Bioactive Small Molecules
Cayman Chemical ANTIBODY Moperon 5mg
A dopamine D2, D3, and D4 receptor antagonist (Kis = 0.7, 14, and 27 nM, respectively, in NIH3T3 cells expressing the human receptors); inhibits E. electricus AChE (Ki = 120 µM); is a histamine H1 receptor inverse agonist (IC50 = 794 nM); intraocular administration induces ocular hypotension in normotensive rabbits at 0.5% w/v
Cayman Chemical ANTIBODY DB07268 1mg
A potent inhibitor of JNK1 (IC50 = 9 nM); binds to the ATP site of JNK1; selective for JNK1 over P38, ERK2, AKT1, CHK1, and PAK4 among others
Medchemexpress LLC Transcription Factor EB Antibody (YA3266) | 50 UL
The Transcription Factor EB Antibody (YA3266) is a rabbit-derived antibody designed to react with human proteins. It is supplied as a liquid formulation suitable for various laboratory applications.
- Host: Rabbit
- Reactivity: Human
- Clonality: YA3266
- Molecular weight: Predicted band size 53 kDa; Observed band size 65-70 kDa
- Concentration: 0.3 mg/mL
- Non-conjugated
- Applications include WB, IHC-F, IHC-P, ICC/IF, and IP
- Formulated in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Store at -20°C for 1 year
- Avoid repeated freeze / thaw cycles
- Ships with blue ice
Cayman Chemical ANTIBODY RIbavIrIn 500mg
An antiviral nucleoside analog; metabolized to an active triphosphate form that induces viral chain termination and inhibits viral polymerases; reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 UG/ml); reduces replication of SARS-CoV-2 in Vero cells (EC50 = 109.5 µM); aerosol administration reduces mortality in a mouse model of influenza A infection at 30 mg/kg
Cayman Chemical CUMYL-CB-MeGACLOn 5mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical ANTIBODY EMD 638683 5mg
An inhibitor of SGK1; inhibits SGK1 by 85% at 1 µM; >27-fold selective for SGK1 over a panel of 11 kinases, but does inhibit SGK2, SGK3, PRK2, and MSK1 by >50% at 1 µM; inhibits phosphorylation of the SGK1 target NDRG1 in HeLa cells (IC50 = 3.35 µM); increases radiation-induced apoptosis of Caco-2 colon carcinoma cells at 50 µM; dietary administration reduces the number of tumors in a mouse model of chemical carcinogenesis; prevents fructose and saline consumption-induced increases in systolic blood pressure in mice; decreases body weight, fasting blood glucose and HbA1c levels, and food intake in db/db diabetic mice; reduces angiotensin II-induced collagen deposition and cardiac fibrosis in mice
Cayman Chemical ANTIBODY BPR1J-097 50mg
An FLT3 inhibitor (IC50 = 11 nM); selective for FLT3 over FLT1, KDR, Aurora A, and Aurora B kinases (IC50s = 211, 129, 340, and 876 nM, respectively); inhibits FLT3 activity and phosphorylation of STAT5 in MV4-11 AML cells containing the FLT3 activating mutant FLT3-ITD (IC50s = 10 and 1 nM, respectively); inhibits the growth of FLT3-dependent MOLM-13 and MV4-11 AML cells (GI50s = 21 and 46 nM, respectively); inhibits tumor growth in a MOLM-13 mouse xenograft model at 25 mg/kg
Medchemexpress LLC Nrp1 antagonist 1 | 2569598-01-0 | MFCD35061294 | 99.7% | C22H22N6OS2 | 10MG
NRP1 antagonist 1 is a small-molecule neuropilin-1 (NRP1) antagonist supplied for research use. It inhibits NRP1 with an IC50 of 19.1 μM, has molecular formula C22H22N6OS2 and molecular weight 450.58, and is provided as high-purity material suitable for cancer-related biological studies.
- Demonstrated NRP1 inhibition (IC50 19.1 μM).
- High purity for reliable biochemical and cell-based assays (99.7%).
- Available in multiple pack sizes and in DMSO solution formats.
- Suitable as a small-molecule tool for cancer research applications.
- Accompanied by datasheet, COA, and SDS for quality and handling information.
Medchemexpress LLC GNE-781 | 1936422-33-1 | 98.5% | 525.59 | 10 MG
GNE-781 is an orally active, highly potent, and selective CBP inhibitor with an IC50 of 0.94 nM in a TR-FRET assay. It also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. It has demonstrated antitumor activity in an MOLM-16 AML xenograft model. GNE-781 is a potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) and is highly selective for CBP/P300.
- Orally active
- Highly potent and selective CBP inhibitor
- Inhibits BRET and BRD4(1)
- Displays antitumor activity in an MOLM-16 AML xenograft model
- Reduces FOXP3 (forkhead box P3) transcript levels
- Exquisitely selective for CBP/P300
- Decreases Foxp3 transcript levels in a dose-dependent manner in vivo
- Suppresses MYC in vivo
Medchemexpress LLC 1,2-diheptanoyl-sn-glycero-3-phosphocholine | 39036-04-9 | 99.5% | 50 MG
1,2-diheptanoyl-sn-glycero-3-phosphocholine is a synthetic short-chain phosphatidylcholine used as a lipid detergent and model membrane component in biochemical and biophysical research. It has defined molecular properties and is supplied at high purity for laboratory applications.
- Short-chain phosphatidylcholine suitable for micelle formation and membrane mimetics.
- High purity for analytical and biophysical assays.
- Defined molecular weight and formula for accurate stoichiometry.
- Available in multiple small pack sizes for lab-scale experiments.
- Compatible with common organic solvents for lipid dispersion preparation.
STEMCELL Technologies (-)-Blebbistatin, Size: 5 mg
(-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases (Kovács et al.; Straight et al.). It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC₅₀ = 80 μM) (Limouze et al.).MAINTENANCE AND SELF-RENEWAL· Increases human pluripotent stem cell (hPSC) survival and cloning efficiency after dissociation to single cells, downstream of ROCK inhibition (Chen et al.; Ohgushi et al.; Walker et al.; Xu et al.). · Enables hPSC to be cultured on microcarriers without surface coating (Chen et al.)· Inhibits differentiation of human mesenchymal stem cells (McBeath et al.; Engler et al.).
Abcam NU 7026, DNA-PK inhibitor, 5MG
MW 281.3 Da, Purity >99%. Novel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC₅₀ = 0.23 μM). Increases G₂/M arrest and inhibits double-strand break repair.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC H 33258 trihydrochloride E2910-5MG
bisBenzimide H 33258 Trihydrochloride(Hoechst 33258 trihydrochloride H 33258 trihydrochloride) is a marker dye in Hoechst series Hoechst is A live nuclear marker dye It binds to the grooves in the DNA double strand which tends to be A/ T-rich DNA strand Although it binds to all nucleic acids the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore Hoechst dye can be used for living cell labeling The fluorescence intensity of Hoechst dye increases with the increase of pH of solution It exhibits anti-tumor activity IC50 of 51 31 4 56 M in HeLa cells
Medchemexpress LLC Avasopasem manganese | 435327-40-5 | 96.1% | 483.38 | 100 MG
Avasopasem manganese is a potent superoxide dismutase mimetic. It rapidly and specifically converts superoxide radicals to hydrogen peroxide, thereby arresting the initiation of damaging cascades.
- Potent superoxide dismutase mimetic
- Rapidly and specifically converts superoxide radicals to hydrogen peroxide
- Arrests the initiation of damaging cascades
- Used for research of severe oral mucositis and cancer
- Intended to interrupt severe oral mucositis pathogenesis
- Reduces duration, incidence, and severity of radiation-induced oral mucositis