Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1
A cell-permeable, superior inhibitor of Jumonji C domain histone lysine demethylase. About 30 fold more potent than IOX1 (EC50 = 3.8 μM for KDM4A in HeLa cells vs. 100 μM for IOX1).
MilliporeSigma™ Calbiochem™ MICAL-2 Inhibitor II, CCG-203971
A cell-permeable, restricted form of CCG-1423 with enhanced potency (IC50 = 4.2 μM vs 16.6 μM for PC-3 cell migration), but reduced off-target toxicity.
MilliporeSigma™ Calbiochem™ Lenaldekar (LDK)
An inhibitor of T cell proliferation (IC50 = 3 μM in CD3+, CD4+, and CD8+ cells). Does not affect other cell types.
MilliporeSigma™ Calbiochem™ Argonaute-2 Inhibitor, BCI-137
A cell-permeable, non-toxic dioxotetrahydroquinoxaline compound that mimics uridine and directly and reversibly interacts with the microRNA (miRNA) binding domain of Argonaute-2 (Ago2; KD = 126μM) and significantly inhibits binding of miR-20a, miR-26a, miR-107, miR-223, and let-7a to A
MilliporeSigma™ Calbiochem™ Estrogen Receptor Antagonist, ICI 182,780
A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.
MilliporeSigma™ Calbiochem™ IRAK4 Inhibitor, Compound 26
A cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94
MilliporeSigma™ Calbiochem™ Proteasome Substrate III, Fluorogenic
Proteasome Substrate III, Fluorogenic, is a substrate for proteasome. Also acts as a substrate for calpain, chymotrypsin, and ingensin.
MilliporeSigma™ Calbiochem™ Proteasome Inhibitor Set II
The Proteasome Inhibitor Set II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ TIRAP Inhibitor Peptide, Cell-Permeable
The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ TLR4 Inhibitor, TAK-242
TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.
MilliporeSigma™ Calbiochem™ Tpl2 Kinase Inhibitor
The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase.
MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor II
TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC50 = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).
MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor
The TGF-β RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Serine Protease Inhibitor Cocktail Set I
The Serine Protease Inhibitor Cocktail Set I controls the biological activity of Serine Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ SecinH3
A cell-permeable triazolo compound that acts as a Sec7 domain-binding, selective antagonist against cytohesin family small GEFs.