Custom Peptides
Cayman Chemical GalactosylcRamIdShydroxy 10mg
A sphingolipid; metabolic precursors to sulfatides; found primarily in nerve tissues; involved in cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells; accumulate in globoid cells in the brain of patients with Krabbe disease
Cayman Chemical SNBocLHomoserIn ethyl 10mg
A synthetic intermediate in the synthesis of unsaturated caprolactams and monomer units for oxy-peptide nucleic acids from the starting material L-homoserine
Cayman Chemical Sartrypyron B 10mg
A fungal metabolite; inhibits the growth of MCF-7, H460, and A375 cancer cells (GI50s = 17.8, 20.5, and 25 µM, respectively)
Cayman Chemical ChelerythrInchlorIde 10mg
A potent, cell permeable inhibitor of PKC (IC50 = 660 nM); also inhibits Bcl-xL function (IC50 = 1.5 μM), inducing apoptosis in several cancer cell lines; can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo
Cayman Chemical TrIgonlaDIoscIn 10mg
A natural steroid saponin that inhibits proliferation and induces apoptosis in cancer cells; has antioxidant activity and induces autophagy
Cayman Chemical SitosterolDglucoside 10mg
A sterol glycoside with diverse biological activities; active against E. coli and S. aureus; inhibits α-amylase and α-glucosidase and scavenges DPPH radicals (IC50s = 46.4, 17, and 155 µM, respectively); inhibits the proliferation of HepG2 and SMMC-7721 hepatocellular carcinoma cells (IC50s = 143.4 and 138.73 UG/ml, respectively) and migration and invasion in the same cells at 50 or 100 UG/ml; increases survival and decreases the number of kidney CFUs in a mouse model of candidiasis induced by C. albicans
Cayman Chemical nacardIc AcId trIen 10mg
A polyunsaturated form of anacardic acid; inhibits soybean lipoxygenase-1 (IC50 = 60 µM); inhibits superoxide production by xanthine oxidase by 82% at 88 µM; active against S. mutans, S. aureus, and MRSA ATCC 33591 (MICs = 1.56, 6.25, and 6.25 UG/ml, respectively); inhibits NADH oxidase (IC50 = 1.3 UG/ml); toxic to B. glabrata (LC50 = 0.35 ppm)
Cayman Chemical L-CarnItIn-d3chlorIde 10mg
An internal standard for the quantification of L-carnitine by GC- or LC-MS
Cayman Chemical ArtemIsInIc AcId 10mg
A sesquiterpene; decreases triglyceride levels and GPDH activity in hAMSCs; inhibits adipocyte differentiation at 200 µM; decreases C/EBPα and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes
Cayman Chemical ChlorntrnIlIprole 10mg
An anthranilic diamide insecticide and ryanodine receptor agonist; stimulates release of calcium from intracellular stores in insects (EC50s= 40-50 nM for P. americana neurons and H. virescens or D. melanogaster recombinant ryanodine receptors); selective for insect over mammalian ryanodine receptors (EC50s = 14,000 nM, >100 µM, and >100 µM for C2C12 mouse, PC12 rat, and IMR32 human cells, respectively); active against larvae of the order Lepidoptera (EC50s = 0.02, 0.01, and 0.05 ppm for the fall armyworm, diamondback moth, and tobacco budworm, respectively)
Cayman Chemical N 1CarboxymethylLlysIn 10mg
An AGE, produced by the oxidative modification of glycated proteins during oxidative stress; increases with aging and during pathologies marked by oxidative stress; activates RAGE, triggering signaling through MAPKs and NF-κB
Cayman Chemical methyl1 cyclohexylmethyl1 10mg
An analog of BB-22 that lacks the quinoline group; intended for forensic and research applications
Cayman Chemical Phenprocoumon 10mg
An anticoagulant and vitamin K antagonist; inhibits the activity of wild-type VKOR (IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays; inhibits prothrombin complex synthesis in rats in a dose-dependent manner
Cayman Chemical Upadacitinib 10mg
A JAK1 inhibitor (IC50 = 47 nM); selective for JAK1 over JAK3 and Tyk2 (IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, ROCK1, and ROCK2 (IC50s = 120, 920 and 430 nM, respectively); decreases cytokine-induced STAT phosphorylation in a variety of human cells (IC50s = 1.6-649 nM); reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis at 1, 3, and 10 mg/kg twice per day for 17 days