Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ HSP70 Inhibitor, PES-Cl
Directly binds to HSP70 and disrupts its interaction with client proteins..
Oxymetazoline Hydrochloride, USP, Spectrum™ Chemical
O1359, 2315-02-8, C16H24N2O·HCl
MilliporeSigma™ Calbiochem™ Protein Methyltransferase Inhibitor, AMI-5
The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ PI 3-Kα Inhibitor VIII
The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Ischemin
A cell-permeable azobenzene compound that reversibly targets CBP-BRD acetyl-lysine binding pocket with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B.
MilliporeSigma™ Calbiochem™ TMEM16A Inhibitor, T16Ainh-A01
The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.
MilliporeSigma™ Calbiochem™ LY 83583
A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 μM).
MilliporeSigma™ Calbiochem™ Calpain Substrate IV, Cell-Permeable, Fluorogenic
The non-permeant fluorogenic Calpain Substrate III is made cell-permeable by a c-terminal heptaarginine extension via a Glu linkage.
MilliporeSigma™ Calbiochem™ Histone Lysine Demethylase Inhibitor VIII, GSK-J4
Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS 1373423-53-0, is converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (∽ 25 to 50μM in HeLa cultures).
MilliporeSigma™ Calbiochem™ AMPK Inhibitor, Compound C
AMPK Inhibitor, Compound C, CAS 866405-64-3, is a cell-permeable compound that inhibits KDR/VEGFR2, ALK2/BMPR-I, and AMPK kinase activities (IC50 = 25.1, 148, and 234.6 nM, respectively).
MilliporeSigma™ Calbiochem™ InSolution™ Ginkgolic Acid (15:1)
A 25 mM (2 mg/231 μl) sterile-filtered solution of Ginkgolic Acid (15:1) in DMSO.
MilliporeSigma™ Calbiochem™ Notch Transcription Factor Inhibitor, SAHM1
Notch Transcription Factor Inhibitor, SAHM1, is a cell-permeable inhibitor that prevents assembly in the NOTCH1 trans-activation complex.
MilliporeSigma™ Calbiochem™ ω-Conotoxin GVIA, Conus geographus
A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses.
MilliporeSigma™ Calbiochem™ PKR/PERK Activator, DHBDC
A cell permeable dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IκBα and thereby activates NF-κB pathway.
MilliporeSigma™ Calbiochem™ Akt Activator II, SC79
Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more susceptible to phosphorylation by upstream Kinases.