Protein Modification Reagents
Medchemexpress LLC THP-PEG4-Pyrrolidine(N-Boc)-CH2OH | 2378261-80-2 | 95.0% | 25 MG
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker primarily used in the synthesis of PROTAC K-Ras Degrader-1. This compound serves as a crucial component for designing degraders that target specific proteins, utilizing the intracellular ubiquitin-proteasome system. It is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTAC K-Ras degrader-1
- Purity of 95.0%
- Molecular weight is 477.59
- Molecular formula is C23H43NO9
- Appearance is a colorless to light yellow liquid
- Store at -20°C under nitrogen
- Soluble in DMSO
Medchemexpress LLC TCO-PEG5-C2-Mal | 2748951-17-7 | 95.0% | 512.59 | 1 MG
TCO-PEG5-C2-Mal is a heterobifunctional linker that can be used for tetrazine ligation and sulfhydryl conjugation. It is for research use only and not sold to patients.
- Heterobifunctional linker.
- Can be used for tetrazine ligation.
- Can be used for sulfhydryl conjugation.
Medchemexpress LLC Endo-BCN-PEG2-NH2 | 1263166-93-3 | 97.0% | 324.42 | C17H28N2O4 | 50 MG
Endo-BCN-PEG2-NH2 is a PEG-based linker bearing a strained bicyclo[6.1.0]non-4-yne (BCN) alkyne and a terminal primary amine. It is designed for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry and is used in PROTAC synthesis and bioconjugation workflows.
- Presents BCN strained alkyne for SPAAC conjugation.
- Contains a PEG2 spacer for improved solubility and flexibility.
- Terminal primary amine available for further functionalization.
- High purity (NMR): 97.0%.
- Molecular weight: 324.42 g/mol; formula C17H28N2O4.
Medchemexpress LLC Biotin-PEG4-PFP ester | 1334172-58-5 | 96.2% | 657.65 g/mol | C27H36F5N3O8S | 25 MG
Biotin-PEG4-PFP ester is a biotinylated, cleavable PEG4 linker with a pentafluorophenyl (PFP) ester reactive group, designed for conjugation to amine-containing molecules in ADC, PROTAC, and general biotinylation workflows.
- Cleavable four-unit PEG spacer to increase solubility and flexibility.
- PFP ester reactive group for efficient coupling to primary and secondary amines.
- Biotin tag enables affinity capture, detection, and pull-down assays.
- White to off-white solid with defined storage stability in frozen conditions.
- High purity suitable for research applications and conjugation chemistry.
Medchemexpress LLC Biotin-PEG4-MeTz | 1962919-31-8 | C31H46N8O7S | 5 MG
Biotin-PEG4-MeTz is a click chemistry reagent that contains a terminal methyltetrazine group, which reacts with trans-cyclooctene. It can be used to prepare biotinylated conjugates.
- Purity: 95.32%
- Molecular weight: 674.81
- Appearance: Solid
- Color: Purple to purplish red
- Storage: -20°C, sealed, away from moisture and light
- In solvent storage: -80°C for 6 months or -20°C for 1 month (sealed, away from moisture and light)
- Solubility in DMSO: 250 mg/mL (370.47 mM), requires ultrasonication
- Designed for click chemistry applications
eMolecules Methyltetrazine-PEG5-DBCO | Broadpharm |738.842 | C40H46N6O8 | 98.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 25mg | 698442875
Methyltetrazine-PEG5-DBCO | Broadpharm |738.842 | C40H46N6O8 | 98.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 25mg | 698442875
Cayman Chemical VH 032 LInker 1 25mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting TEAD in cancer cells
Medchemexpress LLC HY-103599 100mg Medchemexpress, (S,R,S)-AHPC-PEG2-N3 CAS:2010159-45-0 Purity:>98%
Medchemexpress, HY-103599 100mg (S,R,S)-AHPC-PEG2-N3 CAS:2010159-45-0 (S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Methoxy polyethylene glycol succinimidyl carbonate | 1058691-00-1 | MFCD30828680 | 98.0% | 393.39 g/mol | C16H27NO10 | 50 MG
m-PEG5-succinimidyl carbonate is a methoxy-terminated, 5-unit polyethylene glycol succinimidyl carbonate used as a short PEG linker and an NHS carbonate reagent for conjugation to primary amines. It provides a stable, non-cleavable spacer to improve solubility and reduce steric hindrance in bioconjugation workflows such as ADC and PROTAC synthesis.
- Non-cleavable 5-unit methoxy-PEG linker.
- Reactive succinimidyl carbonate for primary amine conjugation.
- Molecular weight 393.39 g/mol.
- Purity 98.0%.
- Appearance: colorless to light yellow liquid.
- Storage: pure form -20°C (stable 3 years); in solvent -80°C (6 months), -20°C (1 month).
Medchemexpress LLC M-PEG15-NHS ester | 98.0% | 875.99 g/mol | C39H73NO20 | 5 MG
m-PEG15-NHS ester is a polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester for amine-specific conjugation. It provides a PEG15 spacer to increase solubility and flexibility during bioconjugation and linker assembly, and is supplied with defined purity and molecular weight for research applications.
- Amine-reactive NHS ester for efficient coupling to primary amines.
- PEG15 spacer to enhance solubility and reduce steric hindrance.
- High purity suitable for research-grade bioconjugation.
- Stable when stored sealed at -20°C to preserve activity.
- Designed for linker synthesis and PROTAC construction workflows.
Kyfora Bio DSPE PEG 2000 Amine 10 MG
DSPE-PEG(2000)-amine is DSPE (a phospholipid) functionalized with PEG2000. It can be used in the synthesis of solid lipid and thermosensitive nanoparticles, as well as for encapsulation of hydrophobic drugs. Functionalization with PEG prevents increases bioavailability and prevents opsonization. It has been used for the delivery of anticancer agents as well as other drug cargo. Key application(s): Drug delivery
Medchemexpress LLC En219-alkyne | 99.6% | 488.76 g·mol⁻¹ | C22H19BrClN3O3 | 5 MG
EN219-alkyne is an alkyne-functionalized covalent probe designed to engage RNF114 and enable click-chemistry labeling and activity-based protein profiling. Supplied as a light brown solid with high purity, it provides a reactive alkyne handle for biochemical conjugation and target identification studies.
- High purity of 99.62%.
- Alkyne handle for click-chemistry conjugation.
- Targets RNF114 as a covalent ligand for activity profiling.
- Molecular formula C22H19BrClN3O3 and molecular weight 488.76 g·mol⁻¹.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store sealed at -20°C; in solution store at -80°C for long-term stability.
Medchemexpress LLC MAK683-CH2CH2COOH hydrochloride | 00-00-0 | 99.6% | 484.91 g·mol⁻¹ | C23H22ClFN6O3 | 5 MG
MAK683-CH2CH2COOH hydrochloride is a PROTAC linker supplied as a high-purity solid for research use. It binds to the EED protein and has been used with an E3 ligase ligand to design PROTAC degraders. Handle and store under recommended conditions to preserve stability and activity.
- Binds to EED (embryonic ectoderm development protein).
- High purity: 99.6%.
- Molecular weight: 484.91 g·mol⁻¹.
- Physical form: solid, white to light yellow.
- Storage: keep refrigerated at 4°C and protect from light; store under inert gas for long-term stability.
- Available in small milligram packages for research workflows.
eMolecules 17-(Bromoacetamido-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |873.961 | C40H77BrN2O13 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 250mg | 490840952
17-(Bromoacetamido-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |873.961 | C40H77BrN2O13 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 250mg | 490840952