Protein Modification Reagents
Medchemexpress LLC Pomalidomide-5'-PEG8-C2-COOH | 2138440-78-3 | 98.2% | 697.73 | C32H47N3O14 | 50 MG
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate intended as a building block for proteolysis-targeting chimera (PROTAC) synthesis. The molecule combines a pomalidomide-derived warhead with an eight-unit polyethylene glycol (PEG8) spacer and a terminal two-carbon carboxylic acid for coupling, supplied as a high-purity solid for research use.
- Designed for PROTAC construction and E3 ligase engagement.
- Pomalidomide-derived warhead with PEG8 spacer and terminal carboxylic acid for conjugation.
- High reported purity suitable for synthetic applications.
- Soluble in DMSO at high concentration for stock solutions.
- Recommended long-term storage at low temperatures to preserve integrity.
Medchemexpress LLC Biotinyl-NH-PEG3-C3-amido-C3-COOH | 1202761-21-4 | 99.3% | 100 MG
Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This solid, white to off-white compound offers high purity and is intended for research applications.
- High purity of 99.25%
- PEG-based PROTAC linker
- Suitable for synthesis of PROTACs
- Soluble in DMSO and methanol
- For research use only
eMolecules 1374666-32-6 | MAL-PEG2-ACID | AstaTech | MFCD23726620 | 257.242 | C11H15NO6 | 95 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 0.25g | 464144612
Ambeed | (2S3R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(((benzyloxy)(hydroxy)phosphoryl)oxy)butanoic acid | 250mg | 490530784 | A197511 | 175291-56-2 | MFCD00797870 | 511.467 | C26H26NO8P
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Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 25 MG
(S,R,S)-AHPC-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. It incorporates an (S,R,S)-AHPC based VHL ligand and a 5-unit PEG linker. This compound targets the VHL protein, a key subunit of Cullin RING E3 ubiquitin ligase complexes, facilitating ubiquitination and subsequent proteasomal degradation of target proteins. It is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates (S,R,S)-AHPC based VHL ligand
- Features a 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein to induce target protein degradation
- For research use only
- Appears as a colorless to off-white solid
- Store at -20°C under nitrogen
Medchemexpress LLC 3,6,9,12-tetraoxatridecan-1-amine | 85030-56-4 | 98.8% | 207.27 g/mol | C9H21NO4 | 5 G
m-PEG4-Amine is a methoxy-terminated polyethylene glycol (PEG4) linker with a terminal primary amine used as a cleavable linker for antibody-drug conjugates (ADCs) and as a PEG-based linker in PROTAC synthesis. The compound has CAS 85030-56-4, molecular weight 207.27 g/mol, and is typically supplied as a colorless to light yellow liquid.
- Primary amine functional group suitable for conjugation chemistry.
- Methoxy-terminated PEG4 spacer provides solubility and flexibility.
- Cleavable linker applications for ADC and PROTAC synthesis.
- Stable when stored protected from light at recommended temperatures.
- Colorless to light yellow liquid, easy to handle in solution-phase chemistry.
Medchemexpress LLC Folic acid-PEG5-maleimide | 00-00-0 | 99.5% | 783.78 g/mol | C35H45N9O12 | 5 MG
FA-PEG5-Mal (folic acid-PEG5-maleimide) is a polyethylene glycol-based bifunctional linker that combines a folic acid recognition unit with a terminal maleimide for thiol coupling. It is intended for use in the synthesis of PROTACs and folate-targeted conjugates, providing a water-soluble spacer to connect ligands for targeted degradation or delivery.
- Provides a folic acid recognition unit for folate receptor targeting.
- Features a terminal maleimide for selective thiol conjugation.
- Uses a PEG5 spacer to impart water solubility and flexibility.
- High purity suitable for research-grade chemical synthesis.
- Available in small milligram packages for conjugation workflows.
- Stable when stored sealed and protected from moisture and light; in solvent: -80°C (6 months), -20°C (1 month).
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG4-CH2COOH | 1 g | CAS 437655-95-3 | MDL MFCD26142981
Fmoc-NH-PEG4-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 1 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-95-3
- MDL: MFCD26142981
- InChIKey: XPNLDOFYRFOXLR-UHFFFAOYSA-N
- Molecular Weight: 473.522
- Molecular Formula: C25H31NO8
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
- SMILES: O=C(COCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Chemscene ChemScene | m-PEG24-NHS ester | 250MG | CS-0114287 | 0.98 | 2395839-96-8| MFCD11041155 | 1214.39
ChemScene | m-PEG24-NHS ester | 250MG | CS-0114287 | 0.98 | 2395839-96-8| MFCD11041155 | 1214.39
Medchemexpress LLC Biotin-PEG1-NH2 | 811442-85-0 | 97.0% | 330.45 | C14H26N4O3S | 25 MG
Biotin-PEG1-NH2 is a cleavable, biotinylated one-unit polyethylene glycol (PEG1) linker with a terminal amine used for antibody-drug conjugate (ADC) synthesis and general bioconjugation research. It supplies a short hydrophilic spacer bearing a biotin affinity tag for capture or detection and a primary amine for coupling to payloads.
- Cleavable 1-unit PEG linker.
- Terminal primary amine for conjugation.
- Biotin tag for affinity capture and detection.
- Molecular weight 330.45 g·mol⁻¹.
- Purity 97.0%.
- Supplied as a white to off-white solid.
- Available in 25 MG and larger package sizes.
- Store at 4°C and protect from light; in solvent, -80°C for up to 6 months, -20°C for up to 1 month.
Medchemexpress LLC Methyltetrazine-PEG4-amine hydrochloride | 2245150-18-7 | MFCD31813569 | 99.5% | C17H26ClN5O4 | 10MG
Methyltetrazine-PEG4-amine hydrochloride is a PEG4-linked primary amine functionalized with a methyltetrazine group, provided as the hydrochloride salt. It functions as a click-chemistry reagent that undergoes rapid inverse-electron-demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) partners, enabling bioorthogonal labeling and site-specific conjugation in bioconjugation workflows. Supplied as a solid (purplish red to red) with high purity; store sealed at 4°C.
- Enables rapid iEDDA click reactions with TCO partners.
- PEG4 spacer improves solubility and flexibility.
- Terminal primary amine allows straightforward conjugation chemistry.
- Hydrochloride salt form enhances stability for storage.
- High purity (~99.5%) suitable for labeling and conjugation.
- Solid form, easy to handle and store at 4°C.
Medchemexpress LLC Mal-amido-PEG2-NHS ester | 955094-26-5 | MFCD11041137 | 99.3% | 425.39 g/mol | C18H23N3O9 | 50 MG
Mal-amido-PEG2-NHS ester is a noncleavable ADC linker containing a maleimide reactive group and an N-hydroxysuccinimide (NHS) ester. The NHS ester labels primary amines (-NH2) to form stable amide bonds, while the maleimide enables thiol conjugation for bioconjugation and linker chemistry applications.
- Noncleavable ADC linker with maleimide and NHS ester.
- Reacts with primary amines to form stable amide bonds.
- Enables thiol conjugation via the maleimide functionality.
- High purity suitable for research-grade bioconjugation.
- Supplied as a solid for easy handling and storage.
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG24-CH2CH2COOH | 100 g | CAS 2170484-59-8 | MDL MFCD11041159
Fmoc-NH-PEG24-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 2170484-59-8
- MDL: MFCD11041159
- InChIKey: NFOMZHGRFWXDGH-UHFFFAOYSA-N
- Molecular Weight: 1368.609
- Molecular Formula: C66H113NO28
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-pentacosaoxa-4-azanonaheptacontan-79-oic acid
- SMILES: OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)=O
Medchemexpress LLC Mal-PEG4-VA-PBD | 1342820-68-1 | 1294.40 g/mol | C68H79N9O17 | 1 MG
Mal-PEG4-VA-PBD is an agent-linker conjugate for antibody-drug conjugate (ADC) development that incorporates a pyrrolobenzodiazepine (PBD) cytotoxic warhead linked via a maleimide-PEG4-valine-alanine (Mal-PEG4-VA) cleavable linker. It is intended for bioconjugation to antibodies through thiol-reactive maleimide chemistry.
- Agent-linker conjugate for ADC development.
- Pyrrolobenzodiazepine (PBD) cytotoxic payload.
- Maleimide-PEG4-valine-alanine cleavable linker for thiol conjugation.
- Suitable for bioconjugation to antibodies and other thiol-containing biomolecules.
- Supplied in milligram quantities for research use.
Medchemexpress LLC Pomalidomide-PEG6-C2-COOH | 2225148-49-0 | 99.0% | C28H39N3O12 | 25 MG
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a 6-unit PEG linker used in PROTAC technology. It has a molecular weight of 609.62 and appears as a viscous liquid, light yellow to yellow in color. This product is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Contains a 6-unit PEG linker
- Used in PROTAC technology