Bioactive Small Molecules
Cayman Chemical ANTIBODY TP-0903 5mg
An inhibitor of Axl (IC50 = 27 nM ); exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively; decreases the phosphorylation of Akt and Axl in GAS6-stimulated, serum-starved PSN-1 pancreatic cancer cells (EC50s = 305 and 222 nM, respectively); decreases cell viability (IC50 = 6 nM) and induces cell cycle arrest at the G2/M phase in PSN-1 cells at 30 nM; reduces the viability of CRC cell lines (IC50s = 4.5-123 nM); exhibits 69 and 44% tumor growth inhibition in an HCT116 mouse xenograft model and a K-Ras-mutant CRC PDX mouse model, respectively, at 40 mg/kg
Cayman Chemical ANTIBODY EtoposIde 100mg
An inhibitor of topoisomerase II (IC50 = 60.3 µM); inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and HUVEC cells (IC50 = 0.249 µM); reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model at 25 mg/kg, an effect enhanced by cyclosporin A; inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM).
Cayman Chemical ANTIBODY Tozadent 100mg
An adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for human and rhesus monkey receptors, respectively); increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson's disease induced by 6-OHDA at 30 mg/kg; reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson's disease at 150 mg/kg
Medchemexpress LLC N-(1-acetyl-2,3-dihydroindol-6-yl)-3-(3-cyanophenyl)-N-(1-(2-cyclopentylethyl)piperidin-4-yl)prop-2-enamide | 683746-68-1 | MFCD19690929 | 98.0% | 510.67 | C32H38N4O2 | 1 MG
This compound is a nonpeptidic antagonist of the neuropeptide Y Y2 receptor used as a research tool for pharmacology and signaling studies. It offers submicromolar potency at human and rodent receptors and high subtype selectivity.
- Nonpeptidic antagonist of the neuropeptide Y Y2 receptor.
- Submicromolar potency (pIC50 ≈ 7.0 human, 7.1 rat).
- Greater than 100-fold selectivity versus Y1, Y4, and Y5 receptors.
- Powder form, soluble in DMSO (≈5 mg/mL) with warming and sonication.
- Stable as powder at -20°C for long-term storage; in solvent store frozen.
- Molecular weight 510.67; molecular formula C32H38N4O2.
Cayman Chemical NCB 057643 5mg
A BET family protein inhibitor; inhibits binding of BRD2, BRD3, and BRD4 to an acetylated histone H4 peptide in vitro; decreases Myc levels in, and inhibits proliferation of, AML, DLBCL, and MM cells; reduces tumor growth in AML, DLBCL, and MM mouse xenograft models; reduces tumor growth when administered alone or in combination with docetaxel or MDV 3100 in a 22Rv1 CRPC mouse xenograft model
Medchemexpress LLC HY-N2166 20mg , Tomatine CAS:17406-45-0 Purity:>98%
HY-N2166 20mg Tomatine CAS: 17406-45-0 Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-D0214 50mg , Rose Bengal (sodium) CAS:632-69-9 Purity:>98%
HY-D0214 50mg Rose Bengal (sodium) CAS: 632-69-9 Rose Bengal sodium, a synthetic fluorescein derivative, and is a crimson-coloured dye with the principal component being 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein. Rose Bengal sodium has been widely used as an ophthalmic diagnostic agents, and can detect desiccated or damaged cells on the ocular surface. Rose Bengal sodium exhibits antiviral activities. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Ferrocene, 1,1'-bis(diphenylphosphino)- | 12150-46-8 | MFCD00001422 | 98.0% | 554.38 g·mol⁻¹ | C34H28FeP2 | 500g
DPPF (1 1 -Ferrocenediyl-bis(diphenylphosphine)) is a metal ligand DPPF enhances the stability of metal complexes DPPF can be used in the research of ovarian cancer[1][2][3]
Medchemexpress LLC Hexamethylphosphoramide | 680-31-9 | MFCD00008303 | 99.9% | 179.20 g/mol | C6H18N3OP | 500g
Hexamethylphosphoramide is an orally active polar aprotic solvent flame retardant additive and carcinogen Hexamethylphosphoramide undergoes cytochrome P-450-mediated N-demethylation to Formaldehyde Hexamethylphosphoramide induces DNA-protein crosslinks Hexamethylphosphoramide has been linked to nasal tumors (squamous cell carcinoma adenoid squamous cell carcinoma) squamous metaplasia rhinitis tracheitis and reversible and irreversible infertility[1][2][3][4][5][6][7]
Medchemexpress LLC HY-110153 5mg Medchemexpress, NS19504 CAS:327062-46-4 Purity:>98%
Medchemexpress, HY-110153 5mg NS19504 CAS:327062-46-4 NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY RBN-012759 10mg
A PARP14 inhibitor (IC50 = 0.003 µM); selective for PARP14 over PARP1-4, -5a, -5b, -6-12, -15, and -16 (IC50s = 1->100 µM); inhibits IFN-γ-induced PARP14 auto-MARylation in CFPAC-1 cells at 10 µM; induces expression of the genes encoding CCL13, CCL19, and CXCL11 in human kidney cancer tumor explants
Cayman Chemical 11a-Hydroxyprogesteron 1g
An 11-HSD inhibitor (IC50s = 0.63 and 0.4 µM for recombinant human 11β-HSD1 and 11β-HSD2, respectively) and a derivative of progesterone; reduces urinary sodium excretion in male adrenalectomized rats when administered at 10, 100, and 500 UG/animal in combination with corticosterone but not when administered alone; potentiates corticosterone-induced increases in urinary potassium in male adrenalectomized rats when administered at 10, 100, and 500 UG/animal but has no effect on urinary potassium excretion when administered alone; increases blood pressure in rats at 10 UG/hour, s.c., an effect that can be blocked by adrenalectomy or reduced by co-administration of RU-28318; has been used as a precursor in the synthesis of various steroids
Cayman Chemical ProstaglndIn E Synthase-1m 1ea
Peptide Sequence: human amino acids 59-75 (CRSDPDVERSLRAHRND){7229} · To be used in conjunction with Cayman’s Microsomal PGE Synthase-1 Polyclonal Antibody (Item No. 160140) to block protein-antibody complex formation during immunochemical analysis for microsomal PGE synthase.
Medchemexpress LLC GBT1118 | 1628799-51-8 | C19H20N2O4 | 50 MG
GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity, enhancing tolerance to severe hypoxia. It works by covalently and reversibly binding to the N-terminal valine of the hemoglobin α chain, allosterically increasing intracellular hemoglobin's affinity for oxygen. This action helps protect red blood cells from damage during severe hypoxia.
- Potent and orally active allosteric modifier of hemoglobin oxygen affinity
- Increases tolerance to severe hypoxia
- Binds covalently and reversibly to the hemoglobin α chain
- Increases intracellular hemoglobin affinity for oxygen
- Protects red blood cells from damage during severe hypoxia
- Improved oxygen delivery during hypoxia in animal studies
- Increased blood oxygen loading in the lungs in animal studies
- Decreased hypoxia in vital tissues and lowered lactate levels in animal studies
Medchemexpress LLC BSP16 | 2727249-47-8 | C16H18O5Se | 500 UG
BSP16 is a potent, orally active stimulator of interferon genes (STING) agonist. It can selectively stimulate the STING pathway and is used for cancer research.
- Selectively stimulates the STING pathway (EC50 values of 9.24 μM in ISG-THP1 cells, 5.71 μM in ISGRAW264.7 cells).
- Strongly activates STING signaling in human and mouse cells.
- Promising absorption, distribution, metabolism, excretion, and toxicity profiles.
- Well-tolerated and excellent pharmacokinetic profile in vivo.
- Induces tumor regression and durable antitumor immunity.
- Excellent antitumor efficacy in MC38 (colon carcinoma) syngeneic tumor model, achieving complete tumor regression.
- Induced tumor regression in all treated mice in a CT26 (colon carcinoma) tumor model.