Protein Modification Reagents
Medchemexpress LLC 3,6,9-trioxa-12-azaheptadecan-17-oic acid, 1-amino-16-[[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)m | 710323-40-3 | 99.7% | 615.64 | C27H37N9O8 | 5 MG
Folate-PEG3-amine is a cleavable three-unit polyethylene glycol (PEG) linker bearing a terminal primary amine and a folate-targeting moiety. It is designed for use as a spacer in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates, facilitating folate receptor-mediated targeting in research applications.
- Cleavable three-unit PEG spacer to separate payload and targeting ligand.
- Terminal primary amine for straightforward conjugation chemistries, such as NHS esters and activated carboxyls.
- High purity suitable for research (LCMS reported 99.69%).
- Water-soluble and compatible with common bioconjugation workflows.
- Supplied in small research quantities for experimental use.
Medchemexpress LLC Amino-PEG4-GGFG-Dxd | 2879227-88-8 | MFCD09950912 | 100.0% | 1088.14 | C53H66FN9O15 | 1 MG
Amino-PEG4-GGFG-Dxd is a drug-linker conjugate designed for the synthesis of antibody-drug conjugates (ADCs). It consists of the DXd cytotoxic payload connected via a PEG4-GGFG peptide linker with a terminal amino group, and is supplied as an off-white to light yellow solid for research use only.
- Drug-linker conjugate intended for ADC synthesis.
- Contains DXd (an exatecan derivative) as the cytotoxic payload.
- PEG4-GGFG peptide linker provides spacer and protease-cleavable sequence.
- Terminal amino group enables conjugation to activated linkers or antibodies.
- High stated purity and solid form suitable for research applications.
Medchemexpress LLC Dbco-PEG4-Val-Cit-PAB-MMAF | 2244602-23-9 | 98.7% | 25 MG
DBCO-PEG4-Val-Cit-PAB-MMAF is a drug-linker conjugate used in antibody-drug conjugate research. It combines a cleavable PEG-based Val-Cit-PAB linker bearing a DBCO moiety with the tubulin inhibitor MMAF to enable enzyme-triggered payload release and bioorthogonal conjugation via SPAAC.
- Cleavable Val-Cit-PAB linker for cathepsin-mediated payload release.
- DBCO moiety enables SPAAC click chemistry with azide-functionalized partners.
- Contains MMAF tubulin inhibitor as the cytotoxic payload.
- High purity suitable for research use (approximately 98.7%).
- Available in small research pack sizes such as 25 mg.
![eMolecules Cy5-PEG3-azide | BroadpharmMFCD28142475 | 719.370 | C40H55ClN6O4 | 95.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 2mg | 263744741](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502503577.JPG-250.jpg)
eMolecules Cy5-PEG3-azide | BroadpharmMFCD28142475 | 719.370 | C40H55ClN6O4 | 95.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 2mg | 263744741
Cy5-PEG3-azide | BroadpharmMFCD28142475 | 719.370 | C40H55ClN6O4 | 95.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 2mg | 263744741
Cayman Chemical DPPE-MPEG 2000 10mg
A PEGylated form of DPPE; has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention
Medchemexpress LLC Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD | 1037589-69-7 | 99.8% | 528.55 | 100 MG
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are compounds designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Contains two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase.
- The other ligand is for the target protein.
- Utilizes the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC Dbco-peg2-dbco | 2639395-48-3 | C44H42N4O6 | 5 MG
DBCO-PEG2-DBCO is a click chemistry reagent containing a DBCO group. It is a PEG linker with two terminal DBCO groups, which are commonly used for copper-free Click Chemistry reactions due to their strain-promoted high energy. The hydrophilic PEG chain increases water solubility. This product is reagent grade and for research use only.
- Storage conditions:
- Powder: -20°C for 3 years
- In solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC 4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo | 1263045-16-4 | 99.8% | 500 MG
Mal-amido-PEG4-acid is an off-white to yellow solid with a molecular formula of C18H28N2O9 and a molecular weight of 416.42. It exhibits a high purity of 99.76% as determined by HPLC analysis, and its 1H NMR and LCMS spectra are consistent with the chemical structure.
- Off-white to yellow solid appearance
- Molecular formula C18H28N2O9
- Molecular weight 416.42
- Purity of 99.76% (HPLC)
- NMR and LCMS data consistent with structure
- Store at -20°C, protected from light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC HY-W008474 100mg Medchemexpress, PROTAC Linker 13 CAS:153086-78-3 Purity:>98%
Medchemexpress, HY-W008474 100mg PROTAC Linker 13 CAS:153086-78-3 PROTAC Linker 13 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 13 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD | 1037589-69-7 | 99.8% | 528.55 | 25 MG
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- Used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- For research use only.
eMolecules 882847-34-9 | FmocNH-PEG6-CH2CH2COOH | Acrotein ChemBio Inc. | MFCD06656474 | 575.655 | C30H41NO10 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 487561647
FmocNH-PEG6-CH2CH2COOH | Acrotein ChemBio Inc. | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 487561647
Medchemexpress LLC (S,R,S)-AHPC-PEG2-N3 | 2010159-45-0 | 99.9% | 601.72 g/mol | C28H39N7O6S | 5 MG
(S,R,S)-AHPC-PEG2-N3 is an E3 ligase ligand-linker conjugate bearing a terminal azide for click chemistry, used as a building block in PROTAC synthesis and bioconjugation.
- Terminal azide enables copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- Two-unit PEG linker provides solubility and spacer functionality.
- Designed for conjugation to alkyne, DBCO, or BCN functional partners.
- Supplied in small-quantity formats for research and synthesis workflows.
- Molecular weight 601.72 g/mol; molecular formula C28H39N7O6S.
eMolecules 123502-57-8 | Bis-PEG11-NHS ester | Broadpharm | MFCD30527397 | 796.817 | C34H56N2O19 | 95.000 | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 500mg | 340377030
Bis-PEG11-NHS ester | Broadpharm | 123502-57-8 | MFCD30527397 | 796.817 | C34H56N2O19 | 95.000 | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 500mg | 340377030
Medchemexpress LLC Mal-PEG8-Phe-Lys-PAB-Exatecan TFA | 98.7% | 1548.58 | 5 MG
Mal-PEG8-Phe-Lys-PAB-Exatecan TFA is an agent-linker conjugate for antibody-drug conjugates (ADC), composed of the degradable linker Mal-PEG8-Phe-Lys-PAB and the toxin molecule Exatecan. This agent is intended for research use only.
- Composed of degradable linker Mal-PEG8-Phe-Lys-PAB
- Contains toxin molecule Exatecan
- Carries a highly potent small-molecule toxin
- Targets specific antigens of tumor cell surfaces with high binding affinity
- Internalized into tumor cells and digested in lysosome to release antitumor toxin