Protein Modification Reagents
eMolecules 1085938-09-5 | Medchem Express | Biotin-PEG6-azide | 25mg | 722714309 | HY-140911 | 576.71 | C24H44N6O8S
Medchem Express | N-Hydroxypipecolic acid | 5mg | 515744488 | HY-N7378 | 115819-92-6 | MFCD13179004 | 145.158 | C6H11NO3
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Medchemexpress LLC m-PEG4-CH2-methyl ester | 1920109-55-2 | MFCD26318564 | >98% | C12H24O6 | 25 MG
m-PEG4-CH2-methyl ester is a PROTAC linker that is based on PEG and Alkyl/ester. It can be utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. These molecules function by harnessing the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG- and Alkyl/ester-based PROTAC linker.
- Used in the synthesis of PROTACs.
- PROTACs selectively degrade target proteins by exploiting the ubiquitin-proteasome system.
Medchemexpress LLC Benzyl-PEG4-Ots 500mg
Benzyl-PEG4-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs
Medchemexpress LLC Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-52-8 | 1559.62 | C74H98N10O27 | 10 MG
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a cleavable antibody-drug conjugate (ADC) drug-linker conjugate that combines a Mal-PEG4-VC-PAB cleavable linker with the cytotoxic payload DMEA-PNU-159682 for use in ADC research and drug-conjugate development.
- Cleavable ADC drug-linker conjugate suitable for antibody-drug conjugate synthesis.
- Contains a maleimide functional group for thiol conjugation.
- High molecular weight for payload delivery and characterization.
- Supplied in small research pack sizes for controlled studies.
- Store solid at -20°C, protect from light, and keep under inert gas; follow solvent storage recommendations for solutions.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | 663921-15-1 | MFCD11041129 | 99.9% | 265.30 g/mol | C11H23NO6 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202942.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | 663921-15-1 | MFCD11041129 | 99.9% | 265.30 g/mol | C11H23NO6 | 100 MG
NH2-PEG4-CH2CH2COOH is a cleavable four-unit polyethylene glycol (PEG) linker with an N-terminal amine and a terminal propanoic acid, designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis.
- Cleavable 4-unit PEG linker.
- Amine functional group for conjugation.
- Terminal carboxylic acid for coupling reactions.
- High purity (99.9%).
- Molecular weight 265.30 g/mol.
- Soluble in DMSO.
- Available as a 100 MG pack.
Medchemexpress LLC Dbco-PEG4-Val-Cit-PAB-MMAE | 2129164-91-4 | 99.2% | 1658.03 g/mol | C88H128N12O19 | 5 MG
DBCO-PEG4-Val-Cit-PAB-MMAE is a cleavable drug-linker conjugate that combines a DBCO-functionalized PEG4-Val-Cit-PAB linker with the cytotoxic payload MMAE. It is supplied as a white to off-white solid for use as a click-chemistry reagent and building block in antibody-drug conjugate synthesis; solutions are unstable and should be prepared fresh.
- Suitable for strain-promoted alkyne-azide cycloaddition (SPAAC)
- Val-Cit-PAB motif provides a cathepsin-cleavable linker
- MMAE payload acts as a tubulin polymerization inhibitor
- High purity supplied (99.18%)
- Provided as a solid; store powder at -20°C
Cayman Chemical BIOnT PROTAC FRGmnt lbrar 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Medchemexpress LLC Mal-PEG4-C2-NH2 TFA | 2512227-13-1 | 430.37 | 250 MG
Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Targets E3 ubiquitin ligase and target proteins
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC m-PEG4-Hydrazide | 1449390-68-4 | >98% | C10H22N2O5 | 25 MG
m-PEG4-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PROTAC linker
- PEG-based
Medchemexpress LLC Biotin-PEG4-azide | 1309649-57-7 | 99.8% | C20H36N6O6S | 25 MG
Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, facilitating both copper-catalyzed and strain-promoted cycloaddition reactions.
- Biotin-labeled and PEG-based PROTAC linker
- Essential for PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC HO-PEG24-OH | 2243942-52-9 | 99.9% | C48H98O25 | 50 MG
HO-PEG24-OH is a high-purity, polyethylene glycol (PEG)-based PROTAC linker with a purity of 99.89%. This linker is specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs), providing a versatile building block for targeted protein degradation research.
- Peg-based linker
- Designed for PROTAC synthesis
- High purity for research applications
- Supports targeted protein degradation studies
eMolecules 581065-94-3 | Tos-PEG5 t-butyl ester | Broadpharm | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
Cayman Chemical DSG-PEG 2000 1g
A PEGylated derivative of DSG; LNPs containing DSG-mPEG(2000) and encapsulating an imidazoquinoline TLR7 and TLR8 agonist and a peptide antigen EAch conjugated to PGA increase the activation of dendritic cells, macrophages, and B cells in the draining lymph node and dendritic cells and B cells in the spleen in mice compared to the non-LNP-encapsulated PGA-conjugated TLR7/8 agonist and peptide antigen.