Protein Modification Reagents
Medchemexpress LLC DSPE-PEG-Amine, MW 5000 | 95.0% | 50 MG
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules connect two ligands, one for an E3 ubiquitin ligase and another for a target protein, leveraging the intracellular ubiquitin-proteasome system to selectively degrade specific proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC TCO-PEG4-VC-PAB-MMAE | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 10 MG
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) assembly and click-chemistry bioconjugation workflows. It combines a trans-cyclooctene (TCO) click handle, a PEG4-Val-Cit-PAB cleavable linker, and the cytotoxic payload MMAE to enable site-selective conjugation and intracellular release of the payload.
- Provides a trans-cyclooctene (TCO) handle for inverse electron-demand Diels-Alder reactions with tetrazines.
- Contains a PEG4-Val-Cit-PAB cleavable linker for enzymatic payload release.
- Conjugated to MMAE to supply a potent cytotoxic payload for ADC research.
- High purity (99.3%) suitable for research and bioconjugation workflows.
- Characterized by molecular weight 1522.91 and formula C78H127N11O19.
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG3-azide | 97.0% | 977.30 | C50H97N4O12P | 10 MG
DSPE-PEG3-azide is an azide-functionalized lipid-polyethylene glycol conjugate with a triethylene glycol spacer terminating in an azide. It is provided for research use as a click-chemistry reagent to introduce azide groups into lipid assemblies, enabling surface modification and bioconjugation of micelles and nanoparticle formulations. Certificate of analysis reports a molecular weight of 977.30 and purity of approximately 97% (HPLC).
- Azide-terminated PEG spacer enables copper-catalyzed or strain-promoted click reactions.
- Amphiphilic lipid-PEG structure facilitates incorporation into micelles and liposomes.
- High purity suitable for research bioconjugation and nanoparticle preparation.
- Available in small pack sizes for method development and scale-up.
- Stable under typical storage conditions when kept desiccated and cold.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB | 1949793-41-2 | 98.9% | 777.86 | C36H55N7O12 | 10 MG
Mal-PEG4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker containing a terminal maleimide group for thiol conjugation. The construct includes a PEG4 spacer and a valine-citrulline-PAB protease-cleavable sequence to enable enzymatic payload release after internalization.
- Cleavable valine-citrulline-PAB sequence for enzyme-triggered release.
- Maleimide terminal for efficient thiol conjugation to antibodies.
- PEG4 spacer increases solubility and reduces steric hindrance.
- High supplied purity for consistent conjugation performance.
- Soluble in DMSO; recommended storage sealed and away from moisture.
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-NHS ester) | 2128735-29-3 | ≥96.0% | C41H46N4O14 | 50 MG
N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent due to its DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Functionality: PEG-based PROTAC linker.
- Application: Used in the synthesis of PROTACs.
- Mechanism: Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- Research Use: For research use only; not sold to patients.
Medchemexpress LLC t-Boc-Aminooxy-PEG4-NHS ester | 2401831-99-8 | 99.9% | C20H34N2O11 | 50 MG
t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Bromoacetamido-PEG4-NHS ester | 1260139-70-5 | 98.7% | C17H27BrN2O9 | 50 MG
Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
![eMolecules 945633-30-7 | Biotin-PEG2-azide | Broadpharm | MFCD26142991 | 400.500 | C16H28N6O4S | 96.000 | [N-]=[N+]=NCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 250mg | 247403111](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1675450.jpg-250.jpg)
eMolecules 945633-30-7 | Biotin-PEG2-azide | Broadpharm | MFCD26142991 | 400.500 | C16H28N6O4S | 96.000 | [N-]=[N+]=NCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 250mg | 247403111
Biotin-PEG2-azide | Broadpharm | 945633-30-7 | MFCD26142991 | 400.500 | C16H28N6O4S | 96.000 | [N-]=[N+]=NCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 250mg | 247403111
Medchemexpress LLC Dbco-peg4-va-pbd | 2241644-09-5 | >98.0% | 1430.6 | C80H87N9O16 | 10 MG
DBCO-PEG4-VA-PBD is a drug-linker conjugate designed for antibody-drug conjugate (ADC) research and click chemistry applications. It combines a dibenzocyclooctyne (DBCO) group for strain-promoted alkyne-azide cycloaddition (SPAAC) with a PEG4-valine-alanine spacer and a pyrrolobenzodiazepine (PBD) cytotoxic payload. The compound is supplied for research use and is handled under low-temperature, inert storage conditions.
- Contains DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC).
- Includes PEG4-valine-alanine spacer to provide linker stability.
- Delivers a pyrrolobenzodiazepine (PBD) cytotoxic payload for ADC applications.
- Molecular weight approximately 1,430.6 Da.
- Soluble in DMSO at 120 mg/mL; ultrasonic agitation recommended.
- Store at -80°C under nitrogen to maintain stability.
Medchemexpress LLC M-PEG-NHS ester (MW 5000) | 92451-01-9 | 95.0% | (C2H4O)nC7H9NO5 | 100 MG
m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound facilitates the degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system. It has an average molecular weight of 5000 and appears as a white to off-white solid. This product is for research use only.
- Peg-based protac linker
- Used in the synthesis of protacs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Average molecular weight of 5000
- White to off-white solid appearance
- For research use only
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | MFCD13184948 | 98.9% | 388.37 g/mol | C15H24N4O8 | 100 MG
N3-PEG4-C2-NHS ester is an azide-terminated polyethylene glycol (PEG4) N-hydroxysuccinimide (NHS) ester used as a bifunctional linker for bioconjugation and click-chemistry applications, including antibody-drug conjugate assembly and labeling of biomolecules.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- NHS ester reacts readily with primary amines to form stable amide bonds.
- Peg4 spacer provides hydrophilicity and conformational flexibility.
- High purity supports reliable research-grade conjugation.
- Stability under recommended cold-storage conditions for long-term use.
eMolecules 82209-36-7 | Amino-PEG8-amine | Broadpharm | MFCD28122964 | 412.524 | C18H40N2O8 | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCN | 1g | 254745498
Amino-PEG8-amine | Broadpharm | 82209-36-7 | MFCD28122964 | 412.524 | C18H40N2O8 | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCN | 1g | 254745498
eMolecules 882847-34-9 | Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 552715488
Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 552715488
eMolecules 882847-34-9 | Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 552715486
Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 552715486
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG6-CH2CH2COOH | 10 g | CAS 882847-34-9 | MDL MFCD06656474
Fmoc-NH-PEG6-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 882847-34-9
- MDL: MFCD06656474
- InChIKey: HEGZERUHBVYZPH-UHFFFAOYSA-N
- Molecular Weight: 575.655
- Molecular Formula: C30H41NO10
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azapentacosan-25-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
