Custom Peptides
Cayman Chemical LY2835219 (methanesulfonate), Purity: ≥95%, CAS: 1231930-82-7, 10 mg
An orally-bioavailable dual inhibitor of CDK4 and CDK6 (IC50s = 2 and 10 nM, respectively); has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds
Cayman Chemical Esomeprazole Magnesium, Purity: ≥95%, CAS: 161973-10-0, 10 mg
A form of esomeprazole in complex with magnesium; reduces aceclofenac-induced ulcer area and lesion index in the stomach in a rat model of NSAID-induced gastric ulcer at 20 mg/kg
Cayman Chemical Aldosterone, Purity: ≥98%, CAS: 52-39-1, 10 mg
A steroid hormone secreted by the adrenal cortex that controls sodium and potassium balance
Cayman Chemical Camostat (mesylate), Purity: ≥98%, CAS: 59721-29-8, 10 mg
A protease inhibitor; inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin; inhibits entry of VSV particles pseudotyped with SARS-CoV or SARS-CoV-2 spike glycoprotein in Calu-3 cells and primary human lung epithelial cells at 50 µM; reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells; inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM); enhances mucociliary clearance in sheep; dietary administration inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis at 1 mg/kg
Cayman Chemical Shikonin, Purity: ≥98%, CAS: 517-89-5, 10 mg
A naturally occurring naphthoquinine; increases glucose uptake by adipocytes and inhibits PTEN activity; inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2; inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication; reduces joint swelling and cartilage destruction in a mouse model of collagen-induced arthritis
Cayman Chemical PAF C-16 Carboxylic Acid, Purity: ≥95%, CAS: 129879-41-0, 10 mg
Modified with a carboxylic acid group terminating the C-16 alkyl chain, providing a convenient site for chemical crosslinking
Cayman Chemical Hexanoyl Glycine, Purity: ≥95%, CAS: 24003-67-6, 10 mg
An acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation
Cayman Chemical 5-trans Prostaglandin F2α, Purity: ≥98%, CAS: 36150-01-3, 10 mg
5-trans PGF2α is the more thermodynamically stable C-5 olefin isomer of PGF2α and is a common impurity in commercial lots of PGF2α. 5-trans PGF2α administered intravenously to anesthetized rabbits caused a substantial (ten-fold) increase in respiratory rate, but this attribute was common to a number of F-series compounds and analogs.{2224}
Cayman Chemical Prostaglandin F1α, Purity: ≥98%, CAS: 745-62-0, 10 mg
PGF1α is the putative metabolite of DGLA via the COX pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M.{3467} PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α.{2058} It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.{2218}
Cayman Chemical AWD 131-138, Purity: ≥98%, CAS: 188116-07-6, 10 mg
A partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM; displays a broad spectrum of anticonvulsant activity in diverse seizure and epilepsy models without a tendency toward tolerance or abuse
Cayman Chemical DC4 Crosslinker, Purity: ≥98%, CAS: 1374647-94-5, 10 mg
A MS-cleavable crosslinking reagent (18Å in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay
Cayman Chemical 17-phenyl trinor Prostaglandin F2α ethyl amide, Purity: ≥97%, CAS: 155206-00-1, 10 mg
An F-series prostaglandin and an FP receptor agonist; induces calcium mobilization in 3T3-L1 fibroblasts expressing the human receptors (EC50 = 2.2 µM); ocular administration reduces IOP in normotensive dogs and ocular hypertensive monkeys at 0.03% w/v
Cayman Chemical Xanthosine 5'-monophosphate (sodium salt), Purity: ≥95%, CAS: 25899-70-1, 10 mg
An intermediate in purine metabolism, the product of the rate limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis.
Cayman Chemical 15-keto Latanoprost (free acid), Purity: ≥95%, CAS: 369585-22-8, 10 mg
A metabolite of latanoprost
Cayman Chemical Tenofovir Disoproxil (fumarate), Purity: ≥98%, CAS: 202138-50-9, 10 mg
A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor, tenofovir; >100-fold greater anti-HIV activity than that of poorly bioavailable tenofovir in a T cell line and primary blood lymphocytes