Protein Modification Reagents
Medchemexpress LLC TCO-PEG2-amine | 2141981-87-3 | 97.0% | C15H28N2O4 | 100 MG
TCO-PEG2-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. These molecules consist of two distinct ligands connected by a linker, where one targets an E3 ubiquitin ligase and the other targets the protein of interest. PROTACs function by harnessing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC (S,R,S)-AHPC-PEG2-C4-CI | 1835705-57-1 | MFCD31560480 | ≥98.0% | 651.26 g/mol | C32H47ClN4O6S | 50 MG
(S,R,S)-AHPC-PEG2-C4-Cl is a VHL ligand-linker conjugate used as a building block in PROTAC and targeted protein degradation research. It features an (S,R,S)-configured AHPC VHL ligand linked via a PEG2-C4 spacer to a terminal chloride, typically supplied as a light yellow oil and provided at high purity for chemical biology applications.
- Includes a PEG2-C4 linker with a terminal chloride for conjugation
- Contains an (S,R,S)-configured AHPC VHL ligand moiety
- High purity suitable for synthesis and biological assays (≥98.0%)
- Molecular weight 651.26 g/mol; formula C32H47ClN4O6S
- Supplied as an oil; handle and store per safety data sheet
Medchemexpress LLC Mal-PEG4-bis-PEG4-propargyl | 1060.19 | C49H81N5O20 | 10 MG
Mal-PEG4-bis-PEG4-propargyl is a polyethylene glycol (PEG) based, cleavable linker designed for bioconjugation and antibody-drug conjugate (ADC) assembly. It features a thiol-reactive maleimide and an alkyne (propargyl) handle to enable both thiol conjugation and copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry, providing flexibility for payload attachment and linker assembly.
- Cleavable 8-unit PEG spacer for improved solubility and flexibility.
- Maleimide group for selective thiol conjugation to cysteine residues.
- Propargyl (alkyne) handle for CuAAC click chemistry.
- Suitable for synthesis of antibody-drug conjugates and other bioconjugates.
- Supplied as a 10 mg package for research-scale use.
Medchemexpress LLC Mal-amido-PEG2-C2-acid | 756525-98-1 | 99.8% | 328.32 | 5 G
Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein via a linker.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC Dbco-peg3-acid | 2754384-59-1 | 98.35% | 508.56 | 5 MG
DBCO-PEG3-acid is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates. It contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.
- Non-cleavable linker
Medchemexpress LLC Dope-peg-azide | 99.6% | 1000 (average) | 5 MG
DOPE-PEG-Azide (MW 1000) is a DOPE-based phospholipid functionalized with a polyethylene glycol (PEG) chain terminating in an azide group. The azide handle enables bioorthogonal click chemistry for conjugation and surface modification of liposomes, lipid nanoparticles, and other lipid-based formulations. The material is polydisperse with an average PEG molecular weight of 1000 and is supplied for research use.
- Provides azide functional group for copper-catalyzed or copper-free click chemistry.
- Average PEG molecular weight 1000 (polydisperse).
- High purity suitable for formulation and bioconjugation (purity listed as 99.62%).
- Suitable for liposome and lipid nanoparticle functionalization.
- Available in small pack sizes for screening and method development.
- Store at -20 °C in pure form.
eMolecules 56282-36-1 | Thiol-PEG3-alcohol | Broadpharm | MFCD04116140 | 166.240 | C6H14O3S | 98.000 | OCCOCCOCCS | 1g | 138794132
Thiol-PEG3-alcohol | Broadpharm | 56282-36-1 | MFCD04116140 | 166.240 | C6H14O3S | 98.000 | OCCOCCOCCS | 1g | 138794132
![eMolecules 956494-20-5 | Biotin-PEG11-azide | Broadpharm | MFCD21363313 | 796.980 | C34H64N6O13S | 98.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 550803943](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203029.JPG-250.jpg)
eMolecules 956494-20-5 | Biotin-PEG11-azide | Broadpharm | MFCD21363313 | 796.980 | C34H64N6O13S | 98.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 550803943
Biotin-PEG11-azide | Broadpharm | 956494-20-5 | MFCD21363313 | 796.980 | C34H64N6O13S | 98.000 | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 550803943
Cayman Chemical PomalIdomIde 25mg
An inhibitor of cereblon (IC50 = ~3 µM for the human recombinant CRBN-DDB1 complex); inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN; inhibits proliferation of U266 myeloma cells at 0.1-10 µM; reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model at 3 mg/kg per day when used in combination with dexamethasone
Medchemexpress LLC Propanoic acid, PEG4-NHPI pentafluorophenyl ester | 2101206-46-4 | >97.0% | 577.45 | C25H24F5NO9 | 100 MG
NHPI-PEG4-C2-Pfp ester is a PEG4-based pentafluorophenyl-activated linker reagent used for antibody-drug conjugate synthesis and other bioconjugation applications.
- Used as a linker reagent for antibody-drug conjugates and bioconjugation.
- High purity (≥97.0% by NMR).
- Molecular weight 577.45; chemical formula C25H24F5NO9.
- Colorless to light yellow liquid appearance.
- Storage: pure form -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Dbco-peg2-val-cit-pab-mmae | 2845934-59-8 | MFCD35133151 | 99.3% | 1569.92 | C84H120N12O17 | 50 MG
DBCO-PEG2-Val-Cit-PAB-MMAE is a cleavable antibody-drug conjugate (ADC) linker that combines a DBCO strain-promoted alkyne handle, a short PEG2 spacer, a protease-cleavable Val-Cit dipeptide, a para-aminobenzyl (PAB) self-immolative spacer, and an MMAE cytotoxic payload. It is intended for research use in ADC synthesis and click-chemistry conjugation.
- cleavable Val-Cit dipeptide for protease-triggered payload release.
- dbco click handle enables copper-free SPAAC conjugation to azides.
- peg2 spacer provides linker flexibility and solubility.
- para-aminobenzyl (PAB) self-immolative spacer facilitates payload release.
- includes a potent MMAE payload for cytotoxic activity in ADC constructs.
- supplied as a 50 mg package for laboratory research use.
Medchemexpress LLC Carboxy-PEG4-phosphonic acid | 1623791-69-4 | 96.0% | C11H23O9P | 50 MG
Carboxy-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Ald-Ph-amido-C2-PEG3-azide | 1807540-88-0 | MFCD28155209 | 98.9% | 350.37 g/mol | C16H22N4O5 | 5 MG
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker and click chemistry reagent bearing an azide functional group. It enables bioconjugation and PROTAC assembly via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC), and provides a soluble, flexible PEG spacer for linker construction.
- Contains an azide functional group for click chemistry.
- Compatible with CuAAC and SPAAC conjugation methods.
- PEG3 spacer improves solubility and linker flexibility.
- High purity suitable for research applications (>98%).
- Available in small milligram pack sizes for discovery work.
- Molecular weight 350.37 g/mol; formula C16H22N4O5.
Medchemexpress LLC HY-22335 100mg Medchemexpress, Amino-PEG4-C2-amine CAS:68960-97-4 Purity:>98%
Medchemexpress, HY-22335 100mg Amino-PEG4-C2-amine CAS:68960-97-4 Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
STA PHARMACEUTICAL US LLC Fmoc-amino-PEG3-CH2COOH | 100 g | CAS 139338-72-0 | MDL MFCD13182400
Fmoc-amino-PEG3-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 139338-72-0
- MDL: MFCD13182400
- InChIKey: XNOJSAOJCBOZTA-UHFFFAOYSA-N
- Molecular Weight: 429.469
- Molecular Formula: C23H27NO7
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
- SMILES: O=C(COCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
