Custom Peptides
Cayman Chemical DIoctnoyl Glycol 10mg
A DGK inhibitor (Ki = 58 μM); reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets at 30, 100, and 500 μM
Cayman Chemical LIgustroflavon 10mg
An apigenin triglycoside with diverse biological activities; increases PTH release from rat primary parathyroid gland cells at 1 µM and inhibits calcium influx in HEK293 cells; increases serum PTH, as well as serum and bone calcium levels, in a streptozotocin-induced mouse model of diabetes with osteoporosis at 5 and 20 mg/kg three times per week; reduces increases in the expression and levels of CaSR in the kidney of diabetic osteoporotic mice; decreases infarct volume in a rat model of ischemic stroke at 10, 30, and 60 mg/kg and decreases the levels of the necroptosis-associated proteins RIPK3 and MLKL in the brain of ischemic rats at 30 mg/kg
Cayman Chemical 3 4-MDPAhydrochlorIde 10mg
A lesser known psychoactive substituted amphetamine of the phenethylamine class that has been used as an internal standard for qualitative and quantitative analyses of hallucinogenic designer drugs in biological samples; intended for forensic and research purposes
Cayman Chemical Gap 27trIfluoROCTAte salt 10mg
A connexin-mimetic peptide; reduces survival of isolated rat osteoclasts at 500 µM; decreases bone resorption in rat bone slice and osteoclast co-cultures; accelerates wound closure and stratification of the corneal epithelium in isolated human corneas; reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of AV-shunt surgery-induced high-output heart failure
Cayman Chemical t232trIfluoroacetAT salt 10mg
A synthetic peptide derivative of somatostatin; binds to somatostatin receptors in isolated rat synaptosomal membranes (IC50 = ~0.1 nM); inhibits the proliferation of P388 murine and HL-60 human leukemia cells at 30 and 60 UG/ml; reduces tumor volume in an HL-60 mouse xenograft model from 3-12 UG/animal per day; inhibits capsaicin-induced intradermal neutrophil accumulation and EAr edema in rats; inhibits mechano-nociceptive hyperalgesia in rats from 5-20 UG/kg, i.p.
Cayman Chemical Rabeprazole sulfon 10mg
A metabolite of rabeprazole; has been found as an impurity in bulk preparations of rabeprazole
Cayman Chemical Cordyceps mIlItarIs 10mg
A nucleoside analog with diverse biological activities; is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis; incorporates into DNA and RNA in SK-HEP-1 cells; is active against B. subtilis at 0.1-1 mg/ml; increases IL-10 secretion and mRNA expression in isolated human PBMCs at 24 UG/ml; increases survival of mice infected with C. albicans or C. krusei at 1 mg/kg per day
Cayman Chemical NicotinamID MononucleotID 10mg
An intermediate in the biosynthesis of NAD+ that has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in Nampt+/- mice and high-fat diet-induced type 2 diabetes mice
Cayman Chemical JWH 018 N 4oxopentyl meta 10mg
A potential metabolite of JWH 018, characterized by a carbonyl group at the 4 position of the alkyl chain; intended for forensic and research applications
Cayman Chemical ThonzonIumbromIde 10mg
A quaternary ammonium-containing cationic surfactant with diverse biological activities; an inhibitor of F. tularensis AcpB (Ki = 0.59 µM) and C. albicans V-ATPase (EC50 = 69 µM); inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs; inhibits bone resorption by mature osteoclasts at 100 and 200 nM; prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day; induces mortality in C. oncophora, O. ostertagi, H. contortus, and T. circumcincta (EC50s = 4.5, 10.8, 5.1, and 6.7 µM, respectively) but is cytotoxic to HEK293 and RAW 264.7 cells (CC50s = 9.2 and 5.7 µM, respectively)
Cayman Chemical MRT67307hydrochlorIde 10mg
A kinase inhibitor that inhibits TBK1, MARK1-4, IKKε, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), SIKs (IC50s = 250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively)
Cayman Chemical PIclIdenoson 10mg
An adenosine A3 receptor agonist (Ki = 1.7 nM); selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively); reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion at 100 UG/kg; reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and the number of lung metastases in a model of metastatic murine melanoma; reduces colonic inflammatory cell infiltration and damage in a mouse model of DSS-induced colitis and in in IL-10-/- mice at 1 and 3 mg/kg
Cayman Chemical SCIADOPITYSIN 10MG
A biflavonoid with diverse biological activities; reduces Aβ42-induced cytotoxicity in PC12 cells (EC50 = 9.84 μM); decreases methylglyoxal-induced insulin secretion, production of ROS, cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells from 0.1-10 μM; inhibits P-gp (IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells; inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss
Cayman Chemical HexnoylCoenzyme AsodIum s 10mg
A medium-chain fatty acyl CoA; the preferred acyl donor substrate for GOAT; a precursor in the biosynthesis of olivetolic acid
Cayman Chemical 4 5-DIcaffeoylquInIc AcId 10mg
A polyphenol with diverse biological activities; inhibits HIV-1 integrase 3' end processing, 3’ end joining, and disintegration (IC50s = 0.13, 0.24, and 0.3 μg/ml, respectively); inhibits HIV-1 replication in MT-2 T lymphoblastoid cells (EC50 = 2 UG/ml); scavenges DPPH radicals in a cell-free assay (IC50 = 19.8 µM) and inhibits superoxide production in human neutrophils activated by fMLF and cytochalasin B (IC50 = 1.49 µM); decreases PGE2 production in LPS-stimulated U937 cells at 5 and 10 UG/ml but increases it at 200 UG/ml and increases TNF-α production at 5-200 UG/ml; inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis in B16F1 murine melanocytes at 25 µM