Protein Modification Reagents
![eMolecules endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472886.JPG-250.jpg)
eMolecules endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837
endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837
Medchemexpress LLC DSPE-PEG-maleimide (MW 3400) ammonium | 474922-22-0 | >95.0% | 3,400 Da | (C2H4O)nC52H93N3NaO13P | 50 MG
DSPE-PEG-maleimide (MW 3400) ammonium is a phospholipid-polyethylene glycol conjugate bearing a terminal maleimide reactive group. Supplied as the ammonium salt with a nominal PEG molecular weight of 3,400 Da, it is used to introduce thiol-reactive functionality into lipid assemblies for site-specific conjugation and formulation of PEGylated lipid nanoparticles and nanostructured lipid carriers.
- Provides maleimide functionality for thiol-specific conjugation.
- Anchors into lipid bilayers via DSPE for stable incorporation into liposomes and nanoparticles.
- PEG chain (3,400 Da) imparts steric stabilization and extended circulation.
- Compatible with thiol-containing ligands for targeted conjugation.
- Typically supplied at ≥95% purity; store under dry and low-temperature conditions.
Medchemexpress LLC Endo-BCN-PEG2-alcohol | 1807501-85-4 | 98.0% | 325.40 | 100 MG
endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs degrade target proteins using the intracellular ubiquitin-proteasome system.
- Purity: 98.0%
- Molecular weight: 325.40
- Formula: C17H27NO5
- Appearance: Oil
- Color: Colorless to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: -20°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
Medchemexpress LLC Carboxy-PEG4-phosphonic acid | 1623791-69-4 | 96.0% | C11H23O9P | 50 MG
Carboxy-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480452.JPG-250.jpg)
eMolecules DBCO-PEG-Silane, MW 5,000 | Broadpharm |666.891 | C35H50N4O7Si | 0.000 | CCO[Si](CCCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419
DBCO-PEG-Silane, MW 5,000 | Broadpharm |666.891 | C35H50N4O7Si | 0.000 | CCO[Si](CCCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419
Medchemexpress LLC Dope-peg-azide | 99.6% | 1000 (average) | 5 MG
DOPE-PEG-Azide (MW 1000) is a DOPE-based phospholipid functionalized with a polyethylene glycol (PEG) chain terminating in an azide group. The azide handle enables bioorthogonal click chemistry for conjugation and surface modification of liposomes, lipid nanoparticles, and other lipid-based formulations. The material is polydisperse with an average PEG molecular weight of 1000 and is supplied for research use.
- Provides azide functional group for copper-catalyzed or copper-free click chemistry.
- Average PEG molecular weight 1000 (polydisperse).
- High purity suitable for formulation and bioconjugation (purity listed as 99.62%).
- Suitable for liposome and lipid nanoparticle functionalization.
- Available in small pack sizes for screening and method development.
- Store at -20 °C in pure form.
![eMolecules 642091-68-7 | t-Boc-N-Amido-PEG3-azide | Broadpharm | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1681017.jpg-250.jpg)
eMolecules 642091-68-7 | t-Boc-N-Amido-PEG3-azide | Broadpharm | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417
t-Boc-N-Amido-PEG3-azide | Broadpharm | 642091-68-7 | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417
Medchemexpress LLC Ald-Ph-amido-PEG4-C2-acid | 1309460-27-2 | 99.1% | 397.42 g/mol | C19H27NO8 | 500 MG
Ald-Ph-amido-PEG4-C2-acid is a noncleavable polyethylene glycol (PEG4) linker designed for use in antibody-drug conjugates (ADCs). It provides a stable, noncleavable connection between an antibody and a cytotoxic payload for research applications. The compound has molecular formula C19H27NO8, molecular weight 397.42 g/mol, and high purity suitable for conjugation workflows.
- Noncleavable PEG4 linker for ADC development.
- High purity, 99.1%.
- CAS number 1309460-27-2 for unambiguous identification.
- Supplied as 500 MG for laboratory-scale conjugation.
- Intended for research use only; not for human therapeutic use.
Medchemexpress LLC N3-PEG11-CH2CH2Br | 2098982-00-2 | MFCD32696701 | >98.0% | 634.56 g/mol | C24H48BrN3O11 | 25 MG
N3-PEG11-CH2CH2Br is a bifunctional PEG11 linker bearing an azide and a terminal bromoethyl group. The hydrophilic PEG11 spacer provides aqueous solubility and flexibility, allowing the molecule to serve as a versatile building block for bioconjugation and probe/linker synthesis in biochemical assays and research workflows.
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG4-CH2COOH | 10 g | CAS 437655-95-3 | MDL MFCD26142981
Fmoc-NH-PEG4-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-95-3
- MDL: MFCD26142981
- InChIKey: XPNLDOFYRFOXLR-UHFFFAOYSA-N
- Molecular Weight: 473.522
- Molecular Formula: C25H31NO8
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
- SMILES: O=C(COCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC Dbco-PEG4-VC-PAB-MMAE | 2129164-91-4 | 99.2% | 1658.03 g/mol | C88H128N12O19 | 50 MG
Drug-linker conjugate used for antibody-drug conjugate (ADC) research that couples a DBCO clickable handle and a PEG4 spacer to a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer and the cytotoxic payload monomethyl auristatin E (MMAE). Supplied as a solid for conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC) to azide-functionalized biomolecules.
- Enables SPAAC click conjugation to azide-containing biomolecules.
- Includes Val-Cit cleavable linker for intracellular payload release.
- Contains PEG4 spacer to improve hydrophilicity and reduce aggregation.
- Provided as a solid suitable for storage and DMSO formulation.
- High reported purity for reliable conjugation performance.
Medchemexpress LLC Propanoic acid, PEG4-NHPI pentafluorophenyl ester | 2101206-46-4 | >97.0% | 577.45 | C25H24F5NO9 | 100 MG
NHPI-PEG4-C2-Pfp ester is a PEG4-based pentafluorophenyl-activated linker reagent used for antibody-drug conjugate synthesis and other bioconjugation applications.
- Used as a linker reagent for antibody-drug conjugates and bioconjugation.
- High purity (≥97.0% by NMR).
- Molecular weight 577.45; chemical formula C25H24F5NO9.
- Colorless to light yellow liquid appearance.
- Storage: pure form -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC DSPE-PEG-Folate | 1236288-25-7 | 98.22% | C65H114N11O16P | 25 MG
DSPE-PEG-Folate is a PEG derivative containing folic acid with a targeting effect that binds to folate receptors in cancer cells. It forms micelles/lipid bilayers and can be used for targeted drug delivery system research. Nanoparticles constructed with DSPE-PEG-Folate and anticancer drugs primarily enter cells through the endocytosis pathway mediated by FA receptors. These nanoparticles mainly accumulate in the cytoplasm, and the released drugs are distributed in the cytoplasm and nucleus, effectively delivering drugs to the nucleus. It can also increase the elimination half-life of the drug and prolong blood circulation time.
- Contains folic acid
- Binds to folate receptors in cancer cells
- Forms micelles and lipid bilayers
- Supports targeted drug delivery system research
- Enables endocytosis pathway entry for nanoparticles
- Increases drug elimination half-life
- Prolongs blood circulation time
Medchemexpress LLC 3,6,9,12,15,18-hexaoxanonadecanoic acid | 16142-03-3 | 99.9% | 310.34 | C13H26O8 | 250 MG
m-PEG5-CH2COOH is a methyl-terminated PEG5 linker bearing a terminal carboxylic acid, designed for use in antibody-drug conjugate (ADC) and PROTAC linker synthesis as well as general bioconjugation and medicinal chemistry research.
- High purity (99.9%).
- Methyl-terminated PEG5 chain with a terminal carboxylic acid functional group.
- Suitable for ADC and PROTAC linker synthesis and general bioconjugation.
- Soluble in DMSO at 200 mg/mL; sonication recommended.
- Stable when stored sealed and protected from moisture; in solution store at -80°C (6 months) or -20°C (1 month).
- Supplied in research-scale packaging suitable for synthetic workflows.
Medchemexpress LLC (S,R,S)-AHPC-(C3-PEG)2-C6-Cl | 1835705-61-7 | MFCD31560481 | 95.0% | 749.44 g/mol | C39H61ClN4O6S | 50 MG
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a VHL ligand-linker conjugate intended for use in proteolysis-targeting chimera (PROTAC) research. It couples an (S,R,S)-AHPC VHL-binding moiety to a short PEG linker and a chlorinated C6 terminus to enable E3 ligase recruitment and target degradation in cellular assays.
- VHL ligand-linker conjugate suitable for PROTAC applications.
- Demonstrated to induce degradation of GFP-HaloTag7 in cell-based assays.
- High solubility in DMSO and ethanol; in vivo formulation options available.
- Stored at -80°C, protected from light, under inert atmosphere.
- Molecular weight 749.44 g/mol; chemical formula C39H61ClN4O6S.