Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,891 – 4,905 of 60,541 results

4,891

Cayman Chemical Hirsutide, Purity: ≥95%, CAS: 865368-30-5, 5 mg

A cyclotetrapeptide fungal metabolite; active against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia bacteria (MICs = 25, 13, 6, and 21 μg/cm3, respectively); active against C. albicans, M. audouinii, A. niger, and Ganoderma fungi (MICs = 13, 6, 25, and 6 μg/cm3, respectively)

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4,892

Cayman Chemical Sorafenib N-oxide, Purity: ≥98%, CAS: 583840-03-3, 5 mg

An active metabolite of sorafenib; inhibits FLT3-ITD (Kd = 70 nM); inhibits proliferation of MV4-11 AML cells expressing FLT3-ITD (IC50 = 25.8 nM); selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 µM); a linear-mixed inhibitor of CYP3A4 (Ki = 15 µM)

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4,893

Medchemexpress LLC 11,15-O-dimethyl-PGE2 | 211230-67-0 | 98.3% | 50 MG

ONO-AE 248 is a selective EP3 prostaglandin receptor agonist used in preclinical pharmacology and cardiovascular research. It is reported to reduce myocardial infarction size and is used as a research reagent.

Selective EP3 receptor agonist used in mechanism and pharmacology studies.
Reported cardioprotective activity in preclinical models.
High reported purity (98.3%) suitable for research applications.
Molecular formula C22H36O5; molecular weight 380.52 g/mol.
Soluble in DMSO; store protected from light at 4°C.

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4,894

Cayman Chemical Cyclosporin B, Purity: ≥98%, CAS: 63775-95-1, 5 mg

A fungal metabolite with diverse biological activities; inhibits the growth of T lymphoma cells in a concentration-dependent manner; inhibits P-gp activity in vitro (IC50 = 4.7 μM)

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4,895

Medchemexpress LLC TRPM8 antagonist 2 | 259674-19-6 | 98.1% | 398.50 | 25 MG

TRPM8 antagonist 2 is a potent and selective antagonist of TRPM8, with an IC50 of 0.2 nM. It is utilized in research for neuropathic pain syndromes. For research use only, this product is not intended for patient use.

Potent and selective TRPM8 antagonist with an IC50 of 0.2 nM.
Used in the research of neuropathic pain syndromes.
Potently inhibits menthol-induced increases in intracellular Ca2+ levels in Ca2+ fluorimetric assays in HEK293 cells stably expressing the rat isoform of TRPM8 channels (IC50, 40 nM).
Shows marked, dose-dependent antinociceptive activity in vivo.
Inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg.
Attenuates Oxaliplatin (OXP)-induced cold allodynia in mice.

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4,896

Medchemexpress LLC Trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f]triazin-7-yl]cyclohexanecarboxylic acid | 936890-98-1 | 100.0% | 406.44 g/mol | C21H22N6O3 | 1 ML

OSI-027 is a potent, ATP-competitive inhibitor of the mechanistic target of rapamycin (mTOR) that blocks both mTORC1 and mTORC2 and is used as a research tool in preclinical studies to probe mTOR signaling and anticancer activity. It is supplied as a 10 mM solution in DMSO (1 mL) and is also available as a solid form; molecular formula C21H22N6O3, molecular weight 406.44 g/mol, CAS 936890-98-1.

Potent dual mTORC1/mTORC2 inhibitor with low-nanomolar activity.
Supplied as a ready-to-use 10 mM solution in DMSO for convenient dosing.
Available as solid powder for custom formulation and storage.
High chemical purity suitable for research applications.
Stable when stored under recommended conditions for powder and solution.
Appropriate for preclinical oncology and signaling pathway studies.

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4,897

Medchemexpress LLC STING agonist-22 | 2408723-12-4 | C40H48N14O6 | 50 MG

STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. It acts as an adjuvant by activating STING to induce type I interferon (IFN-I) response and proinflammatory cytokine production. This product boosts protein vaccines for potent, broad, and long-term immune protection, and is suitable for research on SARS-CoV-2 variants and sarbecovirus diseases.

Activates STING, inducing type I interferon (IFN-I) and proinflammatory cytokine production.
Boosts protein vaccines as an adjuvant.
Provides potent, broad, and long-term immune protection.
Suitable for SARS-CoV-2 variants and sarbecovirus research.
Rapidly activates innate immune responses in THP-1 cells.
Activates innate immunity in mice with acceptable safety.
Stimulates humoral and cellular immune responses.

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4,898

Medchemexpress LLC CCR6 antagonist 1 | 588674-64-0 | C17H12F3NO2 | 5 MG

CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. It can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

Blocks CCL20-induced CD4+ T cell migration
Inhibits miniGi recruitment to CCR6 induced by CCL20
Shows anti-inflammatory effects in Zymosan-induced peritonitis mice
Alleviates TNBS-induced inflammatory responses in mice

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4,899

Cayman Chemical Apatinib, Purity: ≥98%, CAS: 811803-05-1, 25 mg

A selective VEGFR2 inhibitor (IC50 = 1 nM); inhibits the proliferation of HUVECs stimulated by FBS and prevents the growth of several established human tumor xenograft models

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4,900

Lkt Laboratories Busulfan, ≥98%, 10GR

Alkyl sulfonate; DNA alkylator. CAS: 55-98-1. Additional sizes available upon request. Ships from Saint Paul, MN.

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4,901

Medchemexpress LLC 2-(3-methoxypyridin-2-yl)-5-(trifluoromethoxy)-1H-benzo[d]imidazole | 1881276-00-1 | 98.9% | 50MG

2-(3-methoxypyridin-2-yl)-5-(trifluoromethoxy)-1H-benzo[d]imidazole | 1881276-00-1 | 98.9% | 50MG

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4,902

Medchemexpress LLC Purpurin | 81-54-9 | 256.21 | 1 ML

Purpurin is a natural anthraquinone compound derived from Rubia cordifolia L. This compound exhibits antidepressant-like effects and demonstrates antiproliferative activity against human HeLa cells.

Natural anthraquinone compound.
Exhibits antidepressant-like effects.
Shows antiproliferative activity against human HeLa cells.
For research use only.

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4,903

Cayman Chemical GS-7340, Purity: ≥98%, CAS: 379270-37-8, 100 mg

A prodrug from of tenofovir; reduces HIV-1 viral replication in MT-2 cells (EC50 = 5 nM)

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4,904

Apexbio Technology LLC BLU-554, 5mg CAS# 1707289-21-1

BLU-554 is an effective, highly selective, orally active FGFR4 inhibitor with IC50 of 5 nM. The IC50 range for FGFR1-3 is 624-2203 nM. In vitro, BLU-554 interacts with FGFR4 and has high potency and selectivity for FGFR4 inhibition; in vivo, BLU-554 is well tolerated in tumor models and induces tumor regression in liver cancer models. Other sizes are also available. Please inqury us for quote.

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4,905

Selleck Chemical LLC LJH685 5mg 1627710-50-2

LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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Medchemexpress LLC 11,15-O-dimethyl-PGE2 | 211230-67-0 | 98.3% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC TRPM8 antagonist 2 | 259674-19-6 | 98.1% | 398.50 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f]triazin-7-yl]cyclohexanecarboxylic acid | 936890-98-1 | 100.0% | 406.44 g/mol | C21H22N6O3 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC STING agonist-22 | 2408723-12-4 | C40H48N14O6 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CCR6 antagonist 1 | 588674-64-0 | C17H12F3NO2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-(3-methoxypyridin-2-yl)-5-(trifluoromethoxy)-1H-benzo[d]imidazole | 1881276-00-1 | 98.9% | 50MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Purpurin | 81-54-9 | 256.21 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More