Bioactive Small Molecules
Medchemexpress LLC Lalistat 2 | 1234569-09-5 | MFCD31544494 | 99.9% | 296.39 | C13H20N4O2S | 5 MG
Lalistat 2 is a small-molecule inhibitor of lysosomal acid lipase (LAL) used in biochemical and cellular research to probe lipid degradation pathways and to measure LAL activity in biological samples. It is supplied as a high-purity solid intended for in vitro assays and analytical applications.
- Potent LAL inhibition (IC50 152 nM) suitable for biochemical assays.
- High purity (≈99.9%) for reproducible results.
- Characterized molecular properties: formula C13H20N4O2S, molecular weight 296.39.
- Available in small solid quantities for research use.
- Stable when stored as powder: -20°C for 3 years, 4°C for 2 years.
- Short-term stability in solvent: -80°C for 6 months, -20°C for 1 month.
Cayman Chemical ANTIBODY AG-120 25mg
An orally available inhibitor of mutant IDH1 that may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells
Medchemexpress LLC Ac-IEPD-AMC | 216757-33-4 | 98.0% | 671.69 | 1 MG
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. It undergoes hydrolysis to release the fluorescent product 7-amino-4-methylcoumarin (AMC), which fluoresces under UV light irradiation and emits fluorescent signals.
- Measures protease activity
- Releases 7-amino-4-methylcoumarin (AMC) upon hydrolysis
- Emits fluorescent signals under UV light
- Functions as a fluorogenic substrate
- Categorized as a fluorescent dye, peptide, and enzyme substrate
Medchemexpress LLC Suc-AAPK-pNA | 108929-39-1 | 98.1% | 605.64 | 10 MG
Suc-AAPK-pNA is a chromogenic substrate used for determining serine/threonine kinase activity and enzyme kinetic parameters. This product is for research use only.
- Chromogenic substrate
- Used for determining serine/threonine kinase activity
- Used for determining enzyme kinetic parameters
- Intended for research use only
Cayman Chemical PDD00017273 5mg
A PARG inhibitor (IC50 = 26 nM in an enzyme assay); maintains persistence of nuclear PAR chains in HeLa cells in the presence of the DNA damaging agent MMS (IC50 = 37 nM); increases nuclear γH2AX intensity in MCF-7 cells in a concentration-dependent manner when used in combination with MMS; reduces clonogenic growth of ZR-75-1 and MDA-MB-436 cells but not HCC1937 cells (IC50s = 0.2, 0.8, and >10 μM, respectively)
Selleck Chemical LLC Triethylenediamine E2967-100MG
Triethylenediamine (1 4-Diazabicyclo[2 2 2]octane DABCO) is a caged tertiary diamine commonly used as a strong hindered amine base in chemical synthesis It is used in the synthesis of isoxazole derivatives via dehydration of primary nitro compounds in the presence of dipolarophiles It can also be employed as a complexing ligand and as a catalyst
Cayman Chemical ANTIBODY ABP 688 500ug
A non-competitive antagonist of mGluR5 (Ki = 3.5 nM in a radioligand binding assay using L(tk-) cell membranes expressing human receptors); binds at an allosteric binding site; selective for mGluR5 receptors over a panel of CNS G protein-coupled receptors, ion channels, and transporters at 10 μM; inhibits quisqualate-induced phosphoinositol accumulation in and glutamate-induced calcium release from L(tk-) cells expressing human mGluR5 (IC50s = 2.4 and 2.3 nM, respectively); radiolabeled forms have been used as PET tracers for in vivo imaging of mGluR5 receptors in rodents
Cayman Chemical CCT241533hydrochlorIde 5mg
A selective Chk2 inhibitor (IC50 = 3 nM); potentiates the cytotoxicity of the PARP inhibitors, rucaparib and olaparib
Selleck Chemical LLC Cyclocarya paliurus Extract E3574-5MG
Cyclocarya Paliurus Extract is extracted from Cyclocarya Paliurus which has anti-fibrotic activity
Selleck Chemical LLC Raf inhibitor 1 E2651-5MG
Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM 1 nM and 0 3 nM for B-Raf WT B-Raf V600E and C-Raf respectively
Cayman Chemical PentaNacetylchItopentaose 5mg
A pentameric chito-oligosaccharide involved in root nodulation; produced by NodC, a chito-oligosaccharide synthase, and serves as a substrate for NodL, an O-acetyltransferase; binds plant root lectins, an interaction that may be important in the promotion of cell division in the root cortex
Cayman Chemical ANTIBODY JaceosIdIn 1mg
A natural methylated trihydroxyflavone; has antioxidative actions on cells in culture; induces cell cycle arrest and apoptosis in cancer cells; blocks cell signaling related to inflammation
Medchemexpress LLC MRX-2843 | 1429882-07-4 | MFCD28502224 | 99.6% | 488.67 g/mol | C29H40N6O | 50 MG
MRX-2843 (UNC2371) is an orally active, ATP-competitive dual MERTK and FLT3 tyrosine kinase inhibitor used in preclinical cancer research. Reported enzymatic IC50 values are 1.3 nM for MERTK and 0.64 nM for FLT3. Supplied as a solid with high chemical purity, it is intended for in vitro and in vivo studies of kinase signaling and mechanisms of drug resistance.
- Potent dual inhibition of MERTK and FLT3 with low-nanomolar potency.
- Orally bioavailable type 1 kinase inhibitor suitable for preclinical models.
- High chemical purity supports reproducible research results.
- Supplied as a solid for flexible formulation and dosing.
- Useful for studying kinase signaling pathways and resistance mechanisms.
Cayman Chemical ANTIBODY Saclofen 5mg
A sulfonic analog of GABA that acts as a competitive antagonist of the GABAB receptor (IC50 = 7.8 µM)
Cayman Chemical ANTIBODY Exemestn 25mg
An irreversible inhibitor of aromatase (Ki = 26 nM); is selective for aromatase over 5α-reductase at 30 µM; decreases tumor proliferation in rats with DMBA-induced mammary tumors at 3-100 mg/kg per day, s.c.