Protein Modification Reagents
Medchemexpress LLC Mal-amido-PEG12-NHS ester | 2101722-60-3 | 98.52% | C38H63N3O19 | 50 MG
Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. These PROTACs are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
Medchemexpress LLC M-PEG4-NH-DBCO | 2228857-36-9 | 95.0% | C28H34N2O6 | 100 MG
m-PEG4-NH-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have Azide groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in synthesis of PROTACs
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.2% | C47H61N5O9S | 50 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules
Medchemexpress LLC 17-(Boc-amino)-3,6,9,12,15-pentaoxaheptadecan-1-oic acid | 890152-41-7 | 99.9% | 395.45 g/mol | C17H33NO9 | 100 MG
t-Boc-N-amido-PEG5-acetic acid is a Boc-protected PEG5-based linker that provides a flexible, hydrophilic spacer with a terminal carboxylic acid for use in PROTAC synthesis and bioconjugation. It is compatible with standard amide-forming chemistries and is supplied at research-grade purity with available batch COAs.
- Provides a PEG5 hydrophilic spacer for reduced steric hindrance and improved solubility.
- Contains a Boc-protected amine enabling selective deprotection and downstream functionalization.
- Has a terminal carboxylic acid suitable for amide bond formation with ligands.
- High purity and batch-specific COA available for quality assurance.
- Offered in multiple package sizes for small-scale and preparative workflows.
Apexbio Technology LLC EdU Flow Cytometry Assay Kit (Cy5), 100 tests
EdU Flow Cytometry Assay Kit (Cy5) is a sensitive and reliable way to detect and quantify cell proliferation in mammalian cells. It is optimized for flow cytometry. It is a better alternative to traditional BrdU (bromodeoxyuridine). Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC DSPE-PEG-Amine, MW 5000 | 95.0% | 50 MG
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules connect two ligands, one for an E3 ubiquitin ligase and another for a target protein, leveraging the intracellular ubiquitin-proteasome system to selectively degrade specific proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Cayman Chemical PEG 2000-C-DMG 1mg
A PEGylated derivative of DMG; has been used in combination with other lipids in the formation of LNPs for the delivery of siRNA; LNPs containing C-DMG-mPEG(2000) and encapsulating siRNA targeting the genes encoding PD-L1 and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells
Nanocs Ruthenium PEG Maleimide, 5 mg
Nanocs provides Ruthenium PEG derivatives for biomedical research use, 5000 Da.
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | MFCD24539465 | 98.6% | 354.31 g/mol | C15H18N2O8 | 250 MG
Mal-PEG2-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker containing a maleimide group for thiol coupling, a two-unit polyethylene glycol (PEG2) spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. The compound is supplied for research use and is not for human therapeutic use.
- Noncleavable ADC linker with maleimide and NHS ester functional groups.
- PEG2 spacer increases hydrophilicity and reduces aggregation.
- Facilitates conjugation between thiol-containing and amine-containing molecules.
- High purity suitable for research applications.
- Soluble in DMSO; may require ultrasonic assistance for full dissolution.
Medchemexpress LLC 3,6,9,12-tetraoxatridecan-1-amine | 85030-56-4 | MFCD11041099 | 98.8% | 207.27 | C9H21NO4 | 250 MG
m-PEG4-Amine is a polyethylene glycol (PEG) based bifunctional linker bearing a terminal primary amine. It is used as a short, flexible spacer in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates, facilitating amine-based conjugation reactions.
- Provides a PEG4 spacer (~4 ethylene glycol units)
- Terminal primary amine for amide or carbamate conjugation
- High purity (98.8%) suitable for research use
- Molecular weight 207.27 g/mol
- Typically supplied as a solid; common pack size 250 MG
Medchemexpress LLC Biotin-PEG5-amine | 113072-75-6 | 96.24% | C22H42N4O7S | 100 MG
Biotin-PEG5-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled, PEG-based linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Dspe-peg-oh (mw 2000) | 99.9% | 50 MG
DSPE-PEG-OH (MW 2000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail enables encapsulation and aggregation of other hydrophobic drugs, and its hydroxyl terminus is suitable for further reactions. This product can be used to prepare liposomes or lipid nanoparticles.
- Hydroxyl-terminated PEGylated phospholipid
- Hydrophobic tail for encapsulation and aggregation of hydrophobic drugs
- Hydroxyl terminus suitable for further reactions
- Can be used to prepare liposomes or lipid nanoparticles