Bioactive Small Molecules
Cayman Chemical ANTIBODY CeapIn-A7 50mg
An ATF6α inhibitor (IC50 = 0.59 µM in a reporter assay); selective for ATF6α over ATF6β at 18.9 µM; sensitizes U2OS cells to thapsigargin; chondrocyte-conditioned media from primary human chondrocytes pre-incubated with ceapin-A7 (0.5 µM) prior to stimulation with TNF-α, IFN-γ, or IL-17 has a reduced ability to induce tube formation in HUVECs; inhibits viral RNA production in Vero cells infected with SARS-CoV-2 at 15 µM
Medchemexpress LLC HY-125017 5mg Medchemexpress, Bozitinib CAS:1440964-89-5 Purity:>98%
Medchemexpress, HY-125017 5mg Bozitinib CAS:1440964-89-5 Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
AdipoGen 56-FITC
Chemical. CAS 27072-45-3. Formula C21H11NO5S. MW 389.38. Synthetic. Fluorescein isothiocyanate FITC remains one of the most popular fluorescent labeling reagents. Oligonucleotide conjugates of FITC are frequently employed as hybridization probes. Peptide conjugates of FITC and other fluorescent isothiocyanates are susceptible to Edman degradation, making them useful for high-sensitivity amino acid sequencing, FITC-labeled amino acidd and peptides have been separated by capillary electrophoresis with a detection limit of fewer than 1000 molecules. FITC has also been used to detect proteins in gels and on nitrocellulose membranes and is a selective inhibitor of several membrane ATPases.
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 25mg, CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies
![Medchemexpress LLC 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-(benzisoxazol-6-ylmethoxy)benzenepropanoic acid | 530141-72-1 | 99.6% | 25MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231631.png-250.jpg)
Medchemexpress LLC 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-(benzisoxazol-6-ylmethoxy)benzenepropanoic acid | 530141-72-1 | 99.6% | 25MG
5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-(benzisoxazol-6-ylmethoxy)benzenepropanoic acid | 530141-72-1 | 99.6% | 25MG
Medchemexpress LLC U-0521 | 5466-89-7 | 98.7% | 25 MG
U-0521 is a catechol-O-methyltransferase (COMT) inhibitor used for research into Parkinson's disease. It inhibits RBC COMT activity in vitro (IC50 6 x 10^-6 M) and produces dose-dependent COMT inhibition in vivo (50% at 90 mg/kg; 90% at 250 mg/kg).
- Inhibits catechol-O-methyltransferase (COMT).
- Shows potential for Parkinson's disease research.
- Demonstrates in vitro activity with an IC50 of 6 x 10^-6 M against RBC COMT.
- Produces dose-dependent in vivo COMT inhibition (50% at 90 mg/kg; 90% at 250 mg/kg in male Sprague-Dawley rats).
- High purity (98.67%) and solid, white to off-white appearance.
- Soluble in DMSO (100 mg/mL) with recommended in vivo formulation protocols and storage conditions.
Medchemexpress LLC Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate | 1919050-87-5 | 99.2% | 371.33 g/mol | C17H17F4N3O2 | 10MM 1ML
RL648_81 is a small-molecule activator of KCNQ2/3 potassium channels supplied as a 10 mM solution in DMSO for in vitro research. It shifts the V1/2 of KCNQ2/3 channels toward hyperpolarized potentials and shows an EC50 of about 190 nM. Molecular weight is 371.33 g·mol⁻1, chemical formula C17H17F4N3O2, and analytical purity 99.2%.
Cayman Chemical ANTIBODY PIrozadIl 250mg
A lipid-lowering agent; reduces serum and aortic cholesterol levels, serum LDL levels, and atherosclerotic lesion areas on the aorta and coronary lumen in a rabbit model of atherosclerosis induced by a high-cholesterol diet at 50 mg/kg per day
Medchemexpress LLC 3-methoxyisoquinoline-1-carboxylic acid | 374917-64-3 | MFCD01845410 | 99.6% | 203.20 | C11H9NO3 | 1 G
3-Methoxyisoquinoline-1-carboxylic acid is an organic chemical intermediate used in medicinal chemistry for the synthesis of active compounds. It is supplied for research use only and is not intended for human therapeutic or diagnostic use.
- Use as a drug intermediate for synthesis
- Molecular formula: C11H9NO3
- Molecular weight: 203.20 g/mol
- Purity: 99.6% (HPLC)
- Storage: store at room temperature; in solvent, store at -80°C for long-term preservation
Medchemexpress LLC HY-119932 1mg Medchemexpress, PROTAC FAK degrader 1 CAS:2301916-69-6 Purity:>98%
Medchemexpress, HY-119932 1mg PROTAC FAK degrader 1 CAS:2301916-69-6 PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC GNE-8505 25mg | 1620573-48-9 | 25 MG
GNE-8505 is an orally available inhibitor of dual leucine zipper kinase (DLK) supplied as a high-purity research chemical for biochemical and cellular studies targeting DLK/MAP3K signaling.
- High purity: 99.86%.
- Molecular weight: 419.44 g/mol.
- Chemical formula: C21H24F3N5O.
- Available as solid (1 mg, 5 mg, 10 mg, 25 mg) and as a 10 mM solution in DMSO.
- Soluble in DMSO for solution formats.
Selleck Chemical LLC AMTB hydrochloride E4673-1G
AMTB hydrochloride is a blocker of the transient receptor potential melastatin 8 (TRPM8) ion channel It reduces the activation of TRPM8 channels induced by icilin as assessed through a Ca2 influx assay with a pIC50 of 6 23 It is used as a tool to evaluate the role of this channel in bladder rhythmic contraction
Cayman Chemical ANTIBODY ArbutIn 25g
A glycosylated hydroquinone with diverse biological activities; inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM); inhibits AAPH-induced hemolysis in sheep erythrocytes at 50 μM; inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts at >125 μM; prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum in an LPS-induced rat model of acute lung injury at 50 mg/kg
Selleck Chemical LLC TNO155-2MG
TNO155, 2MG, CAS# 1801765-04-7 *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Phenanthrene | 85-01-8 | 99.8% | 1 ML
Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) commonly used to detect or assess PAH pollution in the environment. It induces inflammation, oxidative stress, and apoptosis.
- Reduces mitochondrial membrane potential.
- Induces oxidative stress and inflammation.
- Can cause liver damage and promote hepatocyte apoptosis.
- Supplied as a 10 mM solution in DMSO.