Bioactive Small Molecules
STEMCELL Technologies PP1, Size: 10 mg
Inhibit LCK, FYN, HCK, and SRC with PP1 (Hanke et al. J Biol Chem, 1996). This reversible inhibitor of the SRC family of tyrosine kinases regulates a variety of cellular processes, such as apoptosis and migration. It is used in cancer research to induce apoptosis in non-small cell lung cancer cell lines (Zhang et al. Am J Pathol, 2007) and block TGF-β-mediated migration of primary non-small cell lung carcinoma cells and pancreatic ductal adenocarcinoma cell lines (Bartscht et al. Cancer Chemother Pharmacol, 2012). PP1 is also used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in the absence of reprogramming factor SOX2 (Staerk et al. Angew Chem Int Ed Engl, 2011; Ma et al. Circ Res, 2013). PP1 is supplied as a crystalline solid with ≥98% purity; Molecular weight 281.4 g/mol; CAS Number 172889-26-8. Visit STEMCELL.com for more information and related products.
Cayman Chemical FerrIchromeIron-free 5mg
A hydroxamate siderophore produced by various fungi that facilitates iron chelation and uptake; can be utilized as a heterologous siderophore by bacteria including P. aeruginosa and V. parahaemolyticus; inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor at 0.8 μM; inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner
Cayman Chemical ANTIBODY RY785 5mg
A selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 µM)
Medchemexpress LLC Nestoron | 7759-35-5 | 99.8% | 1 ML
Nestoron (ST-1435) is a 19-norprogesterone derivative exhibiting high affinity and selectivity for progesterone receptors. This highly selective and potent progestogen has potential application as a hormonal contraceptive.
- Exhibits high affinity and selectivity for progesterone receptors.
- Acts as a highly selective and potent progestogen.
- Can be used as a hormonal contraceptive.
- Molecular weight: 370.48.
- Chemical formula: C23H30O4.
- Appears as a white to off-white solid.
- Soluble in DMSO at 33.33 mg/mL (89.96 mM).
Medchemexpress LLC HY-N0268 5mg Medchemexpress, Irisflorentin CAS:41743-73-1 Purity:>98%
Medchemexpress, HY-N0268 5mg Irisflorentin CAS:41743-73-1 Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC MrgprX2 antagonist-8 | 2768216-96-0 | 97.0% | 540.99 | 50 MG
MrgprX2 antagonist-8 (example 5b) is a MrgprX2 antagonist that can be used for the research of inflammatory disorders.
- Has an activity of 100-500 nM in the hexokinase assay using LAD2 mast cells.
- Has an activity of less than 100 nM in CHO cells.
- Has a molecular weight of 540.99.
- Appears as a white to off-white solid.
Cayman Chemical ANTIBODY ARN810 1mg
A SERD; binds to ERα and ERβ (IC50s = 6.1 and 8.8 nM, respectively); induces degradation of ERα in MCF-7 cells (EC50 = 0.7 nM); inhibits 17β-estradiol-induced ERα transcriptional activity in a reporter assay and reduces MCF-7 breast cancer cell viability (IC50 = 2 nM); inhibits 17β-estradiol-induced uterine weight gain in rats at 1 mg/kg; reduces tumor volume in tamoxifen-sensitive and -resistant MCF-7 mouse xenograft models
Cayman Chemical Glycolthocholc ACD 3sulfa 5mg
A metabolite of glycolithocholic acid; induces cholestasis and increases biliary cholesterol secretion in rats at 240 µmol/kg; serum levels are increased in patients with cirrhosis, hepatitis, or cholestasis
Cayman Chemical ANTIBODY-Menthol 5g
A racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthol
eMolecules 1258-84-0 | Medchem Express | Pristimerin | 5mg | 446275639 | HY-N1937 | MFCD01711331 | 464.646 | C30H40O4
Ambeed | Methyl 7-fluoro-1H-indole-6-carboxylate | 100mg | 602851960 | A380278 | 1427366-38-8 | MFCD23706323 | 193.177 | C10H8FNO2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Cayman Chemical BetulnIc ACD propargyl Ste 5mg
An alkyne derivative of betulinic acid; has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives
Cayman Chemical ANTIBODY ADB-P7AICA 1mg
An analytical reference standard categorized as a synthetic cannabinoid; intended for research and forensic applications
![Medchemexpress LLC Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]- | 2123489-30-3 | 99.7% | 462.40 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437562-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]- | 2123489-30-3 | 99.7% | 462.40 | 1 ML
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.
- Allosteric With-No-Lysine (WNK) kinase inhibitor.
- IC50 of 4 nM for WNK1.
- IC50<2 μM in the cellular OSR1 phosphorylation assay.
- Reasonable aqueous solubility.
- ATP noncompetitive inhibition.
- Excellent selectivity with only a few significant off-target kinase inhibitions (BTK and feline encephalitis virus-related (FER) kinase) when tested against a panel of 440 human kinases at 10 μM concentration.
- Predicted allosteric binding mode outside the highly conserved ATP-pocket.
Medchemexpress LLC HY-B0307 500mg Medchemexpress, Idoxuridine CAS:54-42-2 Purity:>98%
Medchemexpress, HY-B0307 500mg Idoxuridine CAS:54-42-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC GNE-495 E4722-25MG
GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3 7 nM It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model