Bioactive Small Molecules
Apexbio Technology LLC Methimazole 60-56-0 25g
Methimazole is a small-molecule inhibitor targeting intercellular adhesion molecule-1 (ICAM-1) gene transcription It is designed to modulate ICAM-1 expression thereby regulating cell adhesion processes mediated by immunoglobulin superfamily members and integrins such as LFA-1 and Mac-1 Methimazole exerts its biological activity primarily through modulation of signal transducer and activator of transcription 1 (STAT1) In cell-based studies using thyroid cell models methimazole demonstrates inhibitory activity suppressing ICAM-1 mRNA expression induced by interferon-gamma (IFN- ) and H O Based on these pharmacological properties methimazole holds research potential in studying autoimmune thyroid conditions and as an agent to induce hypothyroidism in animal models for thyroid dysfunction research
Medchemexpress LLC HY-106406 5mg , Benzylacyclouridine CAS:82857-69-0 Purity:>98%
HY-106406 5mg Benzylacyclouridine CAS: 82857-69-0 Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-120139 5mg Medchemexpress, KMH-233 CAS:1941174-13-5 Purity:>98%
Medchemexpress, HY-120139 5mg KMH-233 CAS:1941174-13-5 KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC RALIMETINIB DIMESYLATE 10MG
Also available in 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ralimetinib dimesylate (LY2228820 dimesylate) is the dimesylate salt form of LY2228820 a tri-substituted imidazole derivative and orally available p38 mitogen-activated protein kinase (MAPK) inhibitor with potential anti-inflammatory and antineoplastic activities. purity: 99%
![Medchemexpress LLC 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-di | 2411321-29-2 | 99.4% | C20H24Cl2N4O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261495.png-250.jpg)
Medchemexpress LLC 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-di | 2411321-29-2 | 99.4% | C20H24Cl2N4O2 | 10MG
IACS-15414 is a small-molecule, orally bioavailable inhibitor of the SHP2 phosphatase with a reported IC50 of 122 nM, supplied for preclinical biochemical, cellular, and in vivo research. The compound has a molecular weight of 423.34, formula C20H24Cl2N4O2, and a reported purity of 99.39%.
- Potent SHP2 inhibitor (IC50 122 nM).
- Orally bioavailable and suitable for in vivo studies.
- High reported purity (99.39%).
- Soluble in DMSO (100 mg/mL) and compatible with published in vivo formulation protocols.
- Molecular weight 423.34 and formula C20H24Cl2N4O2.
- Recommended storage as powder at -20°C or 4°C for shorter term stability.
- Available in small research pack sizes for preclinical use.
Medchemexpress LLC Smurf1 ligand 1 | 99.3% | 386.41 | 25 MG
Smurf1 ligand 1 is a PROTAC target protein ligand that can be used for synthesizing SMART1 (HY-W998345). It is for research use only.
- Molecular weight: 386.41
- Formula: C21H18N6O2
- Appearance: Solid
- Color: Light brown to brown
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
![Medchemexpress LLC 1-Piperazineacetamide, 4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[6-[[3-[[[6-(dimethylamino)-3-pyridazinyl]amino]carbonyl]-6-(methylamino)-2-pyridinyl]amino]spiro[3.3]hept-2-yl]- | 3055472-38-0 | 98.1% | 884.04 |...](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000394292.png-250.jpg)
Medchemexpress LLC 1-Piperazineacetamide, 4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[6-[[3-[[[6-(dimethylamino)-3-pyridazinyl]amino]carbonyl]-6-(methylamino)-2-pyridinyl]amino]spiro[3.3]hept-2-yl]- | 3055472-38-0 | 98.1% | 884.04 |...
CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader that shows anti-proliferation. It is intended for research use only and is not sold to patients.
- Target: CDK4, CCND1
- Appearance: Solid, colorless to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder: -20°C for 3 years, 4°C for 2 years
- Storage: In solvent: -80°C for 6 months, -20°C for 1 month
Cayman Chemical Aurothioglucose (hydrate), Purity: ≥80%, 5 mg
A TrxR inhibitor (IC50 = 0.065 µM for the human placental enzyme); selective for TrxR over glutathione reductase and GPX (IC50s = >100 and 80 µM, respectively); inhibits IL-1β-induced production of IL-6 and IL-8 in isolated human rheumatoid synovial fibroblasts at 100 µM; reduces HIV-1 replication induced by TNF-α in OM10.1 cells latently infected with HIV-1 at 10 and 25 µM; improves survival in a mouse model of ARDS induced by LPS and hyperoxia at 25 mg/kg; induces obesity and increases food intake and blood glucose levels in genetically diabetic KK mice
Cayman Chemical CBGP, Purity: ≥98%, CAS: 55824-15-2, 5 mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Medchemexpress LLC CD163 Human HEK293 50ug | 50ug
The CD163 protein is an acute-phase regulatory receptor that clears hemoglobin/haptoglobin complexes through endocytosis by macrophages protecting tissues from potential oxidative damage In addition to iron uptake CD163 also exhibits calcium- and pH-dependent binding preferences with higher affinity for the hemoglobin/haptoglobin complex of the HP 1F phenotype CD163 Protein Human (HEK293 His-Avi) is the recombinant human-derived CD163 protein expressed by HEK293 with C-His C-Avi labeled tag
![Medchemexpress LLC L-valine, N-[4-(4-propylcyclohexyl)benzoyl]- | 1241902-40-8 | 99.8% | 345.48 g/mol | C21H31NO3 | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236616.png-250.jpg)
Medchemexpress LLC L-valine, N-[4-(4-propylcyclohexyl)benzoyl]- | 1241902-40-8 | 99.8% | 345.48 g/mol | C21H31NO3 | 100MG
GNE-0439 is a small-molecule Nav1.7-selective sodium channel inhibitor used in research to study voltage-gated sodium channel pharmacology. It contains a carboxylic acid moiety, exhibits Nav1.7 IC50 = 0.34 μM with reduced activity at Nav1.5 (IC50 = 38.3 μM), and has molecular formula C21H31NO3 (MW 345.48 g/mol).
- Nav1.7-selective sodium channel inhibitor with Nav1.7 IC50 0.34 μM.
- Shows reduced activity on Nav1.5 (IC50 38.3 μM), indicating selectivity.
- Molecular formula C21H31NO3 and molecular weight 345.48 g/mol.
- High purity (99.8%) suitable for research applications.
- Soluble in DMSO (~130 mg/mL) and compatible with common in vivo vehicles.
- Solid is stable at 4°C; solutions are recommended at -80°C for long-term storage.
- Offered in solid and solution formats for flexible dosing and formulation.
Medchemexpress LLC DL-homocysteine thiolactone hydrochloride | 6038-19-3 | MFCD00012724 | 100.0% | 153.63 g/mol | C4H8ClNOS | 250 G
DL-homocysteine thiolactone hydrochloride is a cyclic amino acid derivative supplied for laboratory research. It exhibits root-growth inhibitory activity and is provided in solid and solution forms with high reported purity for use as a biochemical reagent and synthetic intermediate.
- CAS number 6038-19-3.
- Molecular formula C4H8ClNOS.
- Molecular weight 153.63 g/mol.
- Purity 99.97%.
- Available as solids (10 g-1,000 g) and 10 mM solution in DMSO.
- Typical use: biochemical research and synthetic intermediate.
Apexbio Technology LLC GNE-9605 1536200-31-3 10mM (in 1mL DMSO)
GNE-9605 (CAS 1536200-31-3) is a selective brain-penetrant inhibitor of leucine-rich repeat kinase 2 (LRRK2) a kinase implicated in the pathogenesis of Parkinson s disease and Crohn s disease GNE-9605 exhibits high potency against LRRK2 with a reported Ki of 2 0 nM and IC50 of 18 7 19 nM In pharmacokinetic studies GNE-9605 demonstrates excellent metabolic stability in human hepatocytes and high oral bioavailability (90%) in rats In BAC transgenic mice expressing the G2019S LRRK2 mutation GNE-9605 potently inhibits LRRK2 Ser1292 autophosphorylation in a dose-dependent manner This compound supports preclinical investigations of LRRK2 signaling and its role in neurodegenerative disease
Medchemexpress LLC 3-(2,3-dihydrobenzofuran-7-yl)acrylic acid | 630424-80-5 | MFCD20658882 | 100mg
3-(2 3-Dihydrobenzofuran-7-yl)acrylic acid is a drug impurity