Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Dantrolene, Sodium Salt
A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.
MilliporeSigma™ Calbiochem™ CX546
A positive allosteric modulator selective for the AMPA receptors.
MilliporeSigma™ Calbiochem™ HDAC6 Inhibitor II, BRD9757
A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC50 = 30nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC50
MilliporeSigma™ Calbiochem™ HIF Inhibitor VII
A cell-permeable benzoxadiazolamine that prevents HIF-2α-HIF-β/ARNT heterodimeration by perturbing HIF-2α Per-ARNT-Sim/PAS-B domain surface β-sheet conformation via a 1:1 stoichiometric binding ( K D = 81nM), while exhibiting no affinity toward HIF-1αPAS-B
MilliporeSigma™ Calbiochem™ GR 127935 Hydrochloride
A selective 5-HT1B/1D receptor antagon
MilliporeSigma™ Calbiochem™ Pirenzepine Dihydrochloride
An antagonist selective for mAChR subtype M1.
MilliporeSigma™ Calbiochem™ Oxymetazoline Hydrochloride
Oxymetazoline Hydrochloride is an α2-Adrenergic receptor agonist. Enhances EGF- and PDGF-induced DNA synthesis.
MilliporeSigma™ Calbiochem™ MitoBloCK-6
A cell-permeable, stable dichlorosalicylaldehyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC50 = 700 nM, 900 nM, an
MilliporeSigma™ Calbiochem™ InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum
A 25 mM solution of (+)-Brefeldin A in DMSO.
MilliporeSigma™ Calbiochem™ Plasminogen Activator Inhibitor-1, Human, Recombinant
Primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Polo-like Kinase Inhibitor II, BTO-1
The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ α-Amyloid Precursor Protein Modulator
A cell-permeable benzolactam derived PKC activator (K
MilliporeSigma™ Calbiochem™ ATRA-BA Hybrid
The differentiation-inducer all-trans-Retinoic Acid and the histone deacetylase inhibitor (HDI) Butyric Acid.
MilliporeSigma™ Calbiochem™ Shikonin
A naphthoquinone found in the Chinese herb Shiunko.
MilliporeSigma™ Calbiochem™ P-Glycoprotein Inhibitor, C-4
The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.