Bioactive Small Molecules
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Filtered Search Results
Medchemexpress LLC SDU-071 | 3036109-10-8 | 98.8% | 435.52 | 5 MG
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SDU-071 | 3036109-10-8 | 98.8% | 435.52 | 5 MG
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World Precision Instrument GSNO S-nitrosoglutatione-GSNO-100
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GSNO has been identified in vivo as a potential storage and transport vehicle for NO in the body. GSNO has been used in clinical trials to treat a form of preeclampsia and to prevent platelet aggregation. It also has considerable potential as NO donor in medicine.
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Medchemexpress LLC TRIOCTYL TRIMELLITAT 5MG | 5MG
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TRIOCTYL TRIMELLITAT 5MG | 5MG
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Medchemexpress LLC ZXH-3-26 | 2243076-67-5 | 98.9% | 100MG
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ZXH-3-26 | 2243076-67-5 | 98.9% | 100MG
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Selleck Chemical LLC 3-Amino-9-ethylcarbazole E2703-100MG
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3-Amino-9-ethylcarbazole (AEC) is a chemical compound commonly used as a chromogenic substrate in immunohistochemistry specifically for visualizing sections stained with HRP-conjugated secondary antibodies
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Selleck Chemical LLC CDDO-Im S9723-5MG
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CDDO-Im (RTA-403) is an activator of nuclear factor erythroid 2 related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR) CDDO-Im binds to PPAR and PPAR with Ki of 232 nM and 344 nM respectively CDDO-Im inhibits inflammatory response and tumor growth in vivo
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Cayman Chemical LIcoglIflozInmIxed Isomers 5mg
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A mixture of licogliflozin isomers
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Cayman Chemical ANTIBODY 2-D08 10mg
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A synthetic flavone inhibitor of sumoylation; inhibits sumoylation completely in microfluidic electrophoretic mobility shift and kinetic assays at a concentration of 30 µM; inhibits sumoylation in breast cancer cell lines; disrupts the transfer of SUMO to the substrate; neuroprotective against Aβ aggregation and toxicity; has antioxidant properties
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Cayman Chemical DmyoInosItol1 3 4trIphosp 1mg
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A member of the InsP family of small, soluble second messengers; inhibits Ins(3,4,5,6)P4 kinase activity to increase the cellular level of Ins(3,4,5,6)P4
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Cayman Chemical Gelsevrne 5mg
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An oxindole alkaloid with anti-inflammatory activity; binds to STING (Kd = 27.6 µM) and prevents 2'3'-cGAMP-induced Sting dimerization in RAW 264.7 cells at 5 µM; inhibits 2'3'-cGAMP-, poly(dA:dT) dsDNA-, or IFN-stimulatory DNA-induced increases in the levels of mRNA encoding CXCL10 and IL-6 in THP-1 monocytes and RAW 264.7 cells at 10 µM; inhibits 2'3'-cGAMP-induced increases in the levels of Sting and phosphorylated IRF3, p65, and TBK1 in RAW 264.7 cells at 5 µM; increases animal survival time, reduces lung injury and total protein levels in BALF, and decreases serum levels of ALT, AST, creatinine, IL-6, TNF-α, and BUN levels in a mouse model of sepsis induced by CLP at 20 mg/kg
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Cayman Chemical ANTIBODY GX-674 5mg
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A state-dependent inhibitor of Nav1.7; selectively inhibits Nav1.7 in HEK293 cells in a patch-clamp assay at -40 mV over -120 mV (IC50s = 0.1 and 240 nM, respectively); selective for Nav1.7 over Nav1.1, Nav1.3-1.5, and Nav1.8 but does inhibit Nav1.2 and, to a lesser extent, Nav1.6
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Medchemexpress LLC DHFR-IN-4 | 2820126-49-4 | C18H21N5O2S | 1 MG
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DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. It also exhibits inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively, demonstrating remarkable broad-spectrum cytotoxic potency against cancer cells.
- Potent dihydrofolate reductase (DHFR) inhibitor (IC50 = 123 nM)
- Inhibitory activity against EGFR (IC50 = 246 nM) and HER2 (IC50 = 357 nM)
- Remarkable broad-spectrum cytotoxic potency against cancer cells
- Exhibits antiproliferative activity against HepG2, MCF-7, HCT-116, PC3, and HeLa cell lines
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Medchemexpress LLC Jnj DGAT2-A | 1962931-71-0 | MFCD30182366 | 98.3% | 523.38 g·mol⁻1 | C24H16BrFN4O2S | 5 MG
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JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor used for research into triglyceride synthesis and lipid metabolism. It exhibits potent biochemical activity and cellular efficacy, and is supplied at analytical purity suitable for in vitro studies.
- Selective DGAT2 inhibition with an IC50 of 0.14 μM.
- Reduces triglyceride species in HepG2 cells with IC50 values ~0.66-0.99 μM.
- High purity (≈98.3%) appropriate for biochemical assays.
- Available in research-scale sizes, including 5 mg.
- Stable when stored dry at 4°C; recommended low-temperature storage for solutions.
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Cayman Chemical DamInozIde-d4 5mg
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An internal standard for the quantification of daminozide by GC- or LC-MS
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Cayman Chemical ANTIBODY Lu AE58054 25mg
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A 5-HT6 receptor antagonist (Ki = 0.83 nM); selective for 5-HT6 over other 5-HT receptor subtypes (Kis = 250 to >10,000 nM) and 70 other targets but does bind to α1A- and α1B-ARs (Kis = 21 and 22 nM, respectively); reverses phencyclidine-induced deficits in novel object recognition memory in rats at 5-20 mg/kg; has an additive effect on the decreased number of slips and falls made by rats in a dual-lesion model of Parkinson’s disease motor disruption when administered in combination with rivastigmine
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