General Cell Based Assays
Eurofins Discoverx PathHunter eXpress LGR5 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0526E2ACP1L)
The PathHunter LGR5 (GPR49) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. R-spondins) based activation of LGR5 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged LGR5 and EA-tagged β-Arrestin-2. Activation of LGR5 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress AVPR1A U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0587E3CP0M)
The PathHunter AVPR1A eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. vasopressin) based activation of AVPR1A GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AVPR1A and EA-tagged β-Arrestin-2. Activation of AVPR1A stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress P2RY12 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0262E2CP0L)
The PathHunter P2RY12 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. ATP) based activation of P2RY12 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged P2RY12 and EA-tagged β-Arrestin-2. Activation of P2RY12 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent, 1MG
MW 379.5 Da, Purity >98%. Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter eXpress SSTR1 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0307E3CP5L)
The PathHunter SSTR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. somatostatin) based activation of SSTR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged SSTR1 and EA-tagged β-Arrestin-2. Activation of SSTR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter™ Human ADORA1 (A1) Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human ADORA1 (A1) Gi Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure ADORA1 (GPCR) activity via decreased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Molecular Devices FLIPR Potassium Assay Kit, Thallium Detection, Homogeneous, 96/384-well
The FLIPR Potassium Assay Kit is a fluorescence-based, cell assay for measuring functional activity of ligand- and voltage-gated potassium channels using a thallium (Tl+) indicator dye. It provides a homogeneous, no-wash protocol with enhanced signal window and improved signal-to-noise, suitable for high-throughput screening on FLIPR systems.
- Homogeneous, no-wash assay for high-throughput screening.
- Thallium-based fluorescent detection for functional potassium channel readouts.
- Designed for ligand-gated and voltage-gated K+ channel measurements.
- Explorer kit format supplies reagents sufficient for ten 96- or 384-well plates.
- Includes dye components, assay buffers, K2SO4 and Tl2SO4 solutions.
- Compatible with FLIPR instrument platforms and adaptable to 1536-well formats.
Meso Scale Discovery R-PLEX Human IL-37 ASY
The Meso Scale Discovery R-PLEX Human IL-37 Assay is a multiplex immunoassay that measures IL-37 levels in human serum plasma and cell culture supernatants It uses electrochemiluminescence (ECL) detection technology and provides high sensitivity up to 5-logs of dynamic range and low sample consumption This assay allows for the simultaneous measurement of IL-37 and other biomarkers It requires 50 L or less of sample and can be read on the MESO QuickPlex SQ 120 instrument The assay comes with a plate coated with capture antibodies detection antibodies calibrators and controls
Eurofins Discoverx cAMP Hunter eXpress OPRK1 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0088E2CP2L)
The cAMP Hunter OPRK1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. dynorphin A) based activation of OPRK1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type OPRK1, a naturally Gi/Go coupled GPCR. Upon activation of OPRK1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress MC4R CHO-K1 GPCR Assay, 10-Plate Kit. (95-0050E2CP2L)
The cAMP Hunter MC4R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. α-melanocyte stimulating hormone) based activation of MC4R GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type MC4R, a naturally Gs coupled GPCR. Upon activation of MC4R, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress PTGIR CHO-K1 GPCR Assay, 10-Plate Kit. (95-0051E2CP2L)
The cAMP Hunter PTGIR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin I2, beraprost) based activation of PTGIR GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTGIR, a naturally Gs coupled GPCR. Upon activation of PTGIR, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Genscript Corporation CHO-K1/AGTRL1/G15 Stable Cell
Recombinant CHO-K1 cells stably overexpress human apelin receptor (AGTRL1) on the surface and contain high levels of G protein G i to couple with the receptor in downstream signaling pathways
Med Vet International Zoetis QuestPlus, Equine Oral Gel, 14g Syringe
QuestPlus (moxidectin/praziquantel) Equine Oral Gel when administered at the recommended dose level of 0.4 mg moxidectin/kg and 2.5 mg praziquantel/kg (2.2 lb) body weight treats and controls large strongyles, small strongyles, encysted cyathostomes, ascarids, pinworms, hairworms, large-mouth stomach worms, horse stomach bots, and tapeworms. Also suppresses strongyle egg production for 84 days. For horses and ponies 6 months of age or older. Safe for pregnant mares. See package insert for complete product details.Products are not always manufacturer specific. Actual product appearance may differ from website image.
Eurofins Discoverx PathHunter eXpress cyno CXCR2 HEK 293 β-Arrestin GPCR Assay, 2pl Kit. (93-0981E1CCP0M)
The PathHunter cyno CXCR2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL8/IL8) based activation of cyno CXCR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged cyno CXCR2 and EA-tagged β-Arrestin-2. Activation of cyno CXCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Cynomolgus monkey version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CSF3R-JAK1 Functional Assay, 2-Plate Kit. (93-0809E3CP16M)
The PathHunter CSF3R-JAK1 Functional assay eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting CTKs. This kit assesses CSF3R activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged CSF3R cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.