Bioactive Small Molecules
Cayman Chemical 6-AmInophenthrIdIn 5mg
An antiprion agent; inhibits prion formation in yeast- and mammalian-based screening assays; inhibits protein folding activity of the ribosome at 300 µM; directly competes with protein substrates for the ribosome active site and decreases the yield of refolded protein without affecting the rate of refolding; prevents progressive wing position defects in a Drosophila model of OPMD at 300-400 µM in larvae and 1-3 mM in adults
Medchemexpress LLC Ethacrynic acid (Standard) | 58-54-8 | 98.8% | 25 MG
Ethacrynic acid (Standard) is the analytical standard of Ethacrynic acid, intended for research and analytical applications. It is a diuretic and an inhibitor of glutathione S-transferases (GSTs). It also acts as a potent inhibitor of the NF-κB-signaling pathway, modulates leukotriene formation, and inhibits L-type voltage-dependent and store-operated calcium channels, leading to relaxation of airway smooth muscle (ASM) cells. This compound possesses anti-inflammatory properties that reduce retinoid-induced ear edema in mice.
- Analytical standard
- Intended for research and analytical applications
- Diuretic
- Inhibitor of glutathione S-transferases (GSTs)
- Potent inhibitor of NF-κB-signaling pathway
- Modulates leukotriene formation
- Inhibits L-type voltage-dependent and store-operated calcium channel
- Anti-inflammatory properties (reduces retinoid-induced ear edema in mice)
Apexbio Technology LLC Oxymatrine 16837-52-8 500mg
Oxymatrine (CAS 16837-52-8) is a quinolizidine alkaloid extracted from Sophora flavescens It has been shown to modulate multiple cellular pathways associated with fibrosis and neurodegeneration including inhibition of TGF- 1-mediated signaling and reduction of pro-inflammatory cytokine expression Oxymatrine exhibits antifibrotic and neuroprotective properties in various experimental models It is also extensively studied for its antiviral activity against hepatitis B virus and has been applied in traditional Chinese medicine for hepatitis management This compound is valuable for investigating mechanisms of fibrosis neuroprotection and viral pathogenesis
Apexbio Technology LLC SAR407899 923359-38-0 10mg
SAR407899 (CAS 923359-38-0) is an ATP-competitive inhibitor that selectively targets the ROCK-2 isoform of Rho-associated protein kinases It demonstrates an IC50 of 135 nM for ROCK-2 and binds with Ki values of 36 nM and 41 nM for human and rat ROCK-2 respectively Through selective modulation of the ROCK signaling pathway SAR407899 has been shown to sustain inhibition of migration complex formation in cellular models This compound is thus suited for investigating cell migration cytoskeletal reorganization and the functional role of ROCK signaling in biomedical research
Apexbio Technology LLC Piromidic Acid 19562-30-2 50mg
Piromidic acid (CAS 19562-30-2) is a small-molecule inhibitor targeting bacterial DNA gyrase It is designed to inhibit DNA gyrase activity thereby disrupting bacterial DNA replication and cell proliferation Piromidic acid exerts its biological activity primarily through inhibition of bacterial DNA gyrase In in vitro studies piromidic acid demonstrates antibacterial activity with reported IC50 values for DNA gyrase inhibition in the low micromolar range dependent on the bacterial strain and assay conditions Based on these pharmacological properties piromidic acid holds research potential in investigating bacterial susceptibility resistance mechanisms and DNA gyrase function especially in the context of pathogens responsible for intestinal biliary and urinary tract infections
Medchemexpress LLC PUMA BH3 | 98.2% | 2384.63 | 1 MG
PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acting as a direct activator of Bak, with a Kd of 26 nM. It binds to Bak in the canonical BH3-binding groove and activates Bak.
- Acts as a direct activator of Bak
- Kd of 26 nM
- Solid appearance
- White to off-white color
- Soluble in DMSO at 100 mg/mL
Cayman Chemical ANTIBODY ISX-9 25mg
A small molecule inducer of adult neural stem cell differentiation; 2.5-20 µM triggers neurogenesis and blocks gliogenesis in HCN cells through a neurotransmitter-mediated calcium signal and myocyte-enhancer factor 2-dependent gene expression pathway
Cayman Chemical SenkyunolIde I 5mg
A phthalide with diverse biological activities; inhibits TNF-α-induced NF-κB reporter gene expression in HEK293 cells and reduces LPS-induced IL-8 and IL-6 production in THP-1 cells at 100 µM; reduces acetic acid-induced writhing and increases the latency to paw withdrawal in the hot plate test in mice at 32 mg/kg; increases survival, decreases plasma levels of TNF-α, IL-1β, and IL-6, and protects against cognitive dysfunction in a mouse model of CLP-induced sepsis at 36 mg/kg
Medchemexpress LLC Desglymidodrine 10mg | 3600-87-1 | 10 MG
Desglymidodrine is the active metabolite of midodrine and a selective α1-adrenoceptor agonist supplied as an off-white to light yellow solid for research use. It has molecular formula C10H15NO3, molecular weight 197.23 g/mol, and reported purity of 97.33%.
- Selective α1-adrenoceptor agonist.
- Active metabolite of midodrine.
- Off-white to light yellow solid form.
- Molecular formula C10H15NO3 and molecular weight 197.23 g/mol.
- Purity reported as 97.33%.
- Store at 4°C and protect from light; in solution store frozen as recommended.
- Supplied as a 10 mg research reagent suitable for in vitro studies.
Cayman Chemical ANTIBODY SenIcapoc 500mg
An inhibitor of IKCa1/KCa3.1 channels; inhibits A23187-induced rubidium efflux from and dehydration of isolated human RBCs (IC50s = 11 and 30 nM, respectively); reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease at 10 mg/kg twice per day; inhibits production of IL-2, IFN-γ, IL-12, and IL-17A in PMA- and ionomycin-stimulated CD3+ T cells at 1 μM; increases the paw withdrawal threshold in a rat model of CCI of the sciatic nerve at 100 mg/kg
Medchemexpress LLC Vacuolin-1 | 351986-85-1 | 98.5% | 577.42 g/mol | C26H24IN7O | 100 MG
Vacuolin-1 is a cell-permeable small molecule inhibitor used in research to block Ca2+-dependent lysosomal exocytosis and inhibit PIKfyve, disrupting endosomal-lysosomal trafficking and late-stage autophagy. It is commonly used to study lysosomal maturation, autophagy, and cellular trafficking processes.
- Selective inhibitor of PIKfyve and lysosomal exocytosis.
- Cell-permeable small molecule suitable for cellular trafficking studies.
- Impedes late-stage autophagy by disrupting lysosomal maturation.
- Induces vacuole formation and can increase cellular enucleation.
- Reported high purity for consistent experimental results.
Medchemexpress LLC BMS 182874 | 153042-42-3 | 99.9% | 345.42 g·mol⁻¹ | C17H19N3O3S | 10 MG
BMS-182874 is a selective endothelin ETA receptor antagonist used as a research compound in cardiovascular and pulmonary pharmacology. It is supplied as a high-purity solid suitable for in vitro assays and preclinical pharmacology studies.
- Selective ETA receptor antagonist with reported IC50 0.150 μM and Ki 0.055 μM.
- High reported purity (~99.9%).
- Supplied as a solid in a 10 mg quantity.
- Intended for use in cardiovascular and hypertension research models.
- For research use only; not for human or veterinary use.
Cayman Chemical BAY-2416964 25mg
An AhR antagonist (IC50 = 22 nM in U87 cells); decreases kynurenic acid-induced mRNA expression of CYP1A1 and AHRR in LPS-stimulated isolated human monocytes at 100 nM; increases CD3-, CD28-, and IL-2-induced IFN-γ production in isolated human naïve CD4+ T cells from 30-1,000 nM; reduces tumor volume, increases CD8+ T cell and NK cell tumor infiltration, and decreases GR1+ myeloid cell and CD206+ M2 macrophage tumor infiltration in a B16/F10-OVA murine melanoma model at 30 mg/kg, p.o.
Abcam LM22A-4, neurotrophic BDNF mimetic, 10MG
MW 339.34 Da, Purity >98%. Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC₅₀ = 47 nM) in binding assays. Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of neurodegenerative disease. Causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats, after in vivo administraton. Improves respiratory function in a mouse model of Rett syndrome.
The product is subject to the following: Abcam Restricted Use Statement