Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,561 – 4,575 of 60,538 results

4,561

Cayman Chemical CAY10748, Purity: ≥98%, CAS: 2412902-55-5, 10 mg

A STING agonist (IC50 = 0.3794 µM in a competition binding assay); activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay); activates the STING-TBK1-IRF3 signaling pathway; increases the secretion of IFN-β and the levels of CXCL10 and IL-6 in PBMCs at 10 µM; reduces tumor growth in a CT26 murine colon cancer model at 0.15, but not 1.5, mg/kg

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4,562

Medchemexpress LLC Activin receptor-like kinase 1 (ALK-1), cynomolgus, His-tag | 98.0% | 2 UG

Recombinant activin receptor-like kinase 1 (ALK-1) extracellular domain from cynomolgus, expressed in HEK293 cells with a C-terminal His tag. Supplied as a 2 μg research reagent with high purity for use in biochemical and binding studies.

Recombinant extracellular domain (D22-Q118).
Expressed in HEK293 mammalian cells for native glycosylation.
C-terminal His tag for detection and purification.
Supplied as 2 μg for small-scale assays.
High purity of 98.0% for reliable results.
Suitable for binding studies, biochemical assays, and antibody validation.

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4,563

Cayman Chemical L-Proline, Purity: ≥95%, CAS: 147-85-3, 1 kg

A nonessential amino acid; a substrate for PAT1; an inhibitor of AChE (Ki = 86 µM); accumulates in plants under environmental stress and is important for tolerance to environmental stress

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4,564

Cayman Chemical ICI 63197, Purity: ≥98%, CAS: 27277-00-5, 500 mg

A PDE3 and PDE4 inhibitor (Kis = 9 and 10 µM, respectively); selective for PDE3 and PDE4 over PDE1 and PDE2 (Kis = 487 and >1,000 µM, respectively); inhibits acetylcholine-induced bronchospasm in isolated guinea pig lungs and histamine-induced bronchospasm in conscious guinea pigs; decreases motor activity and rectal temperature and induces forepaw shaking, head twitches, and grooming in rats

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4,565

Cayman Chemical Ospemifene, Purity: ≥98%, CAS: 128607-22-7, 250 mg

A selective estrogen receptor modulator; binds to ERα and ERβ (Kis = 380 and 410 nM, respectively); increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause; increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits 17β-estradiol-induced, estrogen response element-mediated transactivation in a reporter assay using MCF-7 cells

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4,566

Medchemexpress LLC Hexadecanamide-13,13,14,14,15,15,16,16,16-d9, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)] | 2260669-53-0 | 99.0% | 564.97 | C34H60D9NO4 | 5 MG

CER3-d9 is a deuterium-labeled analogue of CER3 supplied for research use as a tracer or internal standard in quantitative analyses. Supplied as a solid in a 5 mg package, it provides high chemical and isotopic purity suitable for analytical workflows including NMR, GC-MS, and LC-MS.

Deuterium-labeled analogue useful as tracer or internal standard
High purity and isotopic enrichment for accurate quantitation
Suitable for NMR, GC-MS, and LC-MS applications
Provided as a solid in a small, research-scale package
Intended for research use only and not for human use

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4,567

Medchemexpress LLC DS18561882 | 2227149-22-4 | 99.9% | 100 MG

DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. It also demonstrates an inhibitory effect on MTHFD1 (IC50=0.57 μM) and exhibits a good oral pharmacokinetic profile. This compound, with a molecular weight of 608.63 and formula C28H31F3N4O6S, appears as a white to yellow solid. It has potential anti-tumor activity by inhibiting tumor growth in a dose-dependent manner.

Inhibits MTHFD2 and MTHFD1
Reduces cell viability in MDA-MB-231 cell lines
Inhibits tumor growth in mouse models
Used to study cisplatin-mediated apoptotic cell death
Applied in histological analysis to alleviate pulmonary fibrosis
Suitable for assessing HSC numbers and ferroptosis susceptibility

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4,568

Apexbio Technology LLC Pneumocandin B0 135575-42-7 1mg

Pneumocandin B0 (CAS 135575-42-7) is a small-molecule inhibitor targeting -(1 3)-D-glucan synthase It is designed to inhibit this enzyme thereby disrupting fungal cell wall biosynthesis Pneumocandin B0 exerts its biological activity primarily through inhibition of -(1 3)-D-glucan synthase In experimental studies Pneumocandin B0 demonstrates effective inhibition across multiple fungal strains with IC50 values typically observed in the low nanomolar range Based on these pharmacological properties Pneumocandin B0 holds research potential as a reference compound for studying fungal cell wall biosynthesis pathways and as a lead compound in antifungal drug discovery programs

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4,569

Cayman Chemical Scopoletin, Purity: ≥98%, CAS: 92-61-5, 50 mg

A natural coumarin that binds iron; inhibits aldose reductase activity in galactose-fed rats, upregulates PPARγ expression, and triggers phosphorylation of Nrf2 in animals

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4,570

Cayman Chemical GLS4, Purity: ≥98%, CAS: 1092970-12-1, 25 mg

An antiviral agent; inhibits replication of wild-type HBV and drug-resistant HBV strains rtA181T, rtA181V, and rtN236T (IC50s = 146, 145, 161, and 131 nM, respectively); inhibits the formation of viral capsids and decreases viral core protein levels in HBV-infected HepG2 and HepG2.2.15 cells at 1 and 10 µM; inhibits HBV replication and reduces the levels of viral intracellular core antigens in mice inoculated with HepAD38 cells at 7.5-60 mg/kg

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4,571

Medchemexpress LLC N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-thiadiazol-5-yl)-L-prolinamide | 873652-48-3 | MFCD26142660 | 99.7% | 498.64 | C25H34N6O3S | 5 MG

GDC-0152 is a small-molecule inhibitor of inhibitor of apoptosis proteins (IAPs) used in research to probe apoptosis signaling. It selectively binds BIR domains of XIAP, cIAP1, cIAP2, and ML-IAP with low-nanomolar affinity and is supplied as a stable powder for laboratory use.

Pan-IAP inhibitor targeting BIR domains of XIAP, cIAP1, cIAP2, and ML-IAP.
Low-nanomolar Ki values: 28 nM (XIAP), 17 nM (cIAP1), 43 nM (cIAP2), 14 nM (ML-IAP).
Soluble in DMSO and ethanol at 50 mg/mL; ultrasonic assistance may be required.
Powder storage recommended at -20°C for long-term stability; in-solution storage at -80°C where applicable.
For research use only; not for clinical applications.

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4,572

Cayman Chemical PD 150606, Purity: ≥98%, CAS: 179528-45-1, 5 mg

A selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2))

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4,573

Cayman Chemical Tetrahydromagnolol, Purity: ≥98%, CAS: 20601-85-8, 5 mg

An agonist of CB1 and CB2 and antagonist of GPR55 (KB = 13.3 µM in a β-arrestin translocation assay); a major metabolite of magnolol; binds to the CB1 and CB2 receptors (Kis = 2.26 and 0.416 µM, respectively); inhibits forskolin-induced cAMP accumulation (EC50 = 9.01 and 0.17 µM, respectively); reduces melanin biosynthesis, as well as decreases tyrosinase protein levels by inhibiting tyrosinase maturation and increasing the rate of its degradation

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4,574

Medchemexpress LLC AMZ30 | 1313613-09-0 | 99.2% | 1 ML

AMZ30 is a selective protein phosphatase methylesterase-1 (PME-1) inhibitor, demonstrating significant selectivity over other serine hydrolases. It reduces the demethylated form of PP2A in living cells, attenuates muscle cell differentiation, and enhances the resistance of glioblastoma cells to oxidative stress, making it suitable for glioblastoma research.

Selective protein phosphatase methylesterase-1 (PME-1) inhibitor
>100-fold selectivity compared to other serine hydrolases
Reduces demethylated form of PP2A in living cells
Attenuates muscle cell differentiation
Increases resistance to t-BHP-induced oxidative stress in glioblastoma cells
Can be used for glioblastoma research

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4,575

Cayman Chemical Oseltamivir Acid methyl ester, Purity: ≥95%, CAS: 208720-71-2, 5 mg

A prodrug form of oseltamivir acid

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Bioactive Small Molecules

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Medchemexpress LLC Activin receptor-like kinase 1 (ALK-1), cynomolgus, His-tag | 98.0% | 2 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Hexadecanamide-13,13,14,14,15,15,16,16,16-d9, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)] | 2260669-53-0 | 99.0% | 564.97 | C34H60D9NO4 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DS18561882 | 2227149-22-4 | 99.9% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-thiadiazol-5-yl)-L-prolinamide | 873652-48-3 | MFCD26142660 | 99.7% | 498.64 | C25H34N6O3S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC AMZ30 | 1313613-09-0 | 99.2% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Activin receptor-like kinase 1 (ALK-1), cynomolgus, His-tag | 98.0% | 2 UG

Medchemexpress LLC Hexadecanamide-13,13,14,14,15,15,16,16,16-d9, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)] | 2260669-53-0 | 99.0% | 564.97 | C34H60D9NO4 | 5 MG

Medchemexpress LLC DS18561882 | 2227149-22-4 | 99.9% | 100 MG

Medchemexpress LLC N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-thiadiazol-5-yl)-L-prolinamide | 873652-48-3 | MFCD26142660 | 99.7% | 498.64 | C25H34N6O3S | 5 MG

Medchemexpress LLC AMZ30 | 1313613-09-0 | 99.2% | 1 ML