Nucleosides
5-Methylcytidine, 98%, Thermo Scientific™
BD Bromodeoxyuridine (BrdU)
A thymidine analog used in cell proliferation studies
Fialuridine, Thermo Scientific™
Medchemexpress LLC Nucleoside-Analog-1 | 876707-99-2 | 95.0% | C9H9N5O5 | 100 MG
Nucleoside-Analog-1 is a click chemistry reagent containing an azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that have alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Click chemistry reagent with an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
- Purity of 95.0%
- Molecular formula C9H9N5O5
- Appearance: White to off-white solid
- Related to anti-infection and cell cycle/DNA damage pathways
- Associated with disease areas like cancer, infection, and hepatitis C virus infection
Medchemexpress LLC 3-Methyluridine | 2140-69-4 | 99.05% | 258.23 | 1 ML
3-Methyluridine (m3U) is a methylated nucleotide found in ribosomal RNA (rRNA), primarily targeting specific base sites like 23S rRNA. It introduces a methyl group at the N3 position of uracil, influencing RNA's secondary structure stability and base pairing. This regulation impacts ribosome function, including ribosomal subunit binding and tRNA interaction.
- Utilized as a key raw material for synthesizing modified nucleotides.
- Constructs RNA oligonucleotides with methylation modifications.
- Used in studying the effects of RNA methylation on gene expression and drug resistance.
Medchemexpress LLC Nucleoside-analog-1 | 876707-99-2 | 95.0% | C9H9N5O5 | 2 MG
Nucleoside-Analog-1 is a click chemistry reagent. It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Contains an azide group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Compatible with molecules containing alkyne groups
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC)
- Compatible with molecules containing DBCO or BCN groups
Medchemexpress LLC Pseudouridine | 1445-07-4 | 99.9% | 244.20 | 1 ML
Pseudouridine is an isomer of uridine, the most abundant modified nucleoside found in non-coding RNA. It plays a crucial role in fine-tuning and stabilizing regional structures in rRNA and tRNA, essential for mRNA decoding, ribosome assembly, processing, and translation. This modification provides an additional hydrogen bond donor at its non-Watson-Crick edge, giving it distinct chemical properties and maintaining its function as the 'fifth nucleotide' across all phylogenetic domains of life.
- Most abundant modified nucleoside in non-coding RNA.
- Essential for mRNA decoding, ribosome assembly, processing, and translation.
- Provides an additional hydrogen bond donor.
- Present across all phylogenetic domains of life.
- Modified tRNA fragments may inhibit aberrant protein synthesis.
- Stabilizes RNA and improves base stacking.
Apexbio Technology LLC 4-Thio-dTTP 10ul (100 mM)
4-Thio-dTTP is a nucleotide analog structurally similar to thymidine triphosphate (dTTP) It incorporates into DNA strands during enzymatic synthesis modifying nucleic acid interactions and affecting the activities of enzymes involved in DNA replication and repair 4-Thio-dTTP exerts its biological activity through incorporation into DNA enabling the study of DNA polymerase fidelity replication kinetics enzyme-substrate interactions and mechanisms of DNA damage responses Based on these biochemical properties 4-Thio-dTTP holds research potential in applications such as investigating DNA synthesis regulation enzymatic mechanisms and pathways related to cancer and genomic instability
Medchemexpress LLC Trifluridine | 70-00-8 | MFCD00006534 | 99.9% | C10H11F3N2O5 | 1 ML
Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor that suppresses DNA synthesis. It is an antiviral molecule used in research for HSV, rhabdovirus, and orthopoxvirus infections. Trifluridine induces cell apoptosis and autophagy. It also functions as an anticancer agent for studies involving metastatic colorectal cancer and gastrointestinal tumors.
- Irreversible and orally active thymidylate synthase inhibitor
- Suppresses DNA synthesis
- Antiviral for HSV, rhabdovirus, and orthopoxvirus infections
- Induces cell apoptosis and autophagy
- Functions as an anticancer agent for metastatic colorectal cancer and gastrointestinal tumors
- Inhibits proliferation in various cancer cell lines
- Shows antitumor activity in human colorectal intraperitoneal xenograft model
Medchemexpress LLC Nucleoside-Analog-2 | 876708-01-9 | ≥95.0% | C9H11N5O6 | 100 MG
Nucleoside-Analog-2 is a 4'-Azidocytidine analogue primarily designed to act against Hepatitis C virus (HCV) replication. It functions as a versatile click chemistry reagent, featuring an Azide group, which enables participation in both copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Acts against hepatitis C virus (HCV) replication
- Functions as a click chemistry reagent
- Contains an azide group for CuAAc reactions with alkyne-containing molecules
- Undergoes SPAAC reactions with DBCO or BCN group-containing molecules
- Intended for research use only
Medchemexpress LLC Nucleoside-Analog-2 | 876708-01-9 | ≥95.0% | C9H11N5O6 | 1 ML
Nucleoside-Analog-2 is a 4'-Azidocytidine analogue effective against Hepatitis C virus (HCV) replication. It functions as a click chemistry reagent containing an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This product is intended for research use only.
- 4'-Azidocytidine analogue
- Active against Hepatitis C virus (HCV) replication
- Click chemistry reagent
- Contains an Azide group
- Can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions