Bioactive Small Molecules
Medchemexpress LLC Ro 61-8048 | 199666-03-0 | 99.8% | 421.45 | 100 MG
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, demonstrating an IC50 of 37 nM. This compound significantly increases extracellular kynurenic acid concentrations and has shown potential in reducing QUIN neo-formation and the severity of dystonia in experimental models.
- Orally active and selective kynurenine 3-hydroxylase inhibitor
- Increases extracellular kynurenic acid concentrations
- Reduces QUIN neo-formation
- Inhibits cerebral enzyme activity in vivo
- Reduces severity of dystonia in dtsz hamsters
- Appearance is a solid, off-white to light yellow in color
Cayman Chemical ANTIBODY DIeldrIn 25mg
An organochlorine insecticide; increases cell proliferation and the estrogen receptor transactivation gene response in MCF-7 cells (5 µM); inhibits R1881-induced androgen activity in CHO cells (20 µM); LD50 = 46 mg/kg in rats
Cayman Chemical ANTIBODY Acephate 50mg
An organophosphate insecticide active against a variety of insects; inhibits acetylcholinesterase in the house fly with a topical 24-hour LD50 value of 1.8 UG/g; induces reversible hyperglycemia after two and six hours and increases liver glycogen levels by 3.5-fold after six hours at 140 mg/kg
Medchemexpress LLC 4A3-Cit | 2768211-13-6 | C83H147N3O16S4 | 5 MG
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs). It facilitates endosomal escape by undergoing lipid fusion with endosomal membranes within the model.
- Enhances the efficiency of in vivo mRNA delivery through selective organ targeting (SORT)
Medchemexpress LLC Activated EG3 Tail | 1380600-06-5 | C43H47N3O10 | 50 MG
Activated EG3 Tail is used in the synthesis of exon jumping oligomer conjugates. It yields an oligomer conjugate that is complementary to a selected target site in the human dystrophin gene and can induce exon 51 skipping, making it suitable for muscular dystrophy research.
- Used in synthesis of exon jumping oligomer conjugates
- Yields an oligomer conjugate complementary to a selected target site in the human dystrophin gene
- Induces exon 51 skipping
- Applicable to the research of muscular dystrophy
Medchemexpress LLC Hesperidin | 520-26-3 | C28H34O15 | 50 MG
Hesperidin is a flavanone glycoside isolated from citrus fruits, known for its various biological properties. It decreases inflammatory mediators, exhibits significant antioxidant effects, and demonstrates antitumor and antiallergic activities.
- Decreases inflammatory mediators
- Exhibits significant antioxidant effects
- Shows antitumor activity
- Demonstrates antiallergic activities
- Induces potent cytotoxic effects in human osteosarcoma MG-63 cells
- Inhibits COX-2 and iNOS activity in LPS-activated RAW 264.7 cells
- Suppresses MG-63 tumor growth in mice
Medchemexpress LLC BTTES | 1334179-86-0 | C19H32N10O4S | 50 MG
BTTES is a tris(triazolylmethyl)amine-based ligand for Cu(I) without apparent toxicity. It improves the cycloaddition reaction rapidly in living systems.
- Tris(triazolylmethyl)amine-based ligand for Cu(I)
- No apparent toxicity
- Improves cycloaddition reaction rapidly in living systems
Cayman Chemical Theophylline 5mg
An analytical reference standard categorized as a caffeine metabolite; has been found as an adulterant in seized heroin samples; has been used as a marker of authentic human urine specimens; intended for research and forensic applications
Cayman Chemical Lanraplenb 5mg
A Syk inhibitor (IC50 = 6.2 nM); selective for Syk over a panel of 395 kinases but does inhibit JAK2 (IC50 = 120 nM); reduces anti-IgM- and anti-CD40-induced proliferation of isolated human B cells (EC50 = 108 nM); inhibits immune complex-induced production of TNF-α, IL-1β, and IL-6 in human macrophages (EC50s = 180, 90, and 700 nM, respectively); reduces proteinuria and increases survival in the NZBWF1 mouse model of SLE
Cayman Chemical HydroxocobalamIn 5mg
A biologically active form of Vitamin B12; increases the number of red blood cells by 2.5-fold over control in a mouse model of anemia when administered at a dose of 2 UG per day for 4 days; efficacious in animal models of cyanide poisoning
Cayman Chemical ANTIBODY C-178 5mg
A STING inhibitor; binds to Cys91 on STING to block its and prevents recruitment and phosphorylation of TBK1 in HEK293T cells; selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells from 0.01-1.25 µM; prevents increases in Ifnb1 expression induced by cyclic di-GMP, double-stranded DNA, and LPS in BMDMs at 0.5 µM
Medchemexpress LLC VU0424465 50mg | 1428630-85-6 | 50 MG
VU0424465 is a research small molecule characterized as a potent, partial positive allosteric modulator (PAM)-agonist of the metabotropic glutamate receptor 5 (mGlu5). It is supplied for laboratory research use only and is not intended for human consumption.
- High reported purity of 99.84%.
- Molecular weight 326.36 g/mol.
- Chemical formula C19H19FN2O2.
- Available in small pack sizes such as 50 mg for assay development.
- Suitable for pharmacology and medicinal chemistry research.
eMolecules 1051375-16-6 | DOLUTEGRAVIR | MFCD20488027 | 0.25g
Ambeed | 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene | 250mg | 525039931 | A133987 | 1089280-66-9 | MFCD11847613 | 205.570 | C7H5ClFNO3
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