Bioactive Small Molecules
Medchemexpress LLC ELN484228 10mg | 312-63-0 | 10 MG
ELN484228 is a small-molecule blocker of α-synuclein used in Parkinson's disease research. It is provided as a high-purity solid suitable for in vitro and in vivo pharmacology studies and is soluble in DMSO with compatible in vivo formulations.
- High purity (99.5%).
- Molecular weight 251.28 g/mol.
- Chemical formula C12H10FNO2S.
- Physical form solid powder.
- Solubility ≥50 mg/mL in DMSO; in vivo formulations documented.
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years).
- Available in small milligram pack sizes for research use.
Medchemexpress LLC Nociceptin (Orphanin FQ) | 170713-75-4 | 98.7% | 1809.04 | 10 MG
Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic.
- Target: Opioid receptor
- Pathway: GPCR/G protein; neuronal signaling
- Sequence: Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln
- Appearance: Solid, white to off-white
- Shipping: Room temperature in continental US (may vary elsewhere)
- Storage (powder): -80°C for 2 years; -20°C for 1 year (sealed, away from moisture)
- Storage (in solvent): -80°C for 6 months; -20°C for 1 month (sealed, away from moisture)
Apexbio Technology LLC Nilvadipine 75530-68-6 50mg
Nilvadipine (CAS 75530-68-6) is a dihydropyridine calcium channel antagonist that inhibits L-type voltage-gated calcium channels in vascular smooth muscle By reducing transmembrane calcium influx Nilvadipine induces vasodilation and lowers blood pressure making it widely studied in hypertension research In preclinical and clinical studies it has been employed to investigate vascular physiology neuroprotection and cardiovascular pharmacology supporting its use as a probe in the evaluation of calcium channel blockade and associated therapeutic strategies
Cayman Chemical ANTIBODY 15 R-HEDE 250ug
15(R)-HEDE is isolated by the chromatographic resolution of (±)15-HEDE. There are no reports of biological activity associated with 15(R)-HEDE in the literature.
Enzo Life Sciences Leukotriene A4 methyl ester (1mg). CAS: 73466-12-3
Unstable intermediate in the biosynthesis of LTB4 and LTC4. The naturally occuring free acid is a substrate for LTA4 hydrolase and LTC4 synthase and plays a central role in transcellular leukotrieneand lipoxin biosynthesis. Mobilizes Ca2+ in human neutrophils. Supplied as the methyl ester for greater stability. Alternative name: LTA4-ME. Formulation: Oil dissolved in 2% triethylamine/hexane. Purity: ≥95% (HPLC) (remainder 11-trans isomer). Long Term Storage: -80°C.
Selleck Chemical LLC 4-IBP
4-IBP is a selective 1 receptor agonist with a high level of affinity for the 1 receptor (Ki 1 7 nM) and a moderate affinity for the 2 receptor (Ki 25 2 nM)
AdipoGen Antibiotic PF 1052
Chemical. CAS 147317-15-5. Formula C26H39NO4. MW 429.6. Isolated from Phoma sp. Antibiotic. Antibacterial, antifungal and phytotoxic.
Selleck Chemical LLC STING inhibitor C-178
C-178 is a covalent inhibitor of STING covalently bind to Cys91
Medchemexpress LLC Efaroxan hydrochloride | 89197-00-2 | 99.8% | 5 MG
Efaroxan hydrochloride is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. It is a selective I1-Imidazoline receptor antagonist and can be used for the research of cardiovascular disease.
- Potent, selective, and orally active α2-adrenoceptor antagonist.
- Exhibits antidiabetic activity.
- Selective I1-Imidazoline receptor antagonist.
- Potentially useful for research in cardiovascular disease.
- Increases plasma insulin levels in rats without significantly affecting plasma glucose levels (In Vivo finding).
Selleck Chemical LLC D- S9349-25MG
Raffinose is a trisaccharide composed of galactose glucose and fructose
Medchemexpress LLC Ergolide | 54999-07-4 | 5 MG
Ergolide is an orally active dual inhibitor targeting NF-κB/p65 and NLRP3. It blocks the NF-κB signaling pathway, inhibits p65 nuclear translocation, and prevents inflammasome assembly by binding to the NACHT domain of NLRP3. This leads to reduced inflammatory mediators, cytokine production, and induction of cancer cell apoptosis, autophagy, and ROS generation. It also enhances the anti-tumor effect of vincristine and improves outcomes in models of acute lung injury and sepsis.
- Dual inhibitor for NF-κB/p65 and NLRP3.
- Inhibits inflammasome assembly.
- Reduces inflammation and promotes apoptosis in cancer cells.
- Enhances anti-tumor efficacy of vincristine.
- Beneficial in models of acute lung injury and sepsis.
- Research applications include uveal melanoma, neurodegenerative diseases, and acute lymphoblastic leukemia.
- Purity: 99.48%.
Medchemexpress LLC Khellin | 82-02-0 | 99.7% | 100 MG
Khellin is a furochromone isolated from *Ammi visnuga L.* It acts as an EGFR inhibitor with an IC50 of 0.15 μM. Khellin demonstrates anti-proliferative activity *in vitro* and possesses antispasmodic and coronary vasodilator effects.
- EGFR inhibitor with an IC50 of 0.15 μM.
- Exhibits anti-proliferative activity in MCF-7 cells and Hela cells.
- Possesses antispasmodic and coronary vasodilator effects.
- Inhibits Ca2+ influx pathways activated by noradrenaline and high K+.
Selleck Chemical LLC Liensinine S9411-1MG
Liensinine an important functional compound in lotus seeds has anti-cancer anti-fibrosis anti-proliferative antioxidant and anti-inflammatory activities
Selleck Chemical LLC Nodakenin S9260-1MG
Nodakenin (( )-Marmesinin) a coumarin compound acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84 7 M
Selleck Chemical LLC 3-n-Butylphathlide S9263-1MG
3-n-Butylphathlide initially isolated from the seeds of Apium graveolens Linn has shown significant neuroprotective effects