Custom Peptides
Cayman Chemical BlarcamesIn 10mg
A σ1 receptor agonist; inhibits reductions in mitochondrial oxygen consumption and lipid peroxidation induced by Aβ (25-35) in isolated mouse hippocampus at 1 mg/kg; improves deficits in novel object recognition induced by Aβ (25-35) in mice, as well as reduces tau phosphorylation and Aβ (1-42) levels in the hippocampus in the same model at 1 mg/kg; increases the latency to fall in the rotarod test, reduces gait impairments, and reduces increases in the mean acoustic startle response in an Mecp2-/- mouse model of Rett syndrome at 30 mg/kg per day
Cayman Chemical PaederosIdIc AcId 10mg
An iridoid glycoside; inhibits the proliferation of NCI H1650, HCC827, and A549 cells (IC50s = 40.68, 42.58, and 36.48 UG/ml, respectively); protects against PTZ- or maximal electroshock-induced seizures in mice from 10-40 mg/kg; increases duration of pentobarbital-induced sleep and decreases the latency to sleep onset in mice
Cayman Chemical AposcopolamIn 10mg
A tropane alkaloid and an active metabolite of scopolamine; selective for mAChRs over nAChRs (IC50s = 0.0192 and 188 µM, respectively)
Cayman Chemical TInptIn MetabolIte MC5 10mg
An active metabolite of tianeptine; selectively induces G protein activation in BRET assays using HEK293T cells expressing human MOR over human DOR (EC50s = 0.454 and >100 µM, respectively); decreases immobility in the forced swim test in wild-type mice, but not MOR knockout mice, indicating MOR-dependent antidepressant-like activity at 30 mg/kg
Cayman Chemical NafarelInacetate 10mg
A GNRH agonist; a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones; reduces plasma levels of luteinizing hormone and testosterone as well as testicular volume, sperm count, sperm motility, and duration of ejaculation in male dogs when administered at a doses ranging from 0.5-2 μg/kg, s.c.; inhibits estrus in female beagle dogs; reduces the volume of endometrial tissue in a rat model of endometriosis
Cayman Chemical DolutegravIr 10mg
A potent inhibitor of HIV integrase (IC50 = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro); inhibits HIV-1 viral replication (EC50 = 0.51 nM) in PMBCs; CC50 values are 189 and 52 µM in unstimulated and stimulated PBMCs; prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) that are resistant to NRTIs, NNRTIs, and protease inhibitors and impairs their ability to infect CIP4 cells
Cayman Chemical BIA 10-2474 10mg
An inhibitor of FAAH (IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme); inhibits FAAH2, ABHD6, CES2, and PNPLA6 (IC50s = 0.4, 0.081, 2, and 11 μM, respectively); alters expression of 161 lipid species, including FAAH substrates as well as other lipid classes, in human cortical neuron cultures indicating compound promiscuity
Cayman Chemical C12 CeramIded18 112 0 10mg
A naturally occurring ceramide; is formed when C12 sphingomyelin is hydrolyzed by ASM; substrate for acid ceramidase, an enzyme which has 2- to 12-fold higher activity in fibroblasts from patients with Farber disease; found in the Wharton's jelly of babies born to women with pre-eclampsia
Cayman Chemical Bentamapimod 10MG
A selective, orally bioavailable inhibitor of JNK1, JNK2, and JNK3 (IC50s = 80, 90, and 230 nM, respectively); induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis
Cayman Chemical 3-DeazaurIdIn 10mg
A nucleoside analog; converted intracellularly to 3-deazauridine triphosphate, which inhibits the biosynthesis of CTP; inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM; dose-dependently reduces mortality in a mouse model of leukemia; enhances the incorporation of decitabine into DNA in leukemia cells when used at a concentration of 20 µM; reduces mortality when used at a dose of 100 or 150 mg/kg and combined with decitabine in a mouse model of leukemia
Cayman Chemical INCB 057643 10mg
A BET family protein inhibitor; inhibits binding of BRD2, BRD3, and BRD4 to an acetylated histone H4 peptide in vitro; decreases Myc levels in, and inhibits proliferation of, AML, DLBCL, and MM cells; reduces tumor growth in AML, DLBCL, and MM mouse xenograft models; reduces tumor growth when administered alone or in combination with docetaxel or MDV 3100 in a 22Rv1 CRPC mouse xenograft model
Cayman Chemical AlflutInIbmesylate 10mg
An inhibitor of mutant EGFRs; selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR; reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 NSCLC PDX mouse model at 10 and 30 mg/kg
Cayman Chemical CInamtnIn B-1 10mg
A polyphenol antioxidant; inhibits lipid peroxidation in vitro (IC50 = 2.25 µM); improves wound healing in mice; COX-2 inhibitor with 19, 27, and 86% inhibition in Sf9 cells at 10, 100, and 1,000 UG/ml, respectively
Cayman Chemical SafInamIdemesylate 10mg
An inhibitor of MAO-B (IC50 = ~0.1 μM); selective for MAO-B over MAO-A (IC50 = >10 μM); inhibits radioligand binding to sodium channel binding site 2, sigma-1, and sigma-2 receptors in rat brain membranes (IC50s = 8.2, 0.019, and 1.59 μM, respectively); inhibits high voltage-activated calcium currents and depolarization-induced tetrodotoxin-sensitive fast sodium currents in rat hippocampal neurons; inhibits veratrine-induced glutamate release in rat hippocampal slices (IC50 = 56 μM); inhibits maximal electroshock-induced tonic extension seizures in mice and rats (ED50s = 8 and 11.8 mg/kg, p.o.) as well as maximal seizures induced by bicuculline, picrotoxin, 3-mercaptopropionic acid, and strychnine in mice (ED50s = 26.9, 60.6, 21.5, and 104.1 mg/kg, p.o., respectively)