Protein Purification
MilliporeSigma™ Calbiochem™ Porcn Inhibitor IV, LGK974
A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC50 from 50 pM to 1.1 nM).
MilliporeSigma™ Calbiochem™ mGlu7 Antagonist, XAP044
A blood-brain barrier permeable, potent, selective, and reversible antagonist of mGlu7 receptor (IC50 = 3.5 and 2.8 μM for mGlu7a and mGlu7b in CHO cells).
MilliporeSigma™ Calbiochem™ Dihydroorotate Dehydrogenase Inhibitor, Brequinar
An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM).
MilliporeSigma™ Calbiochem™ Windorphen
A cell-permeable, selective inhibitor p300 histone acetytransferase (IC50 = 4.2μM)
MilliporeSigma™ Calbiochem™ Mcl-1 Inhibitor II
A cell-permeable hydroxynaphthalenylthioacetate that targets Mcl-1 BH3-binding groove and selectively competes against 8nM FITC-AHA-BIM142-161 for Mcl-1, but not Bcl-xL, binding (IC50 = 310nM vs >40μM; [Mcl-1] & [Bcl-x
MilliporeSigma™ Calbiochem™ Tetrabenazine, TBZ
A monoamine-depleting agent that blocks vesicular monoamine transporter 2 activity. Promotes late-stage differentiation of Pdx1 + pancreatic progenitor cells into Ngn3 + endocrine precursors.
MilliporeSigma™ Calbiochem™ InSolution™ Glutaminase Inhibitor, Compound 968
A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10μM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cel
MilliporeSigma™ Calbiochem™ Hydroxychloroquine Sulfate
A cell-permeable compound that increases intralysosomal pH and impairs autophagic degradation process. Suppresses proliferation of human dermal fibroblasts (IC50 = 30 μM).
Novus Biologicals™ Celastrol, IL-17A (IL-17A Inhibitor)
Used in assays to inhibit IL-17A induction
MilliporeSigma™ Calbiochem™ Citalopram Hydrobromide
A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC50
MilliporeSigma™ Calbiochem™ BMI-1 Expression Inhibitor, PTC-209
A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription.
MilliporeSigma™ Calbiochem™ Cdk7 Inhibitor VIII, THZ1
A cell-permeable, non-toxic, phenylaminopyrimidinyl-acrylamide compound that acts as a highly potent, selective, ATP-site directed, and irreversible inhibitor of Cdk7 (IC50
MilliporeSigma™ Calbiochem™ MICAL-2 Inhibitor II, CCG-203971
A cell-permeable, restricted form of CCG-1423 with enhanced potency (IC50 = 4.2 μM vs 16.6 μM for PC-3 cell migration), but reduced off-target toxicity.
MilliporeSigma™ Calbiochem™ Late Endosome Trafficking Inhibitor, EGA
A cell-permeable compound that prevents various bacterial toxins from exerting their cytotoxic activity by blocking endosomal trafficking/maturation into acidified late endosomes.
MilliporeSigma™ Calbiochem™ Sphingosine Kinase-2 Inhibitor, K145
A cell permeable, selective, sphingosine competitive inhibitor of spingosine Kinase -2 (IC50 = 4.3 μM).