Isotopically Labeled Compounds
Medchemexpress LLC Nateglinide-d5 | 1227666-13-8 | 98.0% | 5 MG
Nateglinide-d5 is a deuterium-labeled derivative of Nateglinide, a D-phenylalanine derivative. Nateglinide acts as an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. It inhibits ATP-sensitive K+ channels in pancreatic β-cells and is used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS
Medchemexpress LLC Riboflavin-d3 (Vitamin B2-d3) | 83-88-5 | 99.9% | 5 MG
Riboflavin-d3, also known as Vitamin B2-d3 or E101-d3, is the deuterium labeled form of Riboflavin. Riboflavin is an easily absorbed micronutrient that plays a key role in maintaining health in humans and other animals. This product is intended for research use only.
- Tracer.
- Internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes like deuterium into drug molecules for quantitation during drug development.
- Potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Thiamphenicol-d3-1 | 1217723-41-5 | 99.0% | 1 MG
Thiamphenicol-d3-1 is a deuterium-labeled form of Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol. It acts as a broad-spectrum antimicrobial antibiotic by binding to the 50S ribosomal subunit, inhibiting protein synthesis and resulting in a bacteriostatic effect against Gram-negative, Gram-positive aerobic, and anaerobic bacteria. Deuteration can influence the pharmacokinetic and metabolic profiles of drugs, and stable heavy isotopes are incorporated for quantitation during drug development.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Exhibits broad-spectrum antimicrobial activity
- Inhibits protein synthesis by binding to the 50S ribosomal subunit
- Effective against Gram-negative, Gram-positive aerobic, and anaerobic bacteria
Medchemexpress LLC Thioridazine-d3 hydrochloride | 1189928-36-6 | 98.3% | 1 MG
Thioridazine-d3 hydrochloride is the deuterium-labeled version of Thioridazine, which is an antagonist of dopamine receptor D2 family proteins. It demonstrates potent anti-psychotic and anti-anxiety effects. Additionally, Thioridazine is a strong inhibitor of PI3K-Akt-mTOR signaling pathways, exhibiting anti-angiogenic properties and showing antiproliferative and apoptosis induction in various cancer cell types, particularly targeting cancer stem cells (CSCs).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Sulfathiazole-d4 | 1020719-89-4 | 99.9% | 5 MG
Sulfathiazole-d4 is a deuterium labeled Sulfathiazole. Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRNA expression of CYP17, CYP19, and 3β-HSD. It increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Enhances the activity of CYP19 in human adrenal cancer cells (H295R)
- Upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD
- Increases the production of 17-estradiol (E2)
- Has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish
Medchemexpress LLC Diethyltoluamide-d7 | 1219799-37-7 | 98.5% | 5 MG
Diethyltoluamide-d7 is the deuterium-labeled form of Diethyltoluamide, which is widely recognized as the primary active ingredient in insect repellents. It is formulated to offer protection against a broad spectrum of biting insects, including mosquitoes, ticks, fleas, chiggers, and leeches. This compound is intended for research purposes only.
- Deuterium labeled diethyltoluamide.
- Can be used as a tracer.
- Can serve as an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as deuterium, are incorporated into drug molecules for quantitation during drug development.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Penicillin V-d5 potassium (phenoxymethylpenicillin-d5 potassium salt) | 2699607-22-0 | 98.10% | 1 MG
Penicillin V-d5 potassium is the deuterium labeled Penicillin V Potassium. Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic that inhibits the growth of Streptococci, C. difficile, and S. aureus. It can be used for research on otitis, sinusitis, pharyngitis, and tonsillitis.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- For research use only.
Medchemexpress LLC Mirtazapine-d3 | 1216678-68-0 | 99.7% | 1 ML
Mirtazapine-d3 is a deuterium labeled Mirtazapine, which is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions by blocking 5-HT2 and 5-HT3 receptors, and is intended for research use only.
- Deuterium labeled Mirtazapine
- 5-HT receptor inhibitor
- Potent noradrenergic and specific serotonergic antidepressant (NaSSA) agent
- Blocks 5-HT2 and 5-HT3 receptors
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
Medchemexpress LLC Diclazuril-d4 | 1632495-80-7 | 97.8% | 1 MG
Diclazuril-d4 is a deuterium labeled Diclazuril, a potent and orally active anticoccidial agent. It is used in the research of infectious and parasitic diseases like coccidiosis, acute toxoplasmosis, and equine protozoal pyoencephalitis (EPM). It can also serve as a tracer and internal standard for quantitative analysis.
- Deuterium labeled form of Diclazuril
- Potent and orally active anticoccidial agent
- Tracer and internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Molecular weight: 411.66
- Formula: C17H5D4Cl3N4O2
- Appearance: Solid, white to yellow
- Purity: 97.8%
Medchemexpress LLC Terazosin-d8 | 1006718-20-2 | 99.2% | 1 MG
Terazosin-d8 is a deuterium labeled version of Terazosin, a quinazoline derivative and a competitive, orally active α1-adrenoceptor antagonist. It functions by relaxing blood vessels and opening the bladder, showing potential for treating benign prostatic hyperplasia (BPH) and high blood pressure. Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Competitive and orally active α1-adrenoceptor antagonist
- Relaxing blood vessels and opening the bladder
- Potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment
Medchemexpress LLC D-Glucose-13C-5 | 106032-62-6 | >98.0% | 50 MG
D-Glucose-13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is a significant carbohydrate in biology. It serves as a carbohydrate sweetener and a critical component of general metabolism, also functioning as a crucial signaling molecule related to both cellular metabolic status and biotic and abiotic stress responses. Stable heavy isotopes, such as carbon-13, are incorporated into drug molecules for use as tracers in quantitative analysis during drug development.
- Labeled with 13C isotope
- Monosaccharide, significant carbohydrate in biology
- Functions as a crucial signaling molecule
- Used as a tracer in quantitative analysis
- Molecular formula C5¹³CH12O6
- Molecular weight 181.15
- Target: Endogenous Metabolite; Isotope-Labeled Compounds
- Pathway: Metabolic Enzyme/Protease; Others
- In Vitro Solubility: H2O: 30 mg/mL (165.61 mM; Need ultrasonic)
Medchemexpress LLC Tristearin-d5 | 55256-03-6 | 98.9% | 50 MG
Tristearin-d5 is a deuterium labeled triglyceride derived from three units of stearic acid. It is intended for research use only, not for patient use. Stable heavy isotopes, such as deuterium in Tristearin-d5, are often incorporated into drug molecules for use as tracers during the drug development process, with the potential to influence pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC D-Glucose-13C2 | 201741-04-0 | 98.0% | 5 MG
D-Glucose-13C2 is a 13C labeled form of D-Glucose, a vital monosaccharide in biology. D-Glucose functions as a carbohydrate sweetener and plays a crucial role in general metabolism. It also serves as a critical signaling molecule involved in cellular metabolic status and responses to biotic and abiotic stress.
- Can be used as a tracer for various applications.
- Serves as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes aids in quantitation during drug development.
Medchemexpress LLC 1-Pyrrolidine-2,2,3,3,4,4-d6-acetamide, α-ethyl-5-oxo-, (αS)- | 1133229-30-7 | 98.7% | 176.25 | 100 MG
Levetiracetam-d6 (ring-d6) is an internal standard designed for determining Levetiracetam content in whole blood. This product is for research use only and not sold to patients.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC DPPC-d9 (Synonyms: 129Y83-d9) | 63-89-8 | 95.0% | 743.09 | 100 MG
DPPC-d9 is a deuterium-labeled DPPC. DPPC is a zwitterionic phosphoglyceride used for preparing liposomal monolayers. DPPC-liposome effectively serves as a delivery vehicle for inducing immune responses against GSL antigen in mice.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.