Custom Peptides
Cayman Chemical 1S 4SNdSmethyl SRtralIn 10mg
A metabolite of sertraline; inhibits 5-HT and DA uptake in the rat corpus striatum (IC50s = 0.45 and 3.8 µM, respectively) and NE uptake in the rat hypothalamus (IC50 = 4.6 µM); does not increase extracellular levels of 5-HT or decrease extracellular levels of 5-HIAA in the rat striatum; does not increase cell firing in the rat dorsal raphe at 1,000 UG/kg, i.v.
Cayman Chemical Ctrus maxa peel Mernzn 10mg
A coumarin with diverse biological activities; cytotoxic to NSCLC-N6 and KB cancer cells (IC50s = 14.6 and 12.3 UG/ml, respectively); increases the latency to paw withdrawal in the hot plate test and reduces xylene-induced EAr edema in mice at 10 mg/kg; decreases carrageenan-induced paw edema in rats at 10 mg/kg
Cayman Chemical aPIperIdInobutIophenonhyd 10mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical AdrenorphInhumnmousera 10mg
An octapeptide agonist of μ-opioid receptors; selectively binds to μ-opioid receptors over κ- and δ-opioid receptors (Kis = 0.12, 0.248, and 2.65 nM, respectively); increases the latency to paw licking in the hot plate test in mice at 6.1 nmol/animal, i.c.v.; induces respiratory depression in mice and rabbits (ED50s = 6 and 71.1 nmol/animal, respectively)
Cayman Chemical L-Tryptophn-d5 10mg
An internal standard for the quantification of L-tryptophan by GC- or LC-MS
Cayman Chemical 5methoxy TryptamInhydroch 10mg
An analytical reference standard categorized as a tryptamine; intended for research and forensic applications
Cayman Chemical IACS-010759 10mg
An orally bioavailable inhibitor of mitochondrial complex I; inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I at 60 nM; reduces basal and spare respiratory capacities and increases glycolytic flux in primary CLL cells at 100 nM; induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose; induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model when administered at doses of 5 and 10 mg/kg
Cayman Chemical FluspIrIlen 10mg
A dopamine D2 and D3 receptor antagonist (Kis = 1.5 and 1.1 nM, respectively); selective for dopamine D2 and D3 receptors over dopamine D1, α1- and α2-adrenergic, H1 histamine, and σ1 receptors (Kis = 450, 102, >5,000, 540, and 150 nM, respectively), mAChRs (Ki = >5,000 nM), and 5-HT1A, 5-HT1B, 5-HT2C, and 5-HT3 receptors (Kis = 110, >5,000, 1,830, and >5,000 nM, respectively); noncompetitive inhibitor of Cav1 channels (IC50 = 30 nM); inhibits apomorphine-induced vomiting in dogs (ED50 = 0.011 mg/kg)
Cayman Chemical Dehydro AmlodIpInfumarate 10mg
A potential impurity found in commercial preparations of amlodipine; a degradation product formed during storage or when amlodipine is subjected to oxidative or acidic conditions or undergoes photo or electrochemical degradation
Cayman Chemical PardoprunoxhydrochlorIde 10mg
A dopamine D2 and D3 receptor partial agonist and 5-HT1A agonist (EC50s = 10, 0.63, and 501 nM, respectively); selective for dopamine D2, D3, and 5-HT1A receptors over a panel of neurotransmitter receptors (Kis = >1000 nM); increases contralateral turning behavior in a 6-OHDA rat model of Parkinson’s disease (ED50 = 0.03 mg/kg); reduces amphetamine-induced hyperlocomotion and induces 5-HT1A-mediated flat body posturing and lower lip retraction in rats; dose-dependently increases locomotor activity in an MPTP-induced marmoset model of Parkinson's disease when administered at doses ranging from 0.01-0.3 mg/kg
Cayman Chemical DIhydrocurcumIn 10mg
An active metabolite of curcumin; reduces triglyceride levels and increases glucose uptake in HepG2 and L-02 cellular models of oleic acid-induced steatosis at 20 µM
Cayman Chemical ZPheTyr tBudIazomethylket 10mg
An inhibitor of cathepsin L (Kinact = 200,000 M-1s-1); selective for cathepsin L over cathepsin S and cathepsin B (Kinacts = 30 and 10.3 M-1s-1, respectively); active against bloodstream forms of T. brucei brucei clone 427-221a in vitro (EC50 = 126 μM)
Cayman Chemical -OxypeucednIn hydrate 10mg
A furanocoumarin; active against a variety of bacteria and fungi (MICs = 9.76-625 UG/ml); inhibits proliferation of human MK-1 gastric and HeLa cervical cancer cells, as well as murine B16/F10 melanoma cells (EC50s = 47.2, 80.3, and 42 UG/ml, respectively); also inhibits proliferation of sensitive and multidrug-resistant L5178Y murine lymphoma cells (IC50s = 41.96 and 60.58 µM, respectively)
Cayman Chemical OrselInIc AcId 10mg
A fungal metabolite and benzoic acid derivative with antioxidant and neuroprotective activities; scavenges DPPH radicals (IC50 = 5 mM); prevents PAF-induced PARP cleavage in PC12-AC cells and PAF-induced cytotoxicity in Pafr-/-mouse cerebellar granule cells at 1 μg/ml