Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Hydroxychloroquine Sulfate
A cell-permeable compound that increases intralysosomal pH and impairs autophagic degradation process. Suppresses proliferation of human dermal fibroblasts (IC50 = 30 μM).
MilliporeSigma™ Calbiochem™ InSolution™ APT1 Inhibitor, palmostatin B
A 50 mM (2 mg/106.23 μL) sterile-filtered solution of APT1 Inhibitor, palmostatin B in DMSO.
MilliporeSigma™ Calbiochem™ Calpain-1 Substrate II, Fluorogenic
An internally quenched peptide substrate that is optimized for calpain-1 amino acid recognition motifs at the primed as well as the non-primed sides.
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MilliporeSigma™ Calbiochem™ Ecotin, E. coli
A potent, broad range inhibitor of serine proteases.
MilliporeSigma™ Calbiochem™ Diaphanous (mDia)-related Formin Agonist, IMM01
An agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction (IC50 = 140 nM).
MilliporeSigma™ Calbiochem™ Proteasome Inhibitor I
The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ bpV(phen)
A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator.
MilliporeSigma™ Calbiochem™ InSolution™ Glutaminase Inhibitor, Compound 968
A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10μM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cel
MilliporeSigma™ Calbiochem™ PP2
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC50 = 4, 5, 5, & 100 nM for p56lck, p59fynT, Hck, & Src, respectively).
MilliporeSigma™ Calbiochem™ Porcn Inhibitor II, C59
A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat
MilliporeSigma™ Calbiochem™ Wnt Agonist I in DMSO
The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ AG 538
A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM).
MilliporeSigma™ Calbiochem™ Ischemin
A cell-permeable azobenzene compound that reversibly targets CBP-BRD acetyl-lysine binding pocket with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B.
MilliporeSigma™ Calbiochem™ Caspase-3 Inhibitor I
The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Troglitazone
A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ).