Bioactive Small Molecules
Medchemexpress LLC HY-18669 5mg Medchemexpress, ML346 CAS:100872-83-1 Purity:>98%
Medchemexpress, HY-18669 5mg ML346 CAS:100872-83-1 ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Insulin-like growth factor-binding protein 7 (IGFBP-7), mouse, Fc-tagged | 95.0% | 2 UG
Recombinant mouse insulin-like growth factor-binding protein 7 (IGFBP-7) fused to a C-terminal human Fc tag, expressed in HEK293 cells. Supplied as a purified protein for research applications investigating IGF availability, cell adhesion, or prostacyclin production.
- Recombinant mouse IGFBP-7 protein
- Expressed in HEK293 cells
- C-terminal human Fc tag for stability and detection
- Approximate molecular weight 55-70 kDa (glycosylated)
- Purity ~95%
- Intended for in vitro research applications
Medchemexpress LLC 2H-1-benzopyran-3-carboxylic acid, 2-oxo- | 531-81-7 | MFCD00006852 | 99.9% | 190.15 | C10H6O4 | 5 G
Coumarin-3-carboxylic acid (2-Oxochromene-3-carboxylic acid) is a coumarin derivative used as an intermediate for coumarin synthesis and as a fluorescent probe for hydroxyl radicals in biochemical research. It is supplied as a white to off-white solid with high analytical purity and DMSO solubility.
- High purity: 99.93%.
- White to off-white solid form.
- Soluble in DMSO: 100 mg/mL; ultrasonic assistance recommended.
- Useful as a fluorescent probe for hydroxyl radicals (•OH).
- Suitable as a synthetic intermediate for coumarin derivatives.
- Reported to form lanthanide complexes with antiproliferative activity.
Cayman Chemical GNE-3511, Purity: ≥98%, CAS: 1496581-76-0, 25 mg
A selective and highly potent inhibitor of DLK; also inhibits phosphorylated JNK (IC50 = 30 nM); selective over other MAP kinases, JNKs, and MLKs; protects primary neurons in an in vitro axon degeneration assay (IC50 = 107 nM); decreases p-c-Jun expression in a mouse MPTP model of Parkinson’s disease
Medchemexpress LLC HY-103352 100mg , L-006235 CAS:294623-49-7 Purity:>98%
HY-103352 100mg L-006235 CAS: 294623-49-7 L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC EF24 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. EF24 (35-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9 and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK/ERK signaling pathway. purity: 98%
Medchemexpress LLC BMS-986121 | 313671-26-0 | 100.0% | C15H9Cl2N3O2S | 25 MG
BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor, developed from patent WO2014107344. It is built on a novel chemical scaffold, representing a new chemotype for μ receptor PAMs.
- Potent positive allosteric modulator of the μ opioid receptor.
- Augments β-arrestin-recruitment response.
- Increases inhibition of adenylyl cyclase activity.
- Enhances the potency of endomorphin-I and leu-enkephalin in cAMP-accumulation assays.
Medchemexpress LLC 10,11-Dehydrocurvularin | 21178-57-4 | 1 MG
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. It acts as a strong activator of the heat shock response, inhibits the TGF-β signalling pathway, and demonstrates anti-tumorous activity.
- Purity of 99.59%
- Molecular weight of 290.31
- Chemical formula: C16H18O5
- Appears as a solid, white to light yellow
- Originates from microorganisms, Aspergillus terreus
- Soluble in DMSO
Cayman Chemical Tetracaine, Purity: ≥98%, CAS: 94-24-6, 1 mg
An analytical reference standard categorized as an anesthetic; has been found as an adulterant in products marketed as male sexual function enhancers; intended for research and forensic applications
Medchemexpress LLC Sulfinpyrazone (Standard) | 57-96-5 | 96.8% | 25 MG
Sulfinpyrazone (Standard) is the analytical standard of Sulfinpyrazone, intended for research and analytical applications. It is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis, also possessing antithrombotic and platelet inhibitory effects. As an analytical standard, it is commonly used in qualitative, quantitative, and methodological research experiments.
- Functions as an analytical standard
- Suitable for research and analytical applications
- Acts as an orally active and potent uricosuric agent
- Used for chronic and intermittent gouty arthritis
- Possesses antithrombotic and platelet inhibitory effects
- Utilized in experiments like HPLC, GC, and MS
Cayman Chemical Vilanterol, Purity: ≥98%, CAS: 503068-34-6, 5 mg
A β2-AR agonist; selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively); inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips; inhibits histamine-induced bronchospasms in guinea pigs when administered via nebulization (EC50 = 30 µM)
Selleck Chemical LLC Dulaglutide P1115-100MG
Dulaglutide is a GLP-1 receptor agonist approved for the management of hyper glycaemia in people with type 2 diabetes in many countries P1115 is its biologically active polypeptide part the sequence is His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser- Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Gly-Gly
Medchemexpress LLC YW2065 | 2131223-85-1 | 99.9% | C20H15BrN4O | 10MG
YW2065 is a small-molecule Axin-1 stabilizer that inhibits Wnt/β-catenin signaling and activates AMPK, demonstrating anti-colorectal cancer activity in cellular assays. It is intended for research use and has defined purity, formula, and storage recommendations.
Medchemexpress LLC MicroRNA-21-IN-1 | 2848720-31-8 | 98.0% | 548.65 g/mol | C30H37FN6O3 | 5 MG
microRNA-21-IN-1 is a small-molecule inhibitor of microRNA-21 (miR-21) for cellular research. It exhibits antiproliferative activity in cancer cell lines and modulates downstream functional targets of miR-21, supporting studies of miR-21 biology and anticancer mechanisms.
- Efficient miR-21 inhibition in cellular assays.
- Antiproliferative activity in HeLa and HCT-116 cells (IC50 5.5 μM and 2.8 μM).
- Promotes apoptosis in HeLa cells.
- Modulates downstream targets PTEN, EGR1, and SLIT2.
- High purity solid suitable for research use (98.0%).
- Available in small research pack sizes for dosing studies.
Medchemexpress LLC 3-amino-4-phenoxy-5-sulfamoylbenzoic acid | 28328-54-3 | MFCD00988316 | 100mg
Bumetanide impurity 1 is an impurity of Bumetanide (HY-17468)