Custom Peptides
Cayman Chemical 3EthylethcathInonhydrochl 10mg
A substituted cathinone with potential for abuse; intended for forensic applications
Cayman Chemical CalIcheamIcIn 1 10mg
A polyketide enediyne; induces double-stranded DNA scission in cell-free assays
Cayman Chemical 4EthylethcathInonhydrochl 10mg
A substituted cathinone with potential for abuse; intended for forensic applications
Cayman Chemical SulfosucInImIdyl MyrIstat 10mg
An inhibitor of fatty acid transport that has been used as an affinity label for certain membrane proteins that bind to fatty acids
Cayman Chemical SImurosertIb 10mg
An inhibitor of Cdc7 kinase (IC50 = 0.26 nM); selective for Cdc7 over Cdk2 and ROCK1 (IC50s = 6,300 and 430 nM, respectively); inhibits phosphorylation of MCM2 in HeLa cells (IC50 = 17 nM); reduces proliferation of COLO 205 cells (EC50 = 81 nM); inhibits the growth of a wide variety of cancer cells (GI50s = 30.2->10,000 nM); reduces intratumor levels of phosphorylated MCM2 in COLO 205 and SW948 mouse xenograft models at 80 mg/kg and reduces tumor growth in the same models when administered at doses of 40 or 60 mg/kg twice per day
Cayman Chemical 6methoxy Naphthalen ACtIc 10mg
6-MNA is a competitive, non-selective COX inhibitor.{1286,1364,1791} The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.{1364} The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.{1286}
Cayman Chemical nglada oxbugna ngltn 10mg
A flavonoid glycoside; scavenges ABTS radicals in a cell-free assay (IC50 = 18.13 UG/ml); induces apoptosis in MCF-7 and MDA-MB-231 human breast cancer cells at 2 UG/ml; inhibits LPS-induced production of IL-1β, IL-6, and NO in isolated rat chondrocytes, as well as reduces cartilage erosion and the loss of proteoglycan in the inflamed joints in a rat model of surgically induced osteoarthritis
Cayman Chemical Asprgls fumIgatus Fumagln 10mg
A fungal metabolite with diverse biological activities; inhibits METAP2 (IC50 = 10 nM); inhibits tube formation in a rat blood vessel organ culture assay at 10 ng/ml; inhibits E. cuniculi replication in isolated rabbit kidney cells and canine embryo cells at 5 UG/ml; decreases tumor growth and the number of metastases in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma at 30 mg/kg; reduces subcutaneous and gonadal fat mass in a mouse model of high-fat diet-induced obesity
Cayman Chemical 8-AzaadenosIn 10mg
A nucleoside analog and an ADAR1 inhibitor; inhibits RNA A-to-I editing in, as well as the invasion and migration of, TPC-1 and Cal-62 thyroid cancer cells at 1 and 2 µM; increases the ex vivo secretion of IFN-γ and TNF-α from CD8+ T cells isolated from mouse spleen in a model of HBV infection at 2 mg/kg; decreases serum HBsAg levels in the same model
Cayman Chemical nondrographolIde 10mg
A principle diterpenoid isolated from A. paniculata that inhibits LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM); reduces VEGF-induced proliferation of HUVECs; inhibits furin with an IC50 value of 53.5 µM
Cayman Chemical 2-trns-HexadecenoIc AcId 10mg
An intermediate formed in the β-oxidation of palmitic acid
Cayman Chemical SulfaethoxypyrIdazIn 10mg
A sulfonamide antibiotic; active against several strains of E. coli isolated from necropsied animals or poultry at 0.25 or 1 mg/ml; induces the formation of cataracts in dogs when administered at 150 mg/kg for 13-27 weeks
Cayman Chemical GemcItabIn ElaIdate 10mg
A prodrug form of gemcitabine; inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells or gemcitabine-resistant AG6000 cells; reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models at 40 mg/kg every three days
Cayman Chemical WKYMVmtrIfluoROCTAte salt 10mg
A synthetic peptide agonist of FPR1 and FPR2; induces calcium mobilization in ETFR cells transfected with FPR1 or FPR2 at 0.1 nM; stimulates chemotaxis of monocytes, dendritic cells, and NK cells, as well as superoxide production in monocytes and neutrophils, in vitro; reverses mucosal destruction, decreases in body weight, and colonic shortening in a mouse model of DSS-induced colitis at 8 mg/kg; topical application stimulates angiogenesis and accelerates re-epithelialization and granulation tissue formation in a rat model of diabetic cutaneous wounds