Custom Peptides
Cayman Chemical ElaIdIc AcId-d17 10mg
An internal standard for the quantification of elaidic acid by GC- or LC-MS
Cayman Chemical HValProProOHtrIfluoroac 10mg
A peptide ACE inhibitor (IC50 = 9 µM); inhibits acetylcholine-induced NO production in HUVECs at 1 µM; induces vasorelaxation in precontracted isolated rat aortic rings; decreases systolic blood pressure in spontaneously hypertensive rats at 0.3 mg/kg; dietary administration reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, expression of Il6 and Il1b, and aortic arch intimal thickening and atherosclerotic plaque formation in ApoE-/- mice
Cayman Chemical PCMPAhydrochlorIde 10mg
A synthetic drug which is structurally related to the psychoactive compound phencyclidine; recently been identified as a likely drug of abuse
Cayman Chemical EstrIol 16a DGlucuronIde 10mg
A metabolite of estriol; plasma levels have been used as biomarkers of placental estriol production during pregnancy
Cayman Chemical Suzetrgn 10mg
A Nav1.8 inhibitor (IC50 = 0.7 nM for the human channel); selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all)
Cayman Chemical ORG 12962hydrochlorIde 10mg
A 5-HT2C receptor agonist (EC50 = 97.72 nM in a FLIPR-based intracellular calcium assay using CHO-K1 cells expressing the human receptors); selective for 5-HT2C over 5-HT2A and 5-HT2B receptors (EC50s = 419.87 and 524.81 nM, respectively)
Cayman Chemical GIsadenafIlbesylate 10mg
A PDE5 inhibitor (IC50 = 1.1 nM); 103-fold selective for PDE5 over PDE6 at 1.1 nM; restores the wild-type response to hypercapnia in the Tat-tg mouse model of HIV-1 neuroinflammation
Cayman Chemical ArecaIdIn but2ynyl ester 10mg
A muscarinic acetylcholine receptor agonist; binds to M1, M2, and M3 mChARs (pD2s = 7.93, 8.33, and 7.67, respectively); inhibits calcium channel currents in a whole-cell patch clamp assay using primary rat SPG cells (EC50 = 3.6 µM); inhibits transmural nerve stimulation-induced vasodilation in isolated and washed porcine basilar arterial rings (EC50 = 0.5 µM); reduces MAP and BPM in normotensive rats in a dose-dependent manner
Cayman Chemical SKF 82958hydrobromIde 10mg
A dopamine D1 receptor agonist (K0.5 = 4 nM in a radioligand binding assay); selective for dopamine D1 over D2 receptors (K0.5 = 73 nM); induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50 = 491 nM); prevents and reverses fentanyl-induced respiratory depression in cats at 3 mg/kg; increases locomotion and rearing in rats
Cayman Chemical 28Deoxybetuln mthylenamIn 10mg
A derivative of betulin; has been used in the synthesis of triterpene derivatives with antiviral activity
Cayman Chemical Betulonaldehyde 10mg
A pentacyclic triterpenoid; active against P. falciparum (IC50 = 3.36 UG/ml); cytotoxic to NCI H187 and Vero cells (IC50s = 19.23 and 17.09 UG/ml, respectively); reduces TPA-induced EAr edema in mice at 1 mg/ear; has also been used a precursor in the semisynthesis of C-2 and C-28 betulonic aldehyde derivatives
Cayman Chemical Ac-Gly-Lys-OMeacetate 10mg
A synthetic peptide urokinase substrate; has been used to characterize the effects of small molecule inhibitors and metal ions on urokinase activity in cell-free assays
Cayman Chemical ZINC00881524 10mg
A ROCK inhibitor; decreases levels of ROCK1 in T47D and CAMA-1 breast cancer cells; decreases proliferation of T47D and CAMA-1 cells when used in combination with CNN1 knockdown
Cayman Chemical NaltrIndolehydrochlorIde 10mg
A potent antagonist of the human δ-opioid receptor (Ki = 0.02-0.3 nM), with much lower affinities for κ- and µ-opioid receptors (Kis = 10-66 and 6-64 nM, respectively)