Protein Modification Reagents
Medchemexpress LLC Biotin-PEG4-Amide-C6-Azide | 1006592-62-6 | 99.1% | C27H49N7O7S | 100 MG
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling specific reactions with other molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC (S,R,S)-AHPC-PEG2-acid | 2172820-09-4 | 98.9% | C30H42N4O8S | 250 MG
(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It exploits the intracellular ubiquitin-proteeosome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-acid) | 2110449-00-6 | 96.7% | C33H40N2O10 | 100 MG
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent, containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with Azide groups
eMolecules 1334177-86-4 | Mal-amido-PEG8-C2-acid | Medchem Express (US) | MFCD13184956 | 592.639 | C26H44N2O13 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 894458958
Mal-amido-PEG8-C2-acid | Medchem Express (US) | 1334177-86-4 | MFCD13184956 | 592.639 | C26H44N2O13 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 894458958
Medchemexpress LLC Bis-aminooxy-PEG4 | 98627-72-6 | 96.0% | C10H24N2O6 | 100 MG
Bis-aminooxy-PEG4 is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras), which contain two distinct ligands connected by a linker. One ligand targets an E3 ubiquitin ligase, while the other targets a protein of interest. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker for PROTAC synthesis
- Enables selective degradation of target proteins
- Utilizes the ubiquitin-proteasome system
- Light yellow to yellow liquid appearance
Medchemexpress LLC DBCO-mPEG (MW 5kDa) | 99.1% | 25 MG
DBCO-mPEG (MW 5kDa) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group capable of strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs utilize the intracellular ubiquitin-proteasome system for the selective degradation of target proteins by connecting an E3 ubiquitin ligase ligand and a specific protein target ligand with a linker.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group for SPAAC with azide groups
- Used in the synthesis of PROTACs
- Leverages the ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC Azide-PEG5-Tos | 236754-49-7 | MFCD28505520 | 98.5% | 417.48 g/mol | C17H27N3O7S | 250 MG
Azide-PEG5-Tos is a cleavable five-unit polyethylene glycol (PEG5) linker bearing an azide functional group and a tosyl leaving group. It is used as a click-chemistry compatible linker and crosslinker for antibody-drug conjugates (ADCs) and other bioconjugation applications.
- Cleavable five-unit PEG linker suitable for ADC synthesis.
- Azide functional group enables CuAAC and strain-promoted cycloaddition.
- High purity suitable for research applications.
- Soluble in DMSO at ≥100 mg/mL.
- Molecular weight 417.48 g/mol; chemical formula C17H27N3O7S.
- Available in milligram to gram pack sizes, including 250 MG.
eMolecules Cbz-N-amido-PEG15-amine | BroadpharmMFCD30723279 | 855.029 | C40H74N2O17 | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCc1ccccc1 | 1g | 340376868
Cbz-N-amido-PEG15-amine | BroadpharmMFCD30723279 | 855.029 | C40H74N2O17 | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCc1ccccc1 | 1g | 340376868
eMolecules 518044-31-0 | Hydroxy-PEG3-CH2CO2tBu | Apollo Scientific | MFCD27977510 | 264.318 | C12H24O6 | 0.000 | CC(C)(C)OC(=O)COCCOCCOCCO | 1g | 591806870
Hydroxy-PEG3-CH2CO2tBu | Apollo Scientific | 518044-31-0 | MFCD27977510 | 264.318 | C12H24O6 | 0.000 | CC(C)(C)OC(=O)COCCOCCOCCO | 1g | 591806870
Medchemexpress LLC PROTAC SOS1 degrader-1 TFA | 98.4% | C59H77ClF4N10O6S | 1 MG
PROTAC SOS1 degrader-1 TFA is a potent PROTAC SOS1 degrader with a DC50 of 98.4 nM. It demonstrates antiproliferation activity in cancer cells with various KRAS mutations and shows an antitumor effect with low toxicity.
- Potent SOS1 degrader
- Effective in cancer cells with KRAS mutations
- Exhibits low toxicity
- Solid, white to off-white appearance
Cayman Chemical PROTAC CRBN Degrader-1 1mg
A PROTAC that drives CRBN degradation (DC50 = 200 nM in HeLa cells)
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 | C19H22N2O8 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203957.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 | C19H22N2O8 | 250 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugation (ADC). It features an activated N-hydroxysuccinimide (NHS) ester for amine coupling and a para-formylbenzoyl aldehyde for conjugation chemistry. The product is supplied as a colorless to light-yellow liquid with high purity and is intended for research use.
- Noncleavable two-unit PEG linker suitable for ADC construction.
- NHS ester for efficient amine coupling.
- Aldehyde (formyl) functional group for site-specific conjugation.
- High purity (approximately 98.5%).
- Liquid, colorless to light yellow appearance.
- Molecular weight 406.39 and formula C19H22N2O8.
- Storage: pure form -20°C; in solvent -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC H-151 Alkyne | 2244892-03-1 | 95.1% | 275.30 | 25 MG
H-151 Alkyne (Compound H-151-AL) is a selective STING (Stimulator of interferon genes) inhibitor. It is promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases.
- Selective STING (Stimulator of interferon genes) inhibitor.
- Promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases.
eMolecules 88504-24-9 | m-PEG36-Mal | Broadpharm | MFCD21363231 | 1768.087 | C80H154N2O39 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 100mg | 279709052
m-PEG36-Mal | Broadpharm | 88504-24-9 | MFCD21363231 | 1768.087 | C80H154N2O39 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 100mg | 279709052