
Cayman Chemical KIntensInhumntrIfluoro 10mg
A neurotensin ligand; binds to neurotensin receptors in HT-29 cells and mouse brain (Kis = 1,396 and 149.6 nM, respectively) but does not induce the accumulation of intracellular calcium in HT-29 cells (EC50 = >10,000 nM); induces histamine release in isolated rat peritoneal mast cells (EC50 = ~10 µM); induces vascular permeability in rats