Protease Inhibitors and Phosphatase Inhibitors
Selleck Chemical LLC Tadalafil 50mg 171596-29-5 IC351
Tadalafil (IC351) is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11 *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam Dimethylo x aloylglycine, Prolyl hydro x ylase (PHD) inhibitor, 50MG
MW 250.26 Da, Purity >98%. Cell-permeable prolyl hydroxylase (PHD) inhibitor. Upregulates HIF activity. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC NSC668394 50mg | 382605-72-3 | 452.10 g·mol⁻¹ | C17H12Br2N2O3 | 50 MG
NSC668394 (7-[2-(3,5-dibromo-4-hydroxyphenyl)ethylamino]quinoline-5,8-dione) is a research-grade small-molecule inhibitor of ezrin Thr567 phosphorylation used to study cell signaling and tumor metastasis mechanisms. Supplied as a solid for laboratory research use only.
- CAS number: 382605-72-3.
- Molecular formula: C17H12Br2N2O3.
- Molecular weight: 452.10 g·mol⁻¹.
- Reported purity: 99.31% (manufacturer reported).
- Target: inhibits ezrin phosphorylation at Thr567.
- Physical form: solid powder suitable for in vitro studies.
ACROBiosystems Human IL-4 / IL-4RA Inhibitor Screening Kit (TR-FRET) is expressed from Human, 500 tests
Human IL-4 / IL-4RA Inhibitor Screening Kit (TR-FRET) is expressed from Human
Medchemexpress LLC MS7972 | 2165322-94-9 | 98.0% | 422.21 | C17H16BrF4NO2 | 50 MG
USP25/28 inhibitor AZ1 is a selective, orally active, noncompetitive small-molecule inhibitor of deubiquitinases USP25 and USP28, used for cellular and in vivo studies to probe deubiquitination pathways and disease models.
- Selective dual USP25 and USP28 inhibitor.
- Submicromolar potency: IC50 0.7 μM (USP25), 0.6 μM (USP28).
- High purity: 98.0%.
- Solid powder form suitable for in vitro and in vivo applications.
- Storage recommendations: powder -20°C long term, 4°C short term; in solvent -80°C for extended storage.
Abcam AG 490, JAK2/3 inhibitor, 50MG
MW 294.3 Da, Purity >99%. JAK2/3 inhibitor (IC₅₀ values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical AZ1 USP2528 InhIbItr 25mg
A dual inhibitor of USP25 and USP28 (IC50s = 0.7 and 0.6 µM, respectively); selective for USP25 and USP28 over USP2a (IC50 = >100 µM), a panel of 22 other deubiquitinases at 10 µM, and a panel of eight caspases and cathepsins at 30 µM; induces degradation of c-Myc in HCT116 cells, an effect that can be reversed by MG132; decreases the viability of several cancer cell lines (EC50s = 9.8-33.5 µM)
Medchemexpress LLC HY-112136 10mg Medchemexpress, TAO Kinase inhibitor 1 CAS:850467-66-2 Purity:>98%
Medchemexpress, HY-112136 10mg TAO Kinase inhibitor 1 CAS:850467-66-2 TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Abcam PMSF, protease inhibitor, 10G
MW 174.19 Da, Purity >98%. Non-specific protease inhibitor; binds key active site serine residue in serine proteases, acetylcholinesterases, and thiol proteases. Suitable for use in vitro; in the preparation of cell lysates, and in vivo where it has been shown to block anandamide (ab120429) metabolism. Able to rapidly cross the BBB.
The product is subject to the following: Abcam Restricted Use Statement
Research Products International Corp Benzamidine Hydrochloride, 100 Grams
Competitive serine protease inhibitor which forms stable complexes with and blocks the active sites of enzymes. Target enzymes include trypsin, hymotrypsin, kallikzein and plasmin.
Ubpbio A reversible inhibitor of serine and cysteine proteases. CAS# 103476-89-7, > 98% purity
Leupeptin hemisulfate (Ac-Leu-Leu-argininal) is a reversible inhibitor of serine and cysteine proteases, including plasmin, trypsin, papain, kallikrein, calpain and cathepsin B. A widely used protease inhibitor and typical working concentration is 10 - 100 μM.
Cayman Chemical FAK InhIbItr 14 25mg
A direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397 (IC50 = 1 μM); no known significant effect on the activity of a range of other kinases; promotes cell detachment and inhibits cell adhesion of cells in culture; blocks tumor growth in vivo
Cayman Chemical STOML3 InhIbItr OB-1 25mg
An inhibitor of STOML3 oligomerization; inhibits oligomerization of mouse and human STOML3 in cell-free assays at 10 µM; reduces Piezo1 channel current amplitude in Neuro2a cells; inhibits tactile perception in wild-type mice and reduces tactile allodynia in a mouse model of streptozotocin-induced diabetic neuropathy
Cayman Chemical JNK InhIbItr VII 1mg
A non-selective JNK inhibitor (IC50s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively); inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC50s = 130 and 244 nM, respectively)
Gold Biotechnology Inc Pepstatin A 100 mg
Pepstatin A is a competitive, reversible aspartic protease inhibitor and inhibits proteases such as pepsin, chymosin, renin, HIV proteases, and cathepsins D and E. Peptstatin A is highly selective and is often used in a mixture with other enzyme inhibitors. In vitro studies have shown pepstatin A is the only aspartic acid inhibitor that exhibits inhibitory effects on HIV proteases.