Bioactive Small Molecules
Cayman Chemical BIBX1382, Purity: ≥98%, CAS: 196612-93-8, 10 mg
An EGFR inhibitor (IC50 = 3 nM); selective for EGFR over HER2 (IC50 = 3,400 nM), as well as IGF-1R, β-InsRK, c-Met, c-Src, and VEGFR2 (IC50s = >10 µM); inhibits proliferation and colony formation in A549 cancer cells expressing mutant K-Ras, as well as FaDu cancer cells expressing wild-type K-Ras at 5 µM; enhances radiation-induced cytotoxicity in K-Ras-expressing A549 and MDA-MB-231 cancer cells, but not FaDu, HTB-35, or HH4dd cancer cells that express wild-type K-Ras; reduces tumor growth in A431 and FaDu mouse xenograft models at 70 and 60 mg/kg per day, respectively
Medchemexpress LLC Fractalkine/CX3CL1 50ug | 50ug
The Fractalkine/CX3CL1 protein is a multifunctional chemokine that binds to CX3CR1 and the integrins ITGAV ITGB3 and ITGA4 ITGB1 It regulates immune responses inflammation cell adhesion and chemotaxis Fractalkine/CX3CL1 Protein Mouse (Biotinylated HEK293 His-Avi) is the recombinant mouse-derived Fractalkine/CX3CL1 protein expressed by HEK293 with C-Avi C-His labeled tag
Medchemexpress LLC Substance P (7-11) | 51165-05-0 | 99.1% | 612.78 | 5 MG
Substance P (7-11) is a C-terminal fragment of Substance P. It is for research use only and can cause an increase in the intracellular calcium concentration. In vitro, it also increases PGE2 and collagenase production at concentrations greater than 1 μM.
- Increases PGE2 and collagenase production at concentrations greater than 1 μM
- Increases intracellular calcium concentration as measured by the fluorescent dye Fura-2
- Maximal change in intracellular calcium induced by 10 μM was 140±30 nM
Medchemexpress LLC Cibinetide (ARA290) | 1208243-50-8 | >99.9% | 1257.31 | 10 MG
Cibinetide (ARA290) is an erythropoietin (EPO) derivative that acts as a specific agonist of the erythropoietin/CD131 heteroreceptor. It is investigated for neurological disorders and has shown promise in enhancing endothelial colony-forming cell functions and attenuating EAE severity in rats. This EPO-analog peptide is notable for its potential neurotrophic and antidepressant effects without hematopoietic side-effects.
- Acts as a specific agonist of the erythropoietin/CD131 heteroreceptor
- Enhances proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells
- May have neurotrophic and antidepressant effects
- Prevents progressive worsening of glucose control in rats
- Delays onset, decreases neurologic severity, and shortens duration of EAE in a dose-dependent way
Selleck Chemical LLC Afatinib S1011-200MG
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0 5 0 4 10 14 1 nM for EGFRwt EGFR L858R EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4) respectively Afatinib induces autophagy
Medchemexpress LLC Dabrafenib | 1195765-45-7 | MFCD17215684 | 99.94% | 519.56 | 1 ML
Dabrafenib is an ATP-competitive inhibitor of Raf, with IC50s of 5 nM for C-Raf and 0.6 nM for B-RafV600E. This compound is intended for research purposes only and has demonstrated the ability to suppress PolyP-mediated vascular barrier permeability and inflammatory responses.
- ATP-competitive inhibitor of Raf
- Inhibits C-Raf with an IC50 of 5 nM
- Inhibits B-RafV600E with an IC50 of 0.6 nM
- Reduces S6P phosphorylation in A375 cells
- Suppresses PolyP-mediated vascular barrier permeability
- Downregulates HMGB1-dependent inflammatory responses
Cayman Chemical Navoximod, Purity: ≥98%, CAS: 1402837-78-8, 10 mg
An IDO1 inhibitor (IC50 = 28 nM for the recombinant human enzyme); decreases tumor volume in a Panc02 murine PDAC model at 500 mg/kg
Cayman Chemical MLN8054, Purity: ≥98%, CAS: 869363-13-3, 1 mg
An inhibitor of Aurora A kinase (IC50 = 4 nM); selective for Aurora A over Aurora B, PKC, CaMKII, Cdk2E, CK2, LCK, PKA, Chk1, Chk2, Cdk1, and Plk1 (IC50s = 0.172-100 µM); induces cell cycle arrest at the G2/M phase and the formation of abnormal mitotic spindles in HCT116 colorectal and PC3 prostate cancer cells; inhibits the growth of various cancer cells (IC50s = 0.11-1.43 µM); reduces tumor volume in HCT116 and PC3 mouse xenograft models at 30 mg/kg
Cayman Chemical RGD-targeted Proapoptotic Peptide, Purity: ≥95%, CAS: 2243207-09-0, 5 mg
A peptide; contains an integrin-binding cyclic region (CDCRGDCFC) and a region similar to a pro-apoptotic heptadimer sequence (klaklakklaklak), both of which are found in similar peptides
Medchemexpress LLC Tr-PEG2-OH 1g | 105589-77-3 | 1 G
Tr-PEG2-OH is a PEG-based linker used to connect small molecules or payloads in PROTAC and ADC synthesis. It is a non-cleavable, two-unit polyethylene glycol spacer that increases solubility and provides flexible spacing for bioconjugation.
- Used as a PROTAC linker and as a non-cleavable two-unit PEG ADC linker.
- Provides spacing and improves solubility between conjugated moieties.
- White to off-white solid with low water content (~0.31%).
- High HPLC purity reported on COA (99.45% for batch example).
- Available in small pack sizes suitable for research (e.g., 1 G).
![Medchemexpress LLC 1-[4-[5-chloro-4-(3,5-dimethyl-2-pyridinyl)-2-pyridinyl]piperazin-1-yl]-3-methylsulfonylpropan-1-one | 1373615-35-0 | MFCD22420827 | 99.3% | C20H25ClN4O3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260062.png-250.jpg)
Medchemexpress LLC 1-[4-[5-chloro-4-(3,5-dimethyl-2-pyridinyl)-2-pyridinyl]piperazin-1-yl]-3-methylsulfonylpropan-1-one | 1373615-35-0 | MFCD22420827 | 99.3% | C20H25ClN4O3S | 10MG
A potent, selective, orally active, and brain-penetrant Smoothened (Smo) antagonist for Hedgehog pathway research. The compound shows low-nanomolar affinity and inhibits Hh signaling in cellular and in vivo models, making it suitable for studies of tumor growth and brain metastasis driven by activated Hh signaling.
- Potent Smo antagonist with low-nanomolar activity.
- High selectivity for Smo versus related targets.
- Orally active and brain penetrant in preclinical studies.
- Useful for hedgehog pathway and tumor model research.
- Supplied at high purity for experimental reproducibility.
- Available in multiple small-scale pack sizes for research use.
Medchemexpress LLC Pentigetide | 62087-72-3 | 99.4% | 588.57 | 5 MG
Pentigetide is a synthetic peptide (Asp-Ser-Asp-Pro-Arg or D-S-D-P-R), also known as Human IgE Pentapeptide. This peptide cannot produce IgE inhibition in several different systems because the aspartic acids in the original peptide have been changed into an asparagine.
- Synthetic peptide
- Also known as human IgE pentapeptide
- Does not produce IgE inhibition due to altered aspartic acids
Medchemexpress LLC Ru-302 | 1182129-77-6 | HY-124066 | 98.7% | 475.53 | 5 MG
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. It effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50 in cell assays and suppresses lung cancer tumor growth.
- Pan TAM inhibitor
- Blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain
- Effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50 in cell assays
- Suppresses lung cancer tumor growth
- Targets Axl receptor
- Relevant to cancer, lung cancer, and protein tyrosine kinase/RTK research
Medchemexpress LLC Myristoyl-(Lys12,27,28)-VIP-Gly-Gly-Thr free acid | 2243219-86-3 | 99.7% | 3753.42 | 500 UG
Myristoyl-(Lys12,27,28)-VIP-Gly-Gly-Thr free acid is a high-affinity and selective VPAC2 receptor antagonist. This peptide is commonly utilized in biochemical research due to its specific targeting capabilities.
- High-affinity antagonist properties
- Selective targeting of the VPAC2 receptor
- Useful in a variety of biochemical research applications
Cayman Chemical CCZ01048 (trifluoroacetate salt), Purity: ≥98%, 5 mg
A synthetic peptide; has been conjugated to radioligands for use in PET imaging of tumors expressing MC1R and for tissue distribution studies in vivo