Protein Modification Reagents
Medchemexpress LLC PROTAC SOS1 degrader-1 TFA | 98.4% | C59H77ClF4N10O6S | 1 MG
PROTAC SOS1 degrader-1 TFA is a potent PROTAC SOS1 degrader with a DC50 of 98.4 nM. It demonstrates antiproliferation activity in cancer cells with various KRAS mutations and shows an antitumor effect with low toxicity.
- Potent SOS1 degrader
- Effective in cancer cells with KRAS mutations
- Exhibits low toxicity
- Solid, white to off-white appearance
Medchemexpress LLC PTAD-PEG8-azide | 99.77% | 715.75 | 5 MG
PTAD-PEG8-azide is a cleavable ADC linker containing an azide group. It can be used in the synthesis of antibody-drug conjugates (ADCs).
- Cleavable ADC linker
- Contains an azide group
- Used in the synthesis of antibody-drug conjugates (ADCs)
Medchemexpress LLC 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44-Pentadecaoxahexatetracontan-46-amine | 2745717-94-4 | 99.9% | 691.85 | 50 MG
The m-PEG15-amine is a chemical compound with the molecular formula C31H65NO15 and a molecular weight of 691.85. It is provided as a colorless to light yellow oil with a purity of 99.91%. This product is intended for use as a laboratory chemical and in the manufacture of substances. It is classified as hazardous, causing acute oral toxicity, skin and serious eye irritation, and potential respiratory tract irritation.
- Consistent with structure based on ¹H NMR Spectrum and LCMS
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Medchemexpress LLC N-Mal-N-bis(PEG4-NHS ester) | 2112738-60-8 | ≥95.0% | C37H54N4O19 | 100 MG
N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It is designed for research applications, leveraging the intracellular ubiquitin-proteasome system for targeted protein degradation.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Connects ligands for E3 ubiquitin ligase and target proteins
- Employs ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Azido-PEG20-alcohol | 1637297-21-2 | C40H81N3O20 | 25 MG
Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent containing an Azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker for PROTAC synthesis.
- Click chemistry reagent containing an Azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 | C57H75N9O21 | 25 MG
Azide-PEG4-VC-PAB-doxorubicin is an azide-functionalized PEG4 val-cit-PAB linker conjugated to doxorubicin used to prepare antibody-drug conjugates and for click-chemistry applications.
- Contains an azide group for copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions.
- Includes a protease-cleavable Val-Cit-PAB linker for intracellular payload release.
- Contains doxorubicin as the cytotoxic payload (anthracycline class).
- High listed purity suitable for research (soluble in DMSO at 100 mg/mL).
- Store as a solid at recommended low temperatures for long-term stability.
Medchemexpress LLC Azide-peg4-tos | 168640-82-2 | 99.6% | C15H23N3O6S | 100 MG
Azide-PEG4-Tos is a PEG-based PROTAC linker for PROTAC synthesis. It acts as a click chemistry reagent with an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups, or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs use two linked ligands, one targeting an E3 ubiquitin ligase and the other a protein of interest, to selectively degrade proteins via the ubiquitin-proteasome system.
- Peg-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent with azide group
- Undergoes CuAAc with alkyne groups
- Participates in SPAAC with DBCO or BCN groups
- PROTACs: two linked ligands
- Targets E3 ubiquitin ligase and protein of interest
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC 5,8,11-trioxa-2-azatridecanoic acid, 13-hydroxy-, (4E)-4-cycloocten-1-yl ester | 1955497-82-1 | 99.3% | 345.43 g·mol⁻¹ | C17H31NO6
TCO-PEG3-alcohol is a PEG-based PROTAC linker and click-chemistry reagent featuring a trans-cyclooctene (TCO) moiety and a terminal alcohol. It is supplied as a viscous, colorless to light-yellow liquid with high stated purity and recommended cold storage, and is intended for use in bioconjugation, PROTAC assembly, and other chemical biology applications.
- Contains a trans-cyclooctene group for rapid iEDDA click reactions.
- PEG3 spacer provides hydrophilicity and conformational flexibility.
- Terminal alcohol enables additional derivatization and conjugation chemistry.
- High purity suitable for synthetic and bioconjugation workflows.
- Storage recommendations support long-term stability when kept cold.
Medchemexpress LLC CY7-N3 (Sulfo-Cyanine7-N3) | 97.6% | 763.95 | 5 MG
CY7-N3 (Sulfo-Cyanine7-N3) is a water-soluble Near-Infrared (NIR) dye azide designed for Click Chemistry. It possesses an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Water-soluble NIR dye azide
- Contains an azide group for Click Chemistry
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC)
Cayman Chemical MTDB-Alkyne 1mg
A clickable RNA pseudoknot binder; has been used in the synthesis of PINAD molecules for the degradation of SARS-CoV-2 RNA
Avanti Polar Lipids DSPE-PEG 2000 AMINE 50MG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt). 474922-26-4
Medchemexpress LLC S-acetyl-dPEG8-NHS ester | 1070798-99-0 | MFCD11041104 | 99.6% | 597.67 g·mol⁻¹ | C25H43NO13S | 25 MG
S-acetyl-dPEG8-NHS ester is a discrete polyethylene glycol bifunctional reagent designed to introduce a protected thiol into biomolecules. The NHS ester end selectively reacts with primary amines to form stable amide bonds, while the S-acetyl group can be removed to reveal a free thiol for downstream conjugation or cross-linking. The single-molecule PEG spacer provides defined length and improved solubility, enabling controlled labeling and linker construction in bioconjugation workflows.
- Provides defined PEG spacer (n = 8) for controlled spacing.
- Contains an NHS ester for conjugation to primary amines.
- Has an S-acetyl protected thiol that can be deprotected to expose a free thiol.
- Improves solubility and reduces nonspecific binding.
- Suitable for protein labeling, bioconjugation, and linker synthesis.
![eMolecules 14-(Azide-PEG3-ethylcarbamoyl)tridecanoic-t-butyl ester | Broadpharm |514.708 | C26H50N4O6 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455381](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473284.JPG-250.jpg)
eMolecules 14-(Azide-PEG3-ethylcarbamoyl)tridecanoic-t-butyl ester | Broadpharm |514.708 | C26H50N4O6 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455381
14-(Azide-PEG3-ethylcarbamoyl)tridecanoic-t-butyl ester | Broadpharm |514.708 | C26H50N4O6 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455381
Medchemexpress LLC DSPE-PEG-Maleimide | 99.8% | 50 MG
DSPE-PEG-Maleimide, MW 5000, is a linker lipid that contains DSPE phospholipid and Maleimide. It serves as a crucial component in the synthesis of various liposomal formulations, including HELDC liposomes, sterically stabilized liposomes, and immunoliposomes.
- Used as a linker lipid in immunoliposome synthesis.
- Can be coupled with thiol-p5314-29 peptide.
- Sterically stabilized liposomes containing DSPE-PEG-maleimide can be coupled with thiolated monoclonal antibody OX26 (OX26-SH).
- HELDC liposomes prepared with 3% DSPE-PEG-maleimide show no change in particle size over two weeks, with an average diameter of 120 nm.