Bioactive Small Molecules
Cayman Chemical ANTIBODY Ac-PAL-AMC 1mg
A fluorogenic substrate for the 20S proteasome; AMC is released upon enzymatic cleavage by the β1i/LMP2 subunit of the immunoproteasome and its fluorescence can be used to quantify enzyme activity; selective for the immunoproteasome over the constitutive proteasome; 351/430 nm, respectively
Selleck Chemical LLC LJH685 5mg 1627710-50-2
LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical ANTIBODY APHS 10mg
APHS is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and -2, with IC50 values of 17 and 0.8 µM for human recombinant COX-1 and -2, respectively.{6580} APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1. APHS acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition.{6580}
Medchemexpress LLC Dasatinib | 302962-49-8 | MFCD11046566 | ≥98.0% | 488.01 | C22H26ClN7O2S | 1 ML
Dasatinib is a potent, ATP-competitive small-molecule inhibitor of Bcr-Abl and Src family kinases used in research to probe kinase signaling, assess antitumor activity, and as a reference compound in biochemical and cell-based studies. It is typically handled as a solid for preparation of concentrated stock solutions or provided by suppliers as prepared solutions for experimental use.
- Potent dual Src/Bcr-Abl inhibition (IC50 <1.0 nM for Bcr-Abl, ~0.5 nM for Src).
- Suitable for biochemical assays and cell-based pathway studies.
- Includes guidance for preparing 1-10 mM stock solutions from solid material.
- Molecular weight 488.01; formula C22H26ClN7O2S; CAS 302962-49-8.
- For research use only; not for human or clinical use.
Medchemexpress LLC 4H-1-benzopyran-4-one, 6-[(1S,5R,6S)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3- | 85698-31-3 | 97.2% | 694.72 g/mol | C40H38O11 | 1MG
Sanggenon G is a cell-permeable small molecule inhibitor of X-linked inhibitor of apoptosis protein (XIAP) that binds the BIR3 domain and enhances caspase activation (reported binding affinity 34.26 μM). The compound is supplied as a solid (CAS 85698-31-3), has molecular formula C40H38O11 and molecular weight 694.72 g/mol, and is reported at 97.23% purity in the certificate of analysis.
- Inhibits XIAP by binding the BIR3 domain.
- Enhances caspase activation in cell-based assays.
- Characterized by molecular formula C40H38O11 and MW 694.72 g/mol.
- High reported purity suitable for research applications (97.23%).
- Available in small milligram quantities for laboratory use.
Cayman Chemical ANTIBODY MBQ-167 1mg
A dual inhibitor of Rac and Cdc42 (IC50s = 103 and 78 nM, respectively); reduces Rac and Cdc42 GTP-binding and GTPase activity and limits migration and mammosphere formation in MDA-MB-231 cells at 250 nM; reduces cell viability and induces apoptosis at 250 nM in lapatinib-resistant SK-BR-3 and MDA-MB-435 cells alone or with lapatinib; reduces growth rates, axial budding, and Cdc42 activity in S. cerevisiae at 200 µM; reduces tumor growth in an MDA-MB-435 mouse xenograft model at 1 or 10 mg/kg three times per week, i.p.
Medchemexpress LLC Chimmitecan | 25MG
Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin) a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560) is a potent inhibitor of topoisomerase I Chimmitecan exhibits anticancer activity[1]
STEMCELL Technologies ME0328, Size: 1 mg
ME0328 is a cell-permeable and selective inhibitor of poly(ADP-ribose) polymerase 3 (PARP-3; IC₅₀ = 0.89 µM; Lindgren et al.). PARP-3 is required for stabilization of the mitotic spindle and crucial for mitotic progression (Sharif-Askari et al.). CANCER RESEARCH· Enhances vinorelbine-induced microtubule destabilization, leading to cell cycle arrest and apoptosis in breast cancer cells (Sharif-Askari et al.).
Medchemexpress LLC 3,5-Difluoropicolinonitrile | 298709-29-2 | 140.09 | 10 G
3,5-Difluoropicolinonitrile is a high-purity chemical compound commonly appearing as a white to off-white solid. With a molecular weight of 140.09 and a purity of 99.8%, it is suitable for various laboratory research applications. This compound exhibits a melting point between 30-34°C and a boiling point of 187.8°C.
- Used as a biochemical reagent
- Suitable for laboratory research applications
- White to off-white solid appearance
- Molecular weight of 140.09
- Purity of 99.8% (GC)
- Melting point between 30-34°C
- Boiling point of 187.8°C
- Flash point of 90°C
![eMolecules 209984-57-6 | (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide | MFCD09832551 | 25mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502139324.JPG-250.jpg)
eMolecules 209984-57-6 | (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide | MFCD09832551 | 25mg
Ambeed | 5-Chloro-2-methyl-3H-imidazo[45-b]pyridine | 100mg | 525193710 | A350295 | 40851-92-1 | MFCD08692376 | 167.600 | C7H6ClN3
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eMolecules 1216720-69-2 | Medchem Express | SCH79797 (dihydrochloride) | 5mg | 495800569 | HY-14994 | MFCD04039788 | 444.4 | C23H27Cl2N5
Ambeed | (E)-2-Cyano-3-(34-dihydroxyphenyl)-N-phenylacrylamide | 10mg | 525177555 | A299892 | 133550-35-3 | MFCD00209863 | 280.283 | C16H12N2O3
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Apexbio Technology LLC GSK-3 Inhibitor IX (BIO) 667463-62-9 10mM (in 1mL DMSO)
GSK-3 Inhibitor IX (BIO CAS 667463-62-9) is a selective ATP-competitive reversible inhibitor targeting glycogen synthase kinase-3 (GSK-3) and isoforms showing potent inhibitory activity (IC50 for GSK-3 5 nM) GSK-3 a serine/threonine kinase modulates diverse cellular processes including insulin signaling neuronal health and cardiac function through Wnt/ -catenin pathways BIO promotes proliferation in mammalian cardiomyocytes by inducing cell cycle progression and -catenin signaling Additionally BIO sustains pluripotency in embryonic stem cells by activating canonical Wnt pathways and directly interacts with Wnt signaling components independent of AhR pathways
Sigma Aldrich Fine Chemicals Biosciences Cefuroxime Axetil Delta-3-Isomers United States Pharmacopeia (USP) Reference Standard | 123458-61-7 | 10MG
Cefuroxime Axetil Delta-3-Isomers United States Pharmacopeia (USP) Reference Standard | Mol Wt: 510.47 | 123458-61-7 | 10MG
Cayman Chemical 1 2 3-TrI-12 Z-HenIcosnoyl 5mg
A triacylglycerol containing heneicosenoic acid at the sn-1, sn-2, and sn-3 positions
![Medchemexpress LLC Cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone | 184025-18-1 | MFCD00951610 | >98.0% | 270.33 g/mol | C16H18N2O2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221125.png-250.jpg)
Medchemexpress LLC Cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone | 184025-18-1 | MFCD00951610 | >98.0% | 270.33 g/mol | C16H18N2O2 | 5 MG
Ciproxifan is a research reagent that functions as a selective histamine H3 receptor antagonist (synonym FUB-359). The listing corresponds to the free base (CAS 184025-18-1) and is provided as a high-purity compound for pharmacology and receptor-binding studies.
- Selective histamine H3 receptor antagonist for receptor pharmacology studies.
- Free base form with CAS 184025-18-1.
- High purity >98.0%.
- Small research pack: 5 MG.
- Chemical formula C16H18N2O2; molecular weight 270.33 g/mol.
- Intended for research use only; not for human or clinical use.