Protein Modification Reagents
Medchemexpress LLC DM1-PEG4-DBCO | 1198.79 g·mol⁻¹ | C63H80ClN5O16 | 10 MG
DM1-PEG4-DBCO is an agent-linker conjugate that combines the potent microtubule inhibitor DM1 with a DBCO-PEG4-Ahx linker to enable antibody-drug conjugate (ADC) synthesis via strain-promoted alkyne-azide cycloaddition (SPAAC). It is supplied as a solid reagent for research use only.
- Agent-linker conjugate combining DM1 with a DBCO-PEG4-Ahx linker.
- Designed for antibody-drug conjugate synthesis and bioconjugation.
- Contains DBCO for strain-promoted alkyne-azide cycloaddition (SPAAC).
- Enables conjugation to azide-containing biomolecules.
- Supplied as a solid reagent; store protected from light at -20°C.
Medchemexpress LLC 2,5-pyrrolidinedione derivative (PEG1 NHS ester) | 173414-89-6 | 97.0% | 627.55 g/mol | C26H33N3O15 | 100 MG
m-C-tri(CH2-PEG1-NHS ester) is a non-cleavable, single-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker bearing an N-hydroxysuccinimide (NHS) ester for amine coupling. Supplied as a solid for research use, it provides a stable, non-cleavable spacer that improves solubility and facilitates conjugation.
- Non-cleavable single-unit PEG linker for stable spacing
- NHS ester functionality for efficient amine conjugation
- Improves payload solubility
- Supplied as a solid with ~97.0% purity (NMR)
- Available in multiple sample sizes for research (50 mg-1 g)
Medchemexpress LLC Pomalidomide-5'-peg8-c2-cooh | 2138440-78-3 | 98.2% | 697.73 | C32H47N3O14 | 10 MG
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate that links a pomalidomide E3 ligase ligand to an eight-unit polyethylene glycol (PEG8) spacer terminated with a two-carbon carboxylic acid. It is intended as a building block for PROTAC synthesis and other E3 ligase recruitment applications.
- Used as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Conjugate of pomalidomide and a PEG8 linker with a C2 carboxylic acid terminus.
- High purity: 98.2%.
- Molecular weight 697.73 g/mol; formula C32H47N3O14.
- Soluble in DMSO (100 mg/mL) and suitable in vivo formulations (≥2.5 mg/mL).
- Storage: pure form -20°C (3 years) or 4°C (2 years).
Medchemexpress LLC 2-((1E,3Z)-3-(1-(1-((E)-Cyclooct-2-en-1-yloxy)-1,12-dioxo-5,8-dioxa-2,11-diazaheptadecan-17-yl)-3,3- | 91.1% | 775.46 | C45H63ClN4O5 | 10 MG
Cy3-PEG2-TCO is a Cy3-based fluorescent reagent containing a two-unit PEG spacer and a trans-cyclooctene (TCO) functional group. It is designed for rapid bioorthogonal conjugation via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-bearing partners and is intended for research use in labeling, imaging, and bioconjugation workflows.
- Fluorescent Cy3 dye derivative suitable for imaging and labeling.
- PEG2 spacer improves solubility and reduces steric hindrance during conjugation.
- TCO functional group enables fast, selective iEDDA click reactions with tetrazines.
- Supplied as a solid with color ranging brown to reddish brown.
- High purity (~91.1%) with molecular weight 775.46 g·mol-1.
- Store protected from light under nitrogen at -20°C; in solvent, store at -80°C for long term.
Medchemexpress LLC DNP-PEG4-acid | 858126-76-8 | >98% | 250 MG
DNP-PEG4-acid is a PEG-based PROTAC linker for the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is intended for research use only.
- PEG-based PROTAC linker
- Enables the synthesis of PROTACs
- Facilitates targeted protein degradation via the ubiquitin-proteasome system
- For research use only
Medchemexpress LLC Mal-amido-PEG12-NHS ester | 2101722-60-3 | 98.52% | C38H63N3O19 | 50 MG
Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. These PROTACs are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
Medchemexpress LLC DBCO-PEG1-NHS ester | 2228857-34-7 | 95.0% | C28H27N3O7 | 50 MG
DBCO-PEG1-NHS ester is a PEG-based PROTAC linker. It is also a click chemistry reagent that contains a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group for SPAAC
- Applicable in cancer research and targeted therapy
eMolecules Acid-PEG4-Val-Cit-PAB-MMAE | | | 50mg
Broadpharm | Acid-PEG4-Val-Cit-PAB-MMAE | 50mg | 591908388 | BP-25502 | 98.000 | | | 1399.733 | C70H114N10O19
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eMolecules Building Block Tool
eMolecules 2100306-71-4 | Bromo-PEG3-CH2CO2tBu | Broadpharm | MFCD30723231 | 327.215 | C12H23BrO5 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCBr | 500mg | 343283690
Bromo-PEG3-CH2CO2tBu | Broadpharm | 2100306-71-4 | MFCD30723231 | 327.215 | C12H23BrO5 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCBr | 500mg | 343283690
(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCC | 5mg | 718091915](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502486701.JPG-250.jpg)
eMolecules 474922-82-2 | 14:0 PEG PE, MW 550 | Broadpharm737.953 | C37H72NO11P | 95.000 | CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCC | 5mg | 718091915
14:0 PEG PE, MW 550 | Broadpharm | 474922-82-2737.953 | C37H72NO11P | 95.000 | CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCC | 5mg | 718091915
eMolecules m-PEG17-propargyl | Broadpharm | 146185-77-5 | MFCD27977517 | 774.939 | C36H70O17 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C | 250mg | 229582219
m-PEG17-propargyl | Broadpharm | 146185-77-5 | MFCD27977517 | 774.939 | C36H70O17 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C | 250mg | 229582219
eMolecules 2055023-35-1 | N-Boc-N-bis(PEG3-acid) | Broadpharm | MFCD29912757 | 525.592 | C23H43NO12 | 98.000 | CC(C)(C)OC(=O)N(CCOCCOCCOCCC(O)=O)CCOCCOCCOCCC(O)=O | 500mg | 309208999
N-Boc-N-bis(PEG3-acid) | Broadpharm | 2055023-35-1 | MFCD29912757 | 525.592 | C23H43NO12 | 98.000 | CC(C)(C)OC(=O)N(CCOCCOCCOCCC(O)=O)CCOCCOCCOCCC(O)=O | 500mg | 309208999
Medchemexpress LLC Biotin-PEG2-acid | 1365655-89-5 | MFCD22056305 | ≥97.0% | 403.49 g·mol⁻¹ | C17H29N3O6S | 250 MG
Biotin-PEG2-acid is a biotinylated polyethylene glycol linker with a terminal carboxylic acid, used as a non-cleavable ADC and PROTAC linker for bioconjugation, affinity labeling, and linker synthesis. It is supplied in small laboratory pack sizes for conjugation workflows.
- Biotinylated PEG linker with a terminal carboxylic acid for conjugation.
- Non-cleavable two-unit PEG spacer suited for ADC and PROTAC syntheses.
- High purity (≥97.0%) for reliable conjugation performance.
- Molecular weight 403.49 g·mol⁻¹; formula C17H29N3O6S.
- Available in small-scale quantities such as 250 MG.
- Store protected from light under argon at -20°C; in solvent store at -80°C for long-term.
Medchemexpress LLC 5,8-dioxa-2,11-diazatetradecanoic acid, 14-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-12-oxo... | 2675364-08-4 | 98.1% | 475.53 | C24H33N3O7 | 5 MG
BCN-endo-PEG2-maleimide is a bioconjugation reagent combining an endo-BCN strained alkyne and a maleimide thiol-reactive group linked by a PEG2 spacer. It is intended for antibody-drug conjugate (ADC) linker synthesis, click chemistry (SPAAC), and thiol conjugation in bioconjugation workflows.
- Provides strain-promoted azide-alkyne cycloaddition reactivity (endo-BCN)
- Contains a maleimide group for thiol-selective conjugation
- Short PEG2 spacer improves solubility and flexibility
- High purity suitable for research (purity 98.06%)
- Available in small pack sizes for conjugation optimization
Medchemexpress LLC Azido-PEG6-azide | 1243536-56-2 | 96.2% | 376.41 g/mol | C14H28N6O6 | 5 MG
Azido-PEG6-azide is a bifunctional PEG6 linker bearing azide groups at both termini, designed for click-chemistry conjugation and linker design in small-molecule and biomolecule synthesis. It is supplied for research use and provided in small, precisely measured packs for laboratory applications.
- Bifunctional PEG6 linker with azide groups at both ends.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation.
- Suitable for PROTAC linker synthesis and small-molecule conjugation.
- High purity (~96.2%) for reproducible synthetic results.
- Molecular weight 376.41 g/mol; formula C14H28N6O6.
- Available in small research packs, including a 5 mg option.
- Colorless to light yellow liquid; store sealed, away from moisture.