Substrates
Medchemexpress LLC Ac-Leu-Arg-AMC | 929621-79-4 | 98.2% | 486.56 | 5 MG
Ac-Leu-Arg-AMC is a fluorogenic peptide substrate used in various research applications. It is supplied as a solid with a purity of 98.2% and a molecular weight of 486.56. This compound is known for its fluorescent properties with an excitation wavelength of 390 nm and emission at 480 nm, making it suitable for fluorescence-based assays.
- Fluorogenic peptide substrate
- White to off-white solid appearance
- Excitation (Ex) at 390 nm
- Emission (Em) at 480 nm
- Soluble in DMSO (300 mg/mL)
Medchemexpress LLC Boc-Leu-Gly-Arg-AMC | 65147-09-3 | 98.3% | 601.69 | 5 MG
Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate primarily used for convertases. This compound is suitable for use in enzymatic assays. Research has shown its application in developing enzymatic assays to detect proteolytic enzymes, such as those capable of generating sodefrin, by measuring the liberation of 7-amino-4-methylcoumarin. The optimal activity for cleaving Boc-Leu-Gly-Arg-AMC in certain extracts has been observed at pH 9.0 and 45 °C.
- Fluorogenic AMC substrate for convertases.
- Can be used in enzymatic assays.
- Suitable for demonstrating the presence of proteolytic enzymes.
Sigma Aldrich Fine Chemicals Biosciences Azocasein | 102110-74-7 | MFCD00130592 | 5g
Azocasein | 102110-74-7 | MFCD00130592 | 5g
Medchemexpress LLC Z-DEVD-AFC | 1135416-11-3 | 98.1% | 821.71 | 1 MG
Z-DEVD-AFC is a cell-permeant substrate for caspase-3. It induces a shift in fluorescence upon cleavage of the AFC fluorophore and can be utilized to detect caspase-3-like enzyme activity.
- Cell-permeant substrate for caspase-3
- Causes a shift in fluorescence upon cleavage of the AFC fluorophore
- Detects caspase-3-like enzyme activity
- Fluorescent dye with excitation at 380 nm and emission at 500 nm
- Protease substrate
Medchemexpress LLC Ac-yevd-amc | 1631716-11-4 | 99.59% | 723.73 | 1 MG
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. It releases amino-4-methylcoumarin (AMC) for fluorescence detection when treated with cell lysate.
- It functions as a fluorescent substrate for caspase-1/11.
- Its mechanism involves the release of amino-4-methylcoumarin (AMC) for fluorescence detection.
- It is intended for research use only.
Medchemexpress LLC Ac-DEVD-AMC | 169332-61-0 | 99.2% | 675.64 | 100 MG
Ac-DEVD-AMC is a fluorescent substrate designed for caspase-3 and caspase-7. When incubated with cell lysate, it releases amino-4-methylcoumarin (AMC), enabling fluorescence detection at specific wavelengths.
- Fluorescent substrate for caspase-3/caspase-7
- Releases amino-4-methylcoumarin (AMC) for fluorescence detection
- Excitation wavelength of 380 nm
- Emission wavelength of 460 nm
- For research use only
Medchemexpress LLC ATR kinase substrate peptide | 1232497-16-3 | 99.30% | 1814.05 | 5 MG
ATR kinase substrate peptide (ASELPASQPQPFSAKKK) is a peptide substrate for ATR protein kinase and can be used to detect ATR kinase activity. This product is for research use only.
- Sequence: Ala-Ser-Glu-Leu-Pro-Ala-Ser-Gln-Pro-Gln-Pro-Phe-Ser-Ala-Lys-Lys-Lys
- Target: ATR (Ki 6 nM)
- Solubility in H2O: 28 mg/mL (15.44 mM; requires ultrasonic and warming)
- Appearance: Solid, white to off-white
Medchemexpress LLC Z-Gly-Gly-Arg-AMC acetate | 2070009-61-7 | 99.8% | 639.66 | 5 MG
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate used for testing thrombin generation in platelet-rich plasma (PRP) and platelet-poor plasma (PPP). This compound exhibits excitation/emission wavelengths of 390/480 nm.
- Thrombin-specific fluorogenic substrate
- Used for testing thrombin generation in PRP and PPP
- Excitation wavelength of 390 nm
- Emission wavelength of 480 nm
- For research use only
Medchemexpress LLC L-Argininamide, N-[(phenylmethoxy)carbonyl]glycylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | 66216-78-2 | 99.8% | 579.60 | 10 MG
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate designed for testing thrombin generation in PRP (platelet-rich plasma) and platelet-poor plasma (PPP). It provides specific detection with excitation at 390 nm and emission at 480 nm.
- Thrombin-specific fluorogenic substrate
- Supports thrombin generation testing in PRP and PPP
- Excitation at 390 nm, emission at 480 nm
- White to off-white solid appearance
- Purity of 99.80%
- Soluble in DMSO (100 mg/mL) and H2O (40 mg/mL)
- Stable as powder for 2 years at -80°C and 1 year at -20°C
- For research use only
Medchemexpress LLC Z-Gly-Gly-Arg-AMC | 66216-78-2 | 99.9% | 579.60 | 5 MG
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate used for testing thrombin generation in PRP (platelet-rich plasma) and PPP (platelet-poor plasma), with excitation/emission wavelengths of 390/480 nm. It is intended for research use only.
- Thrombin-specific fluorogenic substrate
- Used for testing thrombin generation in PRP and PPP
- Excitation/emission wavelengths of 390/480 nm
- Intended for research use only
ABclonal Technology c-Abl Rabbit mAb
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes including cell division adhesion differentiation and response to stress The activity of the protein is negatively regulated by its SH3 domain whereby deletion of the region encoding this domain results in an oncogene The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation suggesting a cell cycle function This gene has been found fused to a variety of translocation partner genes in various leukemias most notably the t(9 22) translocation that results in a fusion with the 5 end of the breakpoint cluster region gene (BCR MIM 151410) Alternative splicing of this gene results in two transcript variants which contain alternative first exons that are spliced to the remaining common exons
AG Scientific Inc IPTG, 500 G
IPTG known as Isopropyl-Beta-D-Thiogalactopyranoside functions as an inducer of galactosidase activity by binding to and inhibiting the repressor.It is utilized for the induction of expression from the lac promoter and derivates. IPTG is also used to differentiate recombinants from non-recombinants in cloning strategies using vectors containing the Z or Z peptide gene.CAS Number: 367-93-1Molecular Weight: 238.3 DaChemical Formula: C9H18O5SSolubility: Soluble in water (5%), renders clear colorless solutionStorage Temperature: -20CResearch or further manufacturing use only, not for food or drug use.
Medchemexpress LLC D-Luciferin 6 -methy 50mg | 24404-90-8 | 294.35 g/mol | C12H10N2O3S2 | 50 MG
D-Luciferin 6'-methyl ether is a synthetic analog of D-luciferin that acts as a firefly luciferase inhibitor and is used in biochemical assays to study luciferase activity and inhibitor profiling. It is typically supplied as a solid with high purity and characterized by a molecular weight of approximately 294.35 g/mol.
- Acts as a firefly luciferase inhibitor.
- Suitable for luciferase inhibition and biochemical assays.
- Supplied as an off-white to light yellow solid.
- Molecular weight 294.35 g/mol.
- Purity typically greater than 95%.
Sino Biological Peptide Substrates: Modified PKA Substrate
The modified PKA Substrate peptide sequence (modified-CGRTGRRNSI-amide) is based on the cAMP-dependent protein kinase inhibitor alpha (amino acid 15-23).
Biotium HER-2 / CD340(HRB2/718), CF740 conjugate, 0.1mg/mL
Recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.