Protein Modification Reagents
Medchemexpress LLC DBCO-PEG12-maleimide | 98.0% | 1027.16 g/mol | C52H74N4O17 | 5 MG
DBCO-PEG12-maleimide is a bifunctional polyethylene glycol (PEG12) linker bearing a dibenzocyclooctyne (DBCO) group for strain-promoted alkyne-azide cycloaddition and a terminal maleimide for thiol-specific conjugation. It is designed for catalyst-free click chemistry and selective cysteine conjugation in bioconjugation workflows, linker synthesis, and chemical biology applications.
- Enables copper-free click (SPAAC) reactions with azide-functionalized partners.
- Reacts selectively with thiols via the maleimide to form stable thioether bonds.
- PEG12 spacer improves solubility and provides flexible linker length.
- High purity suitable for sensitive bioconjugation applications.
- Stable when stored dry at recommended low temperatures.
CONJU PROBE LLC Methyltetrazine-PEG4-oxyamine, 25mg
A heterobifunctional linker containing a methyltetrazine moiety for inverse electron demand Diels-Alder cycloaddition reactions and an oxyamine group for oxime ligation
ABclonal Technology PEG3 Rabbit pAb
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5 exons and a common promoter and both genes are paternally expressed (PMID15203203). Alternative splicing events connect their shared 5 exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
Medchemexpress LLC DBCO-NHCO-PEG2-biotin | 2989400-08-8 | 97.1% | C35H43N5O6S | 10MG
DBCO-NHCO-PEG2-Biotin is a PEG-based click chemistry linker with a dibenzocyclooctyne (DBCO) reactive group and a PEG2 spacer, designed for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC). It is intended for bioconjugation, labeling, affinity capture, and linker assembly in chemical biology and PROTAC research.
- Enables copper-free SPAAC with azide-functionalized partners.
- Provides biotin affinity for streptavidin/avidin capture.
- Contains a PEG2 spacer for flexibility and improved solubility.
- High purity suitable for conjugation and analytical workflows.
- Available in small research-scale quantities for laboratory use.
Medchemexpress LLC Biotin-PEG2-C6-azide 100mg | 1011268-29-3 | 513.65 g/mol | C22H39N7O5S | 100 MG
Biotin-PEG2-C6-azide is a biotinylated polyethylene glycol linker bearing a terminal azide functional group used for bioconjugation, click chemistry, and PROTAC linker synthesis.
- Provides a terminal azide for copper-catalyzed azide-alkyne cycloaddition.
- Contains a PEG2 spacer to improve solubility and reduce steric hindrance.
- Biotin tag enables streptavidin-based capture and detection workflows.
- Molecular formula C22H39N7O5S; molecular weight ~513.65 g/mol.
- CAS number 1011268-29-3.
- Purity typically ≥98%; appearance white solid; store at -20 °C.
- Available in small-scale research quantities (e.g., 2 mg, 10 mg, 100 mg), packaging varies by supplier.
Medchemexpress LLC Azido-PEG1-C2-acid | 1393330-34-1 | 98.0% | 159.14 | 50MG
Azido-PEG1-C2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group. This enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules, and it can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group for click chemistry reactions
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Cy5-PEG5-azide bromide | 98.8% | C44H63BrN6O6 | 2 MG
Cy5-PEG5-azide is a PEG-based linker utilized in the synthesis of PROTACs, which are compounds designed to selectively degrade target proteins. This reagent facilitates click chemistry reactions, containing an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, or strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Enables targeted protein degradation.
- Supports efficient synthesis of degraders.
- Compatible with multiple click chemistry methods.
- Offers a versatile conjugation tool for research.
- High purity for reliable experimental results.
eMolecules 882847-34-9 | Fmoc-NH-PEG6-CH2CH2COOH | ChemScene | MFCD06656474 | 575.655 | C30H41NO10 | 96.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 25g | 844822186
Fmoc-NH-PEG6-CH2CH2COOH | ChemScene | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 96.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 25g | 844822186
Cayman Chemical GEFITINIB-BASED PROTAC 3 10MG
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
Medchemexpress LLC M-PEG4-NH-DBCO | 2228857-36-9 | 95.0% | C28H34N2O6 | 100 MG
m-PEG4-NH-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have Azide groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in synthesis of PROTACs
eMolecules 1085938-09-5 | Medchem Express | Biotin-PEG6-azide | 25mg | 722714309 | HY-140911 | 576.71 | C24H44N6O8S
Medchem Express | N-Hydroxypipecolic acid | 5mg | 515744488 | HY-N7378 | 115819-92-6 | MFCD13179004 | 145.158 | C6H11NO3
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Medchemexpress LLC TCO-PEG4-NHS ester | 1621096-79-4 | 99.2% | C24H38N2O10 | 50 MG
TCO-PEG4-NHS ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It also functions as a click chemistry reagent, capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. This reagent facilitates the creation of PROTACs, which leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a TCO group
- Undergoes inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine groups
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC m-PEG4-CH2-methyl ester | 1920109-55-2 | MFCD26318564 | >98% | C12H24O6 | 25 MG
m-PEG4-CH2-methyl ester is a PROTAC linker that is based on PEG and Alkyl/ester. It can be utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. These molecules function by harnessing the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG- and Alkyl/ester-based PROTAC linker.
- Used in the synthesis of PROTACs.
- PROTACs selectively degrade target proteins by exploiting the ubiquitin-proteasome system.
Medchemexpress LLC Dspe-peg carboxylic acid (sodium), MW 2000 | 1403744-37-5 | 98.0% | (C2H4O)nC45H86NO12P.Na | 100 MG
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid used in the preparation of drug delivery nanoparticles. It can prolong the blood circulation time and stability of liposomes, and enhance the targeting ability and cellular uptake efficiency of nanoparticles. The molecular weight is 2000 (Average), and it appears as a white to off-white solid.
- Used in preparation of drug delivery nanoparticles
- Can prolong blood circulation time and stability of liposomes
- Enhances targeting ability
- Enhances cellular uptake efficiency of nanoparticles
- For research use only