Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical CPYPP, Purity: ≥98% (mixture of isomers), CAS: 310460-39-0, 50 mg
An inhibitor of DOCK2 (IC50 = 22.8 µM for its GEF activity), DOCK5, and DOCK180; selective for these DOCKs over DOCK9; prevents chemokine-induced Rac activation in T and B cells at 100 µM; reduces migration of T cells to peripheral lymph nodes in mice at 5 mg/animal following adoptive transfer of spleen cells from knock-in mice expressing GFP-tagged DOCK2; reduces MPO activity in lung tissue, LPS-induced cytokine release in serum, and lung injury severity in a mouse model of endotoxemia-induced acute lung injury at 250 mg/kg
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Medchemexpress LLC VUF11207 fumarate | 1785665-61-3 | 99.9% | 586.65 | 1 ML
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VUF11207 fumarate is an agonist of CXCR7, a C-X-C motif chemokine receptor. It specifically binds to CXCR7 and has been shown to reduce CXCL12-mediated osteoclastogenesis and bone resorption. This reduction is achieved by inhibiting ERK phosphorylation. It is intended for research use only.
- Binds specifically to CXCR7
- Reduces osteoclastogenesis
- Decreases bone resorption
- Functions by inhibiting ERK phosphorylation
- High purity: 99.9%
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Cayman Chemical D-threo-Biopterin, Purity: ≥98%, CAS: 13019-52-8, 5 mg
A pterin; enhances luminol chemiluminescence induced by the oxidant chloramine-T in a cell-free assay at 100 μM
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Sigma Aldrich Fine Chemicals Biosciences Matrine | 519-02-8 | MFCD00210527 | 100MG
Matrine | Mol Wt: 248.36 | 519-02-8 | MFCD00210527 | 100MG
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Apexbio Technology LLC Vatalanib (PTK787) 2HCl 212141-51-0 10mg
Vatalanib (PTK787) 2HCl (CAS 212141-51-0) is a small molecule inhibitor targeting vascular endothelial growth factor (VEGF) receptor tyrosine kinases including VEGFR/KDR (IC50 0 037 M) VEGFR/Flt-1 (IC50 0 077 M) and VEGFR/Flk (IC50 0 27 M) It also inhibits other receptor tyrosine kinases such as PDGFR- (IC50 0 58 M) c-Kit (IC50 0 73 M) and c-Fms (IC50 1 4 M) Through blockade of these pathways Vatalanib suppresses VEGF-mediated signaling and angiogenesis It is utilized in research investigating mechanisms of angiogenesis and has potential applications in studies of solid tumors and other angiogenesis-dependent diseases
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Medchemexpress LLC Dehydroascorbic acid | 490-83-5 | 95.0% | 174.11 | 1 ML
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Dehydroascorbic acid is an oxidized form of vitamin C that can cross the blood-brain barrier (BBB). It clears cytotoxic reactive oxygen species (ROS) produced after ischemic stroke by converting to ascorbic acid (AA), thereby reducing neuronal and glial cell damage and stabilizing cerebral microvascular NO signaling to maintain perfusion in the ischemic area. It can be used in research on ischemic stroke.
- Crosses the blood-brain barrier
- Clears cytotoxic reactive oxygen species (ROS)
- Reduces neuronal and glial cell damage
- Stabilizes cerebral microvascular NO signaling
- Maintains perfusion in the ischemic area
- Used in research on ischemic stroke
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Selleck Chemical LLC Dittany Bark Extract E3035-5MG
Dittany Bark Extract is extracted from the bark of Dittany which is often used in treating inflammation bacterial and fungal infections reducing inflammation and digestive health
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Medchemexpress LLC IP7e | 500164-74-9 | 99.65% | 390.43 | 1 MG
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IP7e is a potent, brain-penetrant, and orally active Nurr1 activator with an EC50 value of 3.9 nM. It is intended for research use only and not for patient use.
- Potent Nurr1 activator.
- Brain-penetrant.
- Orally active.
- Reduces the incidence and severity of experimental autoimmune encephalomyelitis (EAE) in mice with preventive treatment.
- Attenuates inflammation and neurodegeneration in the spinal cords of EAE mice through an NF-kB pathway-dependent process.
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Medchemexpress LLC L-selectin/CD62L Cy 100ug | 100ug
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L-selectin/CD62L is a calcium-dependent lectin that aids cell adhesion by binding to neighboring glycoproteins It mediates lymphocyte adhesion to endothelial cells in peripheral lymph nodes causing leukocytes to tether and roll L-selectin/CD62L Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived L-selectin/CD62L protein expressed by HEK293 with C-His labeled tag
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eMolecules 117279-73-9 | ISRAPAFANT | J & W PharmLab LLC | MFCD00873428 | 489.080 | C28H29ClN4S | 96.000 | CC(C)Cc1ccc(CCc2cc3c(s2)-n2c(C)nnc2C(C)N=C3c2ccccc2Cl)cc1 | 10mg | 416222983
ISRAPAFANT | J & W PharmLab LLC | 117279-73-9 | MFCD00873428 | 489.080 | C28H29ClN4S | 96.000 | CC(C)Cc1ccc(CCc2cc3c(s2)-n2c(C)nnc2C(C)N=C3c2ccccc2Cl)cc1 | 10mg | 416222983
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Medchemexpress LLC T-5342126 | 956507-49-6 | 98.1% | 457.99 g·mol-1 | C25H32ClN3O3 | 10MG
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T-5342126 is a small-molecule toll-like receptor 4 (TLR4) antagonist for laboratory research. It inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 27.8 μM) and reduces LPS-induced IL-8, TNF-α, and IL-6 in isolated human whole blood; it also showed reduced ethanol intake and decreased microglial activation in an ethanol-dependence mouse model.
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Cayman Chemical C3a Receptor Agonist, Purity: ≥98%, CAS: 944997-60-8, 5 mg
A C3a receptor agonist
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Cayman Chemical Citrulline, Purity: ≥95%, CAS: 372-75-8, 10 g
A non-proteinogenic amino acid; produced by deimination of arginine through the post-translational modification citrullination
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AdipoGen Mycophenolic acid (500 mg)
Chemical. CAS: 24280-93-1. Formula: C17H20O6. MW: 320.3. Isolated from Penicillium brevi-compactum. Antibiotic. Shows antiviral, antifungal and antitumor properties. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform. Inhibits RNA and DNA synthesis. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor. Apoptosis and necrosis inducer. Novel type of inhibitor against RNA guanylyltransferases. Inhibits TNF-alpha-stimulated MAPK/NF-kappaB and ROS generation.
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Selleck Chemical LLC Galloflavin S9606-5MG
Galloflavin (NSC 107022) is a novel inhibitor of lactate dehydrogenasee (LDH) with Ki values of 5 46 M and 15 06 M for LDH-A and LDH-B respectively
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