Bioactive Small Molecules
Cayman Chemical ANTIBODY NSC 617145 1mg
An inhibitor of WRN helicase (IC50 = 230 nM); inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner; inhibits growth of HeLa cells via formation of DSBs and induction of apoptosis in a WRN helicase-dependent manner
Enzo Life Sciences DAPT (25mg). CAS: 208255-80-5
Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling. Alternative name: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine tert-butyl ester, gamma-Secretase inhibitor IX. Purity: ≥98% (HPLC). Solubility: Soluble in 100% ethanol, DMSO (20mg/ml) or dichloromethane. Long Term Storage: -20°C.
Cayman Chemical ANTIBODY BIthIonl 50g
An anthelmintic agent; a NAPE-PLD antagonist (IC50 = 2.1 µM); selective for NAPE-PLD over LPL and CA (IC50s = 46 and 178 µM, respectively); inhibits efferocytosis in primary mouse BMDMs at 10 µM; inhibits TNF-α-induced NF-κB transcriptional activity in a reporter assay using HEK293 cells (IC50 = 11.2 µM); inhibits caspase-3 activity by 90% in a cell-free assay at 33 µM and prevents diphtheria toxin-, cholera toxin-, or P. aeruginosa exotoxin A-induced death in RAW 264.7 macrophages at the same concentration; inhibits the replication of Zika virus in primary human astrocytes and Vero E6 cells (EC50s = 5.5 and 6.3 µM, respectively); decreases the number of G. salaris helminths in G. salaris-infected O. mykiss without inducing toxicity at 12.5 or 20 mg/L
Cayman Chemical Ethyl 4-nPPhydrochlorIde 5mg
An analytical reference standard that is structurally similar to known opioids; intended for research and forensic applications
Abcam GBR 13069 dihydrochloride, dopamine reuptake inhibitor, 10MG
MW 521.48 g/mol, Purity >99%. Potent dopamine reuptake inhibitor (IC₅₀ = 40 nM). Inhibits noradrenaline reuptake (IC₅₀ = 800 nM). Stimulates locomotor activity and shows central effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam Tetrahydrouridine (aqueous solution), cytidine deaminase inhibitor, 25MG
MW 248.23 Da, Purity >80%. Competitive cytidine deaminase inhibitor (IC₅₀= 152 μM). Modulates antiproliferative effects. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Apexbio Technology LLC ML 281 100mg
ML 281 (CAS 1404437-62-2) is a small-molecule inhibitor targeting serine/threonine kinase STK33 It is designed to block the phosphorylation activity of STK33 thereby interfering with downstream signaling pathways regulated by STK33-mediated phosphorylation events ML 281 exerts its biological activity primarily through selective inhibition of STK33 kinase activity In biochemical assays ML 281 demonstrates potent inhibitory effects with an IC50 value of approximately 14 nM against STK33 Based on these pharmacological properties ML 281 holds research potential in investigating the biological role of STK33 in tumor cell survival cellular proliferation and oncogenic signal transduction pathways
Cayman Chemical SphngomyelIn Synthase 2hum
Source: Recombinant N-terminal mouse IgG1 Fc-tagged human SMS2 expressed in HEK293 cells • Amino acids: 1-79 • MW: 35.7 kDa
Cayman Chemical Asenapn 5mg
An atypical antipsychotic; binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as various 5-HT receptors (Kis = 0.03-3.98 nM); inhibits DOI, apomorphine, or clonidine-induced neuron firing in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively); increases mPFC, NAc, and lateral striatum extracellular dopamine and suppresses the conditioned avoidance response in rats from 0.05-0.2 mg/kg, s.c.; prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats at 0.075 mg/kg
Cayman Chemical ANTIBODY CCT251236 1mg
An inhibitor of Hsf1-mediated transcription; binds to Pirin (Ki = 28 nM) and inhibits Hsf1-mediated induction of Hsp27 in U2OS cells (IC50 = 19 nM); inhibits growth of SKOV3 ovarian carcinoma cells (GI50 = 1.1 nM); reduces tumor volume in an SKOV3 mouse xenograft model at 20 mg/kg
Cayman Chemical ANTIBODY MRK-740 5mg
A PRDM9 inhibitor (IC50 = 80 nM); inhibits PRDM9-dependent trimethylation of ectopic histone H3K4 (IC50 = 0.8 µM) and endogenous H3K4 in HEK293 cells in a concentration-dependent manner; induces meiotic defects in mouse spermatocytes
Medchemexpress LLC Golvatinib | 928037-13-2 | 99.9% | 25 MG
Golvatinib (E-7050) is a potent dual inhibitor of both c-Met and VEGFR2 kinases with IC50s of 14 and 16 nM, respectively. It effectively inhibits phosphorylation of c-Met and VEGFR-2, repressing the growth of c-Met amplified tumor cells and endothelial cells.
- Inhibits phosphorylation of c-Met and VEGFR-2
- Represses growth of c-Met amplified tumor cells and endothelial cells
- Circumvents resistance to EGFR-TKIs by blocking the Met/Gab1/PI3K/Akt pathway
- Prevents emergence of gefitinib-resistant cells
- Shows inhibition of c-Met and VEGFR-2 phosphorylation in tumors
- Strongly inhibits tumor growth and angiogenesis in xenograft models
QA Bio Inc Neuraminidase Au - Alpha (2-3,6,8,9) - 200 µls
Alpha (2-3,6,8,9) Neuraminidase Au cleaves all cleaves all non-reducing terminal sialic acid residues from complex carbohydrates and glycoproteins. The relative cleavage rates for different linkages are: α(2-6) > α(2-3) > α(2-8), α(2-9). • In addition, the enzyme will cleave branched sialic acids (linked to an internal residue). This property makes it unique among neuraminidases. High concentrations of enzymes and prolonged incubation times may be required for cleaving branched residues. To cleave only non- reducing terminal α(2-3) unbranched sialic acid residues, use Neuraminidase SP, part number E-S007. • Source: recombinant from Arthrobacter ureafaciens in E. Coli. • EC 3.2.1.18 • Contents: Neuraminidase in 20 mM Tris-HCl, 25 mM NaCl, pH 7.5 / 5x Reaction Buffer 250 mM sodium phosphate, pH 6.0 • Specific Activity >135 U/mg • Activity>5 U/ml • Molecular weight 70,000 daltons • pH range 4.5-7, optimum 6.0
TARGETMOL CHEMICALS INC MCN-A 343 10MG
Also available in 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental models of ulcerative colitis. purity: 99%
TARGETMOL CHEMICALS INC ISO-RJW100 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. (Iso)-RJW100 is a potent liver receptor homolog 1 (LRH-1 NR5A2) and steroidogenic factor-1 (SF-1 NR5A1) agonist with pEC 50 s of 6.4 and 7.2 respectively. purity: 99%