Bioactive Small Molecules
Cayman Chemical ANTIBODY CAY10762 10mg
An inhibitor of MAGL (IC50 = 34.1 nM); reduces hydrogen peroxide-induced LDH release from Neuro2a cells at 1 µM; increases levels of 2-AG in mouse brain at 10 mg/kg
Cayman Chemical GSK2837808A 1mg
A potent inhibitor of LDHA and LDHB (IC50s = 2.6 and 0.43 nM, for human recombinant LDHA and LDHB, respectively); inhibits lactate production in Snu398 hepatocellular carcinoma cells in which LDHB expression is undetectable (EC50 = 400 nM); reduces glucose consumption in Snu398 but not HepG2 cells; 30 cancer cell lines show differential sensitivities to GSK2837808A (EC50s from 400 nM to 30 µM); potency does not correlate with LDHA, LDHB, or total LDH expression levels
Cayman Chemical 3 5-DIcaffeoylquInIc AcId 5mg
A natural phenolic compound that has antioxidant, anti-inflammatory, and antiviral biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 71.8 μM); inhibits superoxide production in fMLF- and cytochalasin B-activated human neutrophils (IC50 = 1.92 μM); inhibits HIV-1 integrase 3’-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively); inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml); protects mice from LPS-induced acute lung injury and decreases neutrophil count in BALF at 25 mg/kg
Cayman Chemical ANTIBODY WT161 25mg
A potent inhibitor of HDAC6 (IC50 = 0.40 nM); selective for HDAC6 over HDAC3 (IC50 = 51.61 nM); induces α-tubulin acetylation, an HDAC6-dependent process, with minimal effect on global lysine acetylation; inhibits growth of patient-derived multiple myeloma cell lines (IC50s = 1.5-4.7 μM); enhances cytotoxicity of bortezomib and carfilzomib against patient-derived multiple myeloma cells; decreases tumor size in a human MM.1S multiple myeloma mouse xenograft model when administered in combination with bortezomib at doses of 50 and 0.5 mg/kg, respectively
Apexbio Technology LLC Spermine tetrahydrochloride 306-67-2 100mg
Spermine tetrahydrochloride (CAS 306-67-2) is an endogenous polyamine involved in cellular metabolism and homeostasis It modulates enzyme activities and signaling pathways particularly influencing cell cycle progression and nucleic acid stability In biomedical research Spermine tetrahydrochloride is commonly employed to investigate mechanisms regulating cell proliferation DNA and RNA interactions and the cellular response in oncological models Its ability to interfere with these processes makes it a valuable reagent for studies on cancer biology and the regulation of cell growth
Cayman Chemical ANTIBODY CP 724 714 10mg
A selective inhibitor of HER2/ErbB2 (IC50 = 10 nM); inhibits the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 (IC50s = 0.25 and 0.95 μM, respectively) and demonstrates antitumor activity in various human tumor xenograft models
Cayman Chemical ANTIBODY D-Xylulose 1mg
A ketopentose that is converted from xylitol in the glucoronate-xylulose pathway
Cayman Chemical ANTIBODY MPC-3100 5mg
An inhibitor of Hsp90 (IC50 = 0.14 µM); inhibits proliferation of a variety of cancer cell lines, including colon, prostate, ovarian, gastric, and breast cancer cells (IC50s = 0.2-0.55 µM), as well as MV4-11 leukemia, A549 NSCLC, NCI H69 SCLC, and multidrug-resistant NCI/ADR-RES cells (IC50s = 0.25, 0.77, 0.15, and 4.3 µM, respectively); induces degradation of Akt and HER2 (IC50s = 0.1-0.5 µM) and a compensatory Hsp70 response in NCI N87, HCT116, and DU145 cell lysates; induces Hsp70 expression in the liver and tumor tissue and reduces tumor growth in an NCI N87 mouse xenograft model at 50 and 75 mg/kg and tumor regression at 125 and 200 mg/kg
Medchemexpress LLC Rostafuroxin | 156722-18-8 | 99.0% | 50 MG
Rostafuroxin is a small-molecule ATP1A1 (Na+/K+-ATPase) antagonist supplied as a research-grade analytical standard for laboratory use. It is used to study Na+/K+-ATPase modulation, hypertension mechanisms, and related signaling pathways.
- High purity suitable for analytical and research applications.
- CAS 156722-18-8 and well-defined molecular identity.
- Molecular formula C23H34O4 and molecular weight 374.5 g/mol.
- Soluble in DMSO; typical handling for small-molecule standards.
- Pack size commonly supplied as 50 MG.
Medchemexpress LLC HY-101086 100mg Medchemexpress, Acetylcholine (iodide) CAS:2260-50-6 Purity:>98%
Medchemexpress, HY-101086 100mg Acetylcholine (iodide) CAS:2260-50-6 Acetylcholine iodide is a common neurotransmitter found in the central and peripheral nerve system [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY GSK5182 10mg
An ERRγ inverse agonist (IC50 = 77 nM in a reporter assay); selectively binds to ERRγ over ERα, ERRα, and ERRβ (IC50s = 0.11, 2, >10, and >10 µM, respectively); enhances radioiodine uptake and NIS membrane localization in BHT-101 and CAL-62 anaplastic thyroid cancer cells; inhibits osteoclastogenesis induced by RANKL and M-CSF in primary mouse BMDMs and induces apoptosis in osteoclasts at 10 µM; inhibits ACEA-induced fibrinogen secretion in AML12 hepatocytes at 10 µM; decreases blood glucose levels in a pyruvate tolerance test in a mouse model of high-fat diet-induced obesity at 40 mg/kg
TARGETMOL CHEMICALS INC EPIDERMAL GROWTH FACTOR 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Epidermal Growth Factor binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. It is approved for the treatment of diabetic foot ulcers. purity: 100%
Medchemexpress LLC Methyl 2-((6S)-4-(4-chlorophenyl)-2-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino) | 2243076-67-5 | 98.9% | 50 MG
ZXH-3-26 is a proteolysis targeting chimera (PROTAC) that links a Cereblon ligand to a BRD4 ligand to induce selective BRD4 degradation, with a reported DC50/5h of approximately 5 nM. It is supplied as a 50 mg vial at high purity for use in chemical biology and targeted protein degradation research.
- Selective BRD4 degradation with DC50/5h ≈ 5 nM.
- Minimal degradation of BRD2 and BRD3 at tested concentrations.
- Molecular formula C38H37ClN8O7S and molecular weight 785.27.
- Purity 98.9% and supplied as a 50 mg quantity.
- Includes SMILES for cheminformatics and structure confirmation.
Medchemexpress LLC 4-hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione | 39674-97-0 | MFCD00616487 | 98.4% | 241.24 g/mol | C14H11NO3 | 50 MG
BVT948 is a small-molecule research compound that functions as a protein tyrosine phosphatase (PTP) inhibitor. It is used in biochemical and cell-based studies to probe PTP-mediated signaling and has reported activity against several cytochrome P450 isoforms and the lysine methyltransferase SETD8.
- Noncompetitive, irreversible PTP inhibition with a cell-permeable profile.
- Also inhibits multiple cytochrome P450 isoforms and SETD8.
- High purity (98.4%) suitable for biochemical and cellular assays.
- Solid, pink to red appearance; available as solid material and as DMSO solution.
- Recommended sealed storage to preserve stability in solid or solution form.