Protein Modification Reagents
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 1 G
Biotin-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to harness the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a protein of interest.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Facilitates selective degradation of target proteins
- Engages the ubiquitin-proteasome system
Medchemexpress LLC Biotin-PEG4-amide-Alkyne | 1006592-45-5 | 96.41% | C24H40N4O7S | 100 MG
Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. PROTACs themselves are compounds that feature two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein of interest. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Can be used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Allows for selective degradation of target proteins.
Medchemexpress LLC Biotin-PEG4-amide-Alkyne | 1006592-45-5 | 96.41% | C24H40N4O7S | 50 MG
Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing azide groups
Medchemexpress LLC Biotin-PEG2-azide | 1910803-72-3 | 97.0% | 1 G
Biotin-PEG2-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 5 G
Biotin-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTAC. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTAC
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 100 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs involve two distinct ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group for CuAAc reaction
- Can undergo SPAAC reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC DSPE-PEG-COOH | No CAS number listed for this product (HY-W591461). | No MFCD number listed for this product (HY-W591461). | 100.0% | 2000 (average) | No chemical formula listed for this product (polymeric PEG; variable repeat unit). | 25 MG
DSPE-PEG-COOH, MW 2000 is a PEGylated phospholipid used to formulate liposomes and lipid nanoparticles. It is supplied as a white to off-white solid and features a terminal carboxylic acid that can be activated to form stable amide bonds with primary amines for surface conjugation. Typical storage is -20°C, sealed, away from moisture.
- Terminal carboxylic acid for amide bond conjugation.
- Suitable for liposome and lipid nanoparticle formulation.
- White to off-white solid for easy handling and weighing.
- Available in small research pack sizes for lab use.
- High purity suitable for research use (purity ≥99.9%).
Medchemexpress LLC PC-Biotin-PEG4-NHS carbonate | 2055198-03-1 | MFCD29079395 | > 96% | 810.87 | 25 MG
PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a unique amine-reactive, photocleavable biotin reagent, making it useful for introducing a biotin moiety to amine-containing molecules. This compound also serves as a linker for bio-conjugation, featuring a terminal NHS carbonate and a photocleavable biotin group, all linked through a linear PEG chain.
- PEG-based PROTAC linker
- Amine reactive
- Photocleavable biotin reagent
- Introduces biotin moiety to amine-containing molecules
- Linker for bio-conjugation
- Contains a terminal NHS carbonate
- Linked through a linear PEG chain
Abcam Recombinant S. cerevisiae KEX2 protease protein (Active), 50UG
Recombinant S. cerevisiae KEX2 protease protein (Active) is a Saccharomyces cerevisiae S288C Fragment protein, in the 110 to 667 aa range, expressed in BTI-TN-5B1-4, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC, FuncS.
Protein/ Peptide/ Enzyme Synonyms: QDS1, YNL238W, N1122, KEX2, Kexin, Protease KEX2, Proteinase YSCF
Conjugation: Unconjugated
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Pomalidomide-PEG6-C2-COOH | 2225148-49-0 | 99.0% | C28H39N3O12 | 100 MG
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a cereblon ligand based on Pomalidomide and a 6-unit PEG linker, making it suitable for use in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Contains a 6-unit PEG linker
- Used in technology for targeted protein degradation
Medchemexpress LLC Biotin-PEG-azide | 956494-20-5 | MFCD21363313 | 95.0% | 1000 (average) | C34H64N6O13S | 25 MG
Biotin-PEG-azide (MW 1000) is a biotinylated polyethylene glycol reagent containing a terminal azide group used for bioconjugation and linker construction. It supports both copper-catalyzed azide-alkyne cycloaddition and strain-promoted alkyne-azide cycloaddition for efficient labeling, affinity capture, and linker assembly in research workflows.
- Terminal azide enables CuAAC and SPAAC click reactions.
- Biotin tag facilitates affinity capture and detection.
- Average molecular weight 1000 provides defined spacer length.
- Purity 95.0% suitable for conjugation workflows.
- Available in multiple small-scale package sizes for research use.
- Powder stable at -20°C for long-term storage.
Medchemexpress LLC Dspe-peg-nhs | MFCD03098978 | 80.0% | 5,000 Da | 50 MG
DSPE-PEG-NHS, MW 5000, is a pegylated phospholipid bearing an N-hydroxysuccinimide (NHS) reactive ester at the PEG terminus. The reagent (average MW 5,000 Da) provides an amine-reactive linker for covalent attachment of ligands to liposomes and lipid nanoparticles, while the PEG chain imparts steric stabilization and reduced protein adsorption, making it useful for formulation and bioconjugation research.
- Provides an NHS ester for covalent coupling to primary amines.
- Imparts PEGylation for steric stabilization and reduced protein adsorption.
- Enables liposome and nanoparticle surface functionalization.
- Average molecular weight approximately 5,000 Da.
- Typical purity reported as 80.0%.
- Suitable for bioconjugation and targeted drug-delivery research.
Medchemexpress LLC Cholesterol-PEG-MAL | 95.1% | 2000 (average) | 100 MG
Cholesterol-PEG-MAL (MW 2000) is a cholesterol-terminated polyethylene glycol bearing a terminal maleimide group. It serves as a pegylated lipid for liposome and nanoparticle preparation, enabling membrane anchoring and covalent conjugation to thiol-containing molecules. Supplied as a light yellow solid, it is soluble in DMSO and intended for research use.
- enables thiol-specific covalent conjugation via maleimide chemistry.
- provides a hydrophobic anchor for stable membrane insertion.
- average molecular weight 2000 for predictable spacer length.
- high purity suitable for research applications.
- soluble in DMSO at high concentration with sonication.
- stable when stored frozen as a powder.