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Products for use in the clinical diagnosis of viral infections, including SARS-CoV-2, the virus that causes COVID-19, by simultaneously measuring multiple analytes from a single sample.
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 1 Mouse IgA Kit is an electrochemiluminescence immunoassay for quantifying IgA antibodies to SARS-CoV-2 in mouse serum and plasma It uses plates coated with spike protein S1 and nucleocapsid protein antigens to capture antibodies with detection via SULFO-TAG labeled anti-mouse IgA The kit includes reagents for 96 tests offering sensitivity comparable to ELISA Results are available in hours using an MSD instrument aiding vaccine and therapeutic development in mouse models
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The Meso Scale Discovery V-PLEX Neuroinflammation Panel 1 Human Kit is a multiplex immunoassay for measuring biomarkers related to neuroinflammation and neurodegeneration It includes a 96-well plate detection antibodies calibrators controls diluent wash buffer read buffer and plate seals It measures human amyloid beta 1-42 amyloid beta 1-40 total tau phosphorylated tau C-reactive protein S100B and GFAP in serum plasma CSF and cell culture supernatants aiding research on Alzheimer s brain injury stroke and other neuroinflammatory conditions using electrochemiluminescence detection
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The Mesoscale K15696U-2 is a high-performance thermoelectric module for cooling featuring 127 Bismuth Telluride thermocouples between ceramic substrates It achieves a 70 C temperature difference and 31 5 Watts cooling power Measuring 40 x 40 x 3 4mm it has a low profile for effective heat spreading Optimal operation is at 25 C hot side and 0 C cold side requiring a heat sink and fan This module allows precise temperature control for electronics and photonics applications
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The Meso Scale Discovery V-PLEX Human C-Peptide Kit is an electrochemiluminescent immunoassay for the quantitative measurement of C-peptide in human serum plasma and culture media samples The assay utilizes MSD s proprietary V-PLEX technology is highly sensitive has a broad dynamic range of 78-20 000 pg/mL and shows minimal cross-reactivity The kit includes a 96-well plate coated with capture antibodies detection antibodies labeled with MSD SULFO-TAG calibrators and reagents required to perform the assay Sample incubation time is 2 hours The kit can aid in monitoring endogenous insulin production and has applications in diabetes research
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The K25395U-4 is a high-performance low-power radiation-hardened 16Kb SRAM produced by Honeywell International Inc It is constructed with Silicon-on-Insulator (SOI) CMOS technology and screened for high-reliability space applications The K25395U-4 operates from a single 3 3V power supply and has a maximum standby current of 100 A It has a 16 384 x 1 organization TTL-compatible inputs and single-ended CMOS outputs This SRAM is fully static and does not require a periodic refresh to retain data It is available in a hermetic 68-pin flat pack and is guaranteed for total ionizing dose radiation hardness assurance from 30 krad(Si) to 1 Mrad(Si)
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 2 Mouse IgG Kit is an electrochemiluminescence immunoassay that detects IgG antibodies to SARS-CoV-2 in mouse serum and plasma samples This assay uses a multiplex format to measure antibodies specific for the SARS-CoV-2 spike and nucleocapsid proteins The kit includes a plate coated with antigens detection antibodies calibrators controls diluent and wash buffer Results are obtained in under 3 hours using an MSD instrument This assay allows for high-throughput quantitative measurement of SARS-CoV-2 IgG antibodies
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The SARS-CoV-2 Panel 2 (ACE2) is a multiplex immunoassay panel from Meso Scale Diagnostics that detects antibodies to the SARS-CoV-2 spike and nucleocapsid proteins as well as the ACE2 receptor It uses electrochemiluminescence detection technology and provides quantitative results from human serum plasma or whole blood samples The panel includes reagents for 96 tests and can help evaluate immune responses in COVID-19 vaccine studies and natural infection It has high sensitivity and specificity and has received Emergency Use Authorization from the FDA
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The Mesoscale K15436U-4 is a 4-channel 16-bit 250 kS/s simultaneous sampling data acquisition module It has 4 analog voltage input channels with programmable gain amplifiers anti-aliasing filters and 16-bit ADCs The input voltage range is 10 V with software-selectable gains of 1 2 4 8 It has a USB interface and is compatible with Windows Linux and Mac operating systems The module is bus-powered and compact in size Key features include 250 kS/s sampling rate 16-bit resolution 4 analog input channels programmable gains anti-aliasing filters USB interface and cross-platform software support
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The V-PLEX Plus Metabolic Panel 1 Rat Kit from Meso Scale Discovery is a multiplex immunoassay kit that allows simultaneous measurement of 10 metabolic biomarkers in rat serum plasma and tissue culture media The kit includes a 96-well plate pre-coated with capture antibodies for insulin leptin amylin GLP-1 PYY ghrelin GIP C-peptide glucagon and resistin It utilizes electrochemiluminescence detection and provides high sensitivity broad dynamic range and requires low sample volume This kit allows efficient metabolic profiling and is suitable for studying diabetes obesity and metabolic disorders in rat models
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 1 Mouse IgG Kit is an electrochemiluminescence immunoassay that detects IgG antibodies to SARS-CoV-2 in mouse serum and plasma samples This assay uses the S1 and receptor binding domain (RBD) antigens to detect IgG antibodies that develop in response to SARS-CoV-2 infection or vaccination The V-PLEX technology allows for high sensitivity and specificity This kit includes a 96-well plate coated with antigens detection antibody read buffer calibrators controls 10X diluent and plate seals The assay procedure takes approximately 3 hours to complete
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The Meso Scale Discovery V-PLEX Metabolic Panel 1 Mouse Kit is designed to simultaneously quantify insulin leptin resistin and PAI-1 from mouse samples This 4-plex kit includes a 96-well plate coated with capture antibodies detection antibodies calibrators controls 10X diluent read buffer wash buffer and plate seals The electrochemiluminescent immunoassay allows sensitive detection of the analytes from as little as 25 L of sample This kit provides a streamlined workflow for measuring metabolic biomarkers from mouse serum plasma and culture supernatants With high sensitivity broad dynamic range and intra-/inter-assay precision this kit enables robust metabolic profiling
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The Meso Scale Diagnostics COVID-19 Coronavirus Panel 2 IgG is an in vitro diagnostic test kit that detects IgG antibodies to SARS-CoV-2 in human serum and plasma It uses electrochemiluminescence technology on Meso Scale Diagnostics proprietary MULTI-ARRAY platform The test kit includes a 96-well plate coated with SARS-CoV-2 antigens detection antibodies calibrators and controls It has 99 6% PPA and 99 6% NPA versus PCR and takes under 3 hours to run The test is CE marked and available for in vitro diagnostic use in countries recognizing the CE mark
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An a-AR antagonist inhibits norepinephrine-induced contractions in rat vas deferens guinea pig spleen and rat aorta regions that express high levels of a1A-AR a1B-AR and a1D-ARs respectively (pA2s 7 93 7 13 and 8 26 respectively) inhibits histamine- angiotensin II- pentagastrin- carbachol and serotonin-induced contractions in guinea pig ileum in a dose-dependent manner reverses pupil dilation induced by the combination of phenylephrine and tropicamide in rabbits
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