Bioactive Small Molecules
Cayman Chemical ANTIBODY CP 544 326 25mg
A potent EP2 receptor agonist (IC50s = 10 and 15 nM for human and rat EP2, respectively); selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM); increases cAMP in HEK293 cells expressing human EP2 (EC50 = 2.8 nM)
TARGETMOL CHEMICALS INC BMH-21 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BMH-21 a small molecule DNA intercalator binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX. purity: 99%
Medchemexpress LLC 2-Pyridineacetamide, N-[(3-fluorophenyl)methyl]-5-[4-(4-morpholinyl)phenyl]- | 897016-26-1 | 99.1% | 405.46 | 25 MG
This compound functions as an inhibitor for Src-kinase and tubulin polymerization. It exhibits favorable oral bioavailability and efficiently permeates the blood-brain barrier in mice. The compound also demonstrates anti-tumor capabilities and prompts apoptosis in Glioblastoma (GBM) cells.
- Inhibits Src-kinase
- Acts as a tubulin polymerization inhibitor
- Possesses good oral bioavailability
- Readily crosses the blood-brain barrier in mice
- Shows anti-tumor activity
- Induces apoptosis of Glioblastoma cells
- Reduces autophosphorylation of Src in cells
- Promotes cell cycle arrest at the G2/M phase
- Inhibits the in vitro assembly of tubulin polymers
- Significantly delays progression of orthotopic brain tumors
- Produces long-term survival in a murine model
- Demonstrates appreciable brain penetration when dosed orally
![Medchemexpress LLC 1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine | 489416-12-8 | 99.9% | 371.47 g/mol | C24H25N3O | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245473.png-250.jpg)
Medchemexpress LLC 1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine | 489416-12-8 | 99.9% | 371.47 g/mol | C24H25N3O | 100 MG
ST-193 is a small-molecule research compound that functions as a potent, broad-spectrum arenavirus inhibitor. It shows low-nanomolar activity against multiple pathogenic arenaviruses and is used for in vitro and preclinical research. CAS 489416-12-8.
- Potent broad-spectrum arenavirus inhibitor with low-nanomolar IC50 values.
- Soluble in DMSO (100 mg/mL) and in selected formulation vehicles at ≥ 2.5 mg/mL.
- Molecular formula C24H25N3O; molecular weight 371.47 g/mol.
- Storage: powder -20°C (stable 3 years) or 4°C (stable 2 years); in solvent -80°C (2 years).
- Intended for in vitro and preclinical research targeting arenavirus infection pathways.
Cayman Chemical ANTIBODY14-HDHA 250ug
(±)14-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA.{7483,7484,7492} 14(S)-HDHA is also produced by salmon gills upon stimulation with calcium ionophore.{7514} 14(S)-HDHA is an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3.6, and 5.3 µM, respectively.{7484,7481} (±)14-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
Cayman Chemical ANTIBODY DPQ 5mg
A potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM; about 10-fold less potent against PARP2
AdipoGen Ibudilast (50 mg)
Chemical. CAS: 50847-11-5. Formula: C14H18N2O. MW: 230.3. Ibudilast is a non-selective PDE (phosphodiesterase) inhibitor found to have anti-inflammatory activity primarily targeting the peripheral immune system and in the CNS via attenuation of glial cells.Ibudilast is an inhibitor of phosphodiesterase 4 (PDE4; IC50s = 54, 65, 239 and 166nM for PDE4A-D, respectively), PDE3A, PDE3B and PDE5A (IC50s = 1600, 2700 and 3510nM, respectively) and has been shown to act as a toll-like receptor 4 (TLR4) antagonist. Ibudilast is an allosteric inhibitor of macrophage inhibitory factor (MIF), which regulates the immune response known to drive inflammation and the cytokine storm. Overexpression of MIF is linked to multiple disease, including ARDS, asthma, rheumatoid arthritis, lupus and multiple sclerosis. Blocking the effects of MIF can protect patients with COVID-19 from developing ARDS.
Cayman Chemical ANTIBODY VU0661013 1mg
An Mcl-1 inhibitor (Ki = 97 pM); selective for Mcl-1 over Bcl-xL and Bcl-2 (Kis = >40 and 0.73 µM, respectively); inhibits cell growth in a panel of AML cell lines (GI50s = 0.16-7.62 µM); decreases blood, bone marrow and spleen leukemic burden, reduces splenomegaly, and increases survival in a MV4-11 disseminated AML mouse xenograft model at 75 mg/kg; selectively inhibits GPX4 (IC50 = 8.4 µM) over GPX1, GPX2, GR, and TrxR1
Medchemexpress LLC 5'-O-TBDMS-dA | 51549-30-5 | 99.9% | 365.50 | 1 ML
5'-O-TBDMS-dA is a modified nucleoside that can be used to synthesize DNA or RNA. It is for research use only.
- Modified nucleoside
- Used to synthesize DNA or RNA
- Purity: 99.9%
- Molecular weight: 365.50
- Appearance: White to off-white solid
- Classified as oligonucleotide and nucleoside analog
TARGETMOL CHEMICALS INC VELUFENACIN 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Velufenacin is an antagonist of muscarinic receptor[1]. purity: 98%
Cayman Chemical 22 S 23 S-HomobrasInolIde 5mg
A synthetic brassinosteroid; increases the rooting percentage in P. abies cuttings when applied topically at 60 ppm
Cayman Chemical DIquafosolsodIum salt 5mg
A P2Y2 and P2Y4 receptor agonist (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays); selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM); induces the release of mucin-like glycoproteins from rabbit conjunctival goblet cells, as well as reduces desiccation-induced corneal damage in a rabbit model of dry eye disease at 0.1 and 1% w/v
Apexbio Technology LLC PHA-848125 802539-81-7 10mg
PHA-848125 (CAS 802539-81-7) is a small-molecule ATP-competitive inhibitor primarily targeting Cdk2/cyclin A with an IC50 of 45 nM It also inhibits other cyclin-dependent kinases including Cdk7/cyclin H Cdk4/cyclin D1 Cdk5/p35 Cdk2/cyclin E and Cdk1/cyclin B but with lower potency (IC50 values ranging from 0 15 to 0 398 M) In cellular studies PHA-848125 reduces hyperphosphorylated forms of retinoblastoma protein (pRb) and increases its hypophosphorylated state reflecting inhibition of CDK-mediated cell cycle progression In vivo oral administration suppresses A2780 ovarian tumor xenograft growth by up to 91% PHA-848125 is utilized in cell cycle and oncology research
Cayman Chemical ElaIdIc AcId-d17 5mg
An internal standard for the quantification of elaidic acid by GC- or LC-MS
Abcam Sal003, eIF2alpha phophatase inhibitor, 10MG
MW 463.21 g/mol, Purity >99%. Cell-permeable eIF2α phophatase inhibitor. Decreases cyclin D1 levels in vitro. Anticancer agent. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement